Patents by Inventor Osamu Nishimura

Osamu Nishimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4980455
    Abstract: The present invention provides a novel polypeptide which shows higher IFN-.gamma. activity than intact IFN-.gamma. and a method of producing the same.The polypeptides not only possess a remarkable antiviral activity, antitumor activity, immunopotentiating activity but also is highly stable, therefore, it can be used advantageously as pharmaceuticals.
    Type: Grant
    Filed: December 22, 1987
    Date of Patent: December 25, 1990
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Masao Sakaguchi, Susumu Honda, Osamu Nishimura
  • Patent number: 4487726
    Abstract: A guanidino group in an amino acid or a peptide can be protected with a specific group, i.e. pentamethylbenzenesulfonyl, 2,4,6-trimethoxybenzenesulfonyl, 4-methoxy-2,3,5,6-tetramethylbenzenesulfonyl, 4-methoxy-2,6-dimethylbenzenesulfonyl or 4-methoxy-2,3,6-trimethylbenzenesulfonyl, and said group may easily be removed without affecting the amino acid or the peptide to be derived from the protected amino acid or peptide. Thus, the present invention is useful in the synthesis of peptides containing the guanidino group.
    Type: Grant
    Filed: September 21, 1982
    Date of Patent: December 11, 1984
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Masahiko Fujino, Osamu Nishimura
  • Patent number: 4368150
    Abstract: A guanidino group in an amino acid or a peptide can be protected with a specific group, i.e. pentamethylbenzensulfonyl, 2,4,6-trimethoxybenzenesulfonyl, 4-methoxy-2,3,5,6-tetramethylbenzenesulfonyl, 4-methoxy-2,6-dimethylbenzenesulfonyl or 4-methoxy-2,3,6-trimethylbenzenesulfonyl, and said group may easily be removed without affecting the amino acid or the peptide to be derived from the protected amino acid or peptide. Thus, the present invention is useful in the synthesis of peptides containing the guanidino group.
    Type: Grant
    Filed: February 11, 1981
    Date of Patent: January 11, 1983
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Masahiko Fujino, Osamu Nishimura
  • Patent number: 4229438
    Abstract: Novel nonapeptides of the formula:pGlu-X-Lys-Ser-Gln-Y-Z-Ser-Asn-OHwherein X is Ala or (D)-Ala; Y and Z are the same or different and each is the residue of a D-amino acid containing 3 to 9 carbon atoms, or Gly; and at least one of X, Y and Z is the residue of D-amino acid, have immunoregulator activity and are of value as medicines.
    Type: Grant
    Filed: May 7, 1979
    Date of Patent: October 21, 1980
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Masahiko Fujino, Osamu Nishimura, Muneo Takaoki
  • Patent number: 4111924
    Abstract: A novel method for removal of protective group(s) from an amino acid or peptide having thiol group(s) protected with p-methoxybenzyl, 1-adamantyl or t-butyl group by treating the protected amino acid or peptide with the mercuric salt of acetic acid or halogenoacetic acid, the removal being effected selectively and very smoothly in a good yield under extremely mild conditions without giving any undesirable influence upon other functional or protective group(s).
    Type: Grant
    Filed: June 13, 1977
    Date of Patent: September 5, 1978
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Masahiko Fujino, Osamu Nishimura, Chieko Kitada
  • Patent number: 4100152
    Abstract: A novel peptide of the formula: ##STR1## wherein A is hydrogen, alkyl, aralkyl, alkoxyalkyl, hydroxyalkyl or alkoxy; R is ##STR2## X is --S-- or --(CH.sub.2).sub.n -- where n is 1 or 2 has a weaker TRH releasing activity than TRH and a stronger anaesthesia-antagonistic activity, spontaneous movement-stimulant activity or dopamine-potentiating activity than TRH.
    Type: Grant
    Filed: March 16, 1977
    Date of Patent: July 11, 1978
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Masahiko Fujino, Osamu Nishimura, Yuji Nagawa, Naohisa Fukuda
  • Patent number: 3997516
    Abstract: A guanidino group in an amino acid or a peptide can be protected with a specific protective group, i.e. lower alkoxybenzenesulfonyl group or tri-lower alkylbenzenesulfonyl group, and the protective group may easily be removed without affecting the amino acid or the peptide to be derived from the protected amino acid or peptide. Thus, the method is useful in the related chemical industries, especially in the peptide synthesis.
    Type: Grant
    Filed: June 27, 1975
    Date of Patent: December 14, 1976
    Assignee: Takeda Chemical Industries, Ltd.
    Inventor: Osamu Nishimura
  • Patent number: 3959245
    Abstract: A novel dipeptide, L-aspartyl-aminomalonic acid methyl 2-methylcyclohexyl diester and its physiologically acceptable salts which are useful as a sweetener, and production thereof and sweetening compositions containing the dipeptide or its salt.
    Type: Grant
    Filed: March 27, 1973
    Date of Patent: May 25, 1976
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Nobuo Nakajima, Hisashi Aoki, Masahiko Fujino, Osamu Nishimura, Mitsuhiro Wakimasu, Mitsuhiko Mano