Patents by Inventor Osamu Nakaguti
Osamu Nakaguti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4940709Abstract: Diseases caused by platelet activating factor are prevented and treated by administration to a subject of a therapeutically effective amount of a piperazine compound of the formula: ##STR1## wherein R.sup.1 to R.sup.4 are as defined in the specification.Type: GrantFiled: November 20, 1987Date of Patent: July 10, 1990Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Norihiko Shimazaki, Keiji Hemmi, Osamu Nakaguti, Yoshio Miyazaki, Masashi Hashimoto
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Patent number: 4806538Abstract: The invention relates to a PAF-antagonist pharmaceutical composition comprising a compound of the formula: ##STR1## wherein R.sup.1 is pyridyl(lower)alkyl or thiazolyl(lower)alkyl,R.sup.2 is N-lower alkylindolyl(lower)alkyl which may have lower alkyl or halogen on the indole ring, andR.sup.3 and R.sup.4 are each hydrogen or lower alkyl; or pharmaceutically acceptable salt thereof.Type: GrantFiled: March 30, 1987Date of Patent: February 21, 1989Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Norihiko Shimazaki, Keiji Hemmi, Osamu Nakaguti, Yoshio Miyazaki, Masashi Hashimoto
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Patent number: 4694004Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is hydrogen,R.sup.2 is hydrogen, lower alkyl, ar(lower)alkyl, lower alkenyl or aryl,R.sup.3 is lower alkyl, ar(lower)alkyl, lower alkenyl or aryl, orR.sup.2 and R.sup.3 are taken together to form (C.sub.2 -C.sub.6)-alkylidene group optionally substituted with aryl or taken together with the attached nitrogen atom to form a saturated or unsaturated, 5- or 6-membered heterocyclic group optionally substituted with aryl or lower alkyl; orR.sup.1 and R.sup.2 are taken together with the attached nitrogen atoms to form a saturated or unsaturated, 5- or 6-membered heterocyclic group or 1,2-diazaspiroalkane-1,2-diyl group,R.sup.3 is hydrogen, lower alkyl, ar(lower)alkyl, lower alkenyl or aryl;R.sup.4 is lower alkyl optionally substituted with di(lower)alkylamino or a heterocyclic group, or a heterocyclic group optionally having suitable substituent(s),R.sup.Type: GrantFiled: June 19, 1985Date of Patent: September 15, 1987Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Osamu Nakaguti, Norihiko Shimazaki, Yoshio Kawai, Masashi Hashimoto, Michie Nakatuka
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Patent number: 4576753Abstract: This invention relates to new 2-azetidinone compounds, which have antimicrobial activities, and to processes for the preparation thereof, and more particularly, this invention provides new 2-azetidinone compounds, especially ones having various substituted carboxyalkyl radicals at the first position and having various groups at the fourth position of the azetidinone nucleus, which have antimicrobial activities against various pathogenic microorganisms and are useful as antibiotics in treatment for microbial infections in mammals including human beings and animals.Type: GrantFiled: July 9, 1984Date of Patent: March 18, 1986Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Masashi Hashimoto, Osamu Nakaguti
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Patent number: 4472309Abstract: This invention relates to new 2-azetidinone compounds, which have antimicrobial activities, and to processes for the preparation thereof, and more particularly, this invention provides new 2-azetidinone compounds, especially ones having various substituted carboxyalkyl radicals at the first position and having various group at the fourth position of the azetidinone nucleus, which have antimicrobial activity against various pathogenic microorganisms and are useful as antibiotics in treatment for microbial infections in mammals including human beings and animals.Type: GrantFiled: August 25, 1981Date of Patent: September 18, 1984Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku, Yoshiharu Nakai, Hidekazu Takeno
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Patent number: 4472300Abstract: New antimicrobial azetidinone derivatives and their salt of the formula: ##STR1## wherein R.sub.1 amino or acylamino, and A is selected from a variety of groups.Type: GrantFiled: March 13, 1980Date of Patent: September 18, 1984Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Yoshihisa Saito, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku, Youichi Shiokawa, Takao Takaya, Tadaaki Komori, Tsutomu Teraji, Keiji Hemmi, Hisashi Takasugi
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Patent number: 4435321Abstract: A process for producing a 2-cephem or 3-cephem derivative compound of the formula: ##STR1## wherein R.sub.1 represents a substituted or unsubstituted amino radical and R.sub.4 represents hydrogen or a radical selected from the group consisting of carboxy, protected carboxy, ester, acid amide, acid anhydride, acid halide, acid azide and carboxy salt, and the dotted line indicates the alternate bond structure providing 3-cephem or 2-cephem, which comprises:reacting a halogenated derivative selected from the group consisting of a halogenated penam derivative having the formula: ##STR2## a halogenated cephem derivative of the formula: ##STR3## wherein X represents a halogen atom, R.sub.3 represents a radical selected from the group consisting of carboxy, protected carboxy, ester, acid amide, acid anhydride, acid halide, acid azide and carboxy salt, and R.sub.1 is as defined above, or mixtures thereof with a dehydrohalogenoic acid reagent.Type: GrantFiled: December 1, 1980Date of Patent: March 6, 1984Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Yoshihisa Saito, Tsutomu Teraji, Osamu Nakaguti, Teruo Oku
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Patent number: 4410458Abstract: This invention relates to a process for preparing an oxidized penam derivative of the formula: ##STR1## wherein R.sub.1 represents an amino or protected amino radical, andR.sub.3 represents a radical selected from the group consisting of carboxy, protected carboxy, ester, acid amide, acid anhydride, acid halide, acid azide and carboxy salt, wherein a penam derivative of the formula: ##STR2## is oxidized with an oxidizing agent selected from the group consisting of hydrogen peroxide, peracids, hydroperacids, and salts thereof, the improvement which comprises conducting said oxidation in the presence of a catalytic amount of a Group Vb or VIb of the Periodic Table metal compound.Type: GrantFiled: December 7, 1981Date of Patent: October 18, 1983Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Suita Saito, Tsutomu Teraji, Osamu Nakaguti, Teruo Oko
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Patent number: 4308380Abstract: A compound of the formula ##STR1## wherein R.sup.1 is amino or substituted amino, R.sup.2 is carboxy or protected carboxy, R.sup.3 is lower alkyl and X is --S-- or ##STR2## or a pharmaceutically acceptable salt thereof is effective against various microorganisms.Type: GrantFiled: June 15, 1978Date of Patent: December 29, 1981Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Tsutomu Teraji, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku
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Patent number: 4304718Abstract: This invention relates to new 2-azetidinone compounds, which have antimicrobial activities, and to processes for the preparation thereof, and more particularly, this invention provides new 2-azetidinone compounds, especially ones having various substituted carboxyalkyl radicals at the first position and having various groups at the fourth position of the azetidinone nucleus, which have antimicrobial activities against various pathogenic microorganisms and are useful as antibiotics in treatment for microbial infections in mammal including human being and animals.Type: GrantFiled: August 30, 1979Date of Patent: December 8, 1981Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku, Yoshiharu Nakai, Hidekazu Takeno
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Patent number: 4267340Abstract: An oxoazetidine derivative compound of the formula: ##STR1## wherein R.sub.1 represents a substituted or unsubstituted amino radical and R.sub.3 represents a radical selected from the group consisting of carboxy, protected carboxy, ester, acid amide, acid anhydride, acid halide, acid azide and carboxy salt, and --SR.sub.2 is a residue of a thiophilic sulphur nucleophile.Type: GrantFiled: November 16, 1977Date of Patent: May 12, 1981Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Yoshihisa Saito, Tsutomu Teraji, Osamu Nakaguti, Teruo Oku, Hitoshi Nakamura, Masashi Hashimoto
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Patent number: 4264498Abstract: A process for preparing an azetidinone of the formula: ##STR1## which comprises reacting a C-unsubstituted methyleneamine of the formula: ##STR2## with R.sup.2 --CH.sub.2 COOH, its acid halide or anhydride, in the presence of boron trihalide and an organic base, wherein R.sup.1 is an organic residue bearing a carboxy group or its derivative and R.sup.2 is azido, substituted amino, halogen, acyloxy, alkoxy, aryloxy or aralkoxy.Type: GrantFiled: February 21, 1979Date of Patent: April 28, 1981Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku, Yoshiharu Nakai, Hidekazu Takeno
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Patent number: 4237305Abstract: Substituted phenylacetic acid compounds represented by the following general formula and preparation thereof: ##STR1## wherein R.sup.1 is hydrogen or protected carboxy,R.sup.2 is hydrogen, or protected amino, provided that when R.sup.1 is hydrogen, then R.sup.2 is protected amino, and when R.sup.2 is hydrogen, then R.sup.1 is protected carboxy,R.sup.3 is oxo, hydroxyimino or protected hydroxyimino,R.sup.4 is hydrogen or halogen, andm is an integer of 1 to 3.Type: GrantFiled: March 30, 1977Date of Patent: December 2, 1980Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku, Hidekazu Takeno
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Patent number: 4218374Abstract: A compound of the general formula: ##STR1## wherein R.sup.1 is amino or a conventional, pharmaceutically acceptable acylamino, R.sup.2 is carboxy or a conventionally protected carboxy, X is --S-- or ##STR2## R.sup.3 is lower alkyl and Y" is a residue of a strong nucleophile selected from the group consisting of azido, thiocyanato, lower alkyanoylthio and piperidinothiocarbonylthio.Type: GrantFiled: April 23, 1979Date of Patent: August 19, 1980Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takashi Kamiya, Tsutomu Teraji, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku
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Patent number: 4207234Abstract: New antimicrobial azetidinone derivatives and their salt of the formula: ##STR1## wherein R.sub.1 is amino or acylamino, and A is selected from a variety of groups.Type: GrantFiled: December 7, 1977Date of Patent: June 10, 1980Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Yoshihisa Saito, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku, Youichi Shiokawa, Takao Takaya, Tadaaki Komori, Tsutomu Teraji, Keiji Hemmi, Hisashi Takasugi
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Patent number: 4203897Abstract: A compound of the general formula: ##STR1## wherein R.sup.1 is amino or a conventional, pharmaceutically acceptable acylamino, R.sup.2 is carboxy or a conventionally protected carboxy, X is --S-- or ##STR2## R.sup.3 is lower alkyl and Y" is a residue of a strong nucleophile selected from the group consisting of azido, thiocyanato, lower alkyanoylthio and piperidinothiocarbonylthio.Type: GrantFiled: April 23, 1979Date of Patent: May 20, 1980Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takashi Kamiya, Tsutomu Teraji, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku
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Patent number: 4191762Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is (C.sub.1 to C.sub.6) alkyl,R.sup.2 is carboxy or a protected carboxy group,R.sup.3 is amino or a protected amino group, andA is carbonyl or hydroxy (C.sub.1 to C.sub.6) alkylene, andpharmaceutically acceptable salt thereof, which is active against pathogenic bacteria, and methods for preparing the same.Type: GrantFiled: June 21, 1977Date of Patent: March 4, 1980Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Tsutomu Teraji, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku
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Patent number: 4181800Abstract: This invention relates to new 2-azetidinone compounds, which have antimicrobial activities, and to processes for the preparation thereof, and more particularly, this invention provides new 2-azetidinone compounds, especially ones having various substituted carboxyalkyl radicals at the first position and having various groups at the fourth position of the azetidinone nucleus, which have antimicrobial activities against various pathogenic microorganisms and are useful as antibiotics in treatment for microbial infections in mammal including human being and animals.Type: GrantFiled: October 6, 1976Date of Patent: January 1, 1980Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku, Yoshiharu Nakai, Hidekazu Takeno
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Patent number: 4164497Abstract: A compound of the general formula: ##STR1## wherein R.sup.1 is amino or a conventional, pharmaceutically acceptable acylamino, R.sup.2 is carboxy or a conventionally protected carboxy, X is --S-- or ##STR2## R.sup.3 is lower alkyl and Y" is a residue of a strong nucleophile selected from the group consisting of azido, thiocyanato, lower alkyanoylthio and piperidinothiocarbonylthio.Type: GrantFiled: January 6, 1978Date of Patent: August 14, 1979Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Tsutomu Teraji, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku
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Patent number: 4113940Abstract: A compound of the formula ##STR1## wherein R.sup.1 is amino or substituted amino, R.sup.2 is carboxy or protected carboxy, R.sup.3 is lower alkyl and X is --S-- or ##STR2## or a pharmaceutically acceptable salt thereof is effective against various microorganisms.Type: GrantFiled: December 15, 1975Date of Patent: September 12, 1978Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Tsutomu Teraji, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku