Patents by Inventor Osamu Shiho

Osamu Shiho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Neurotrophin-3-deficient embryonic stem cells and mice and their use
    Patent number: 5625123
    Abstract: The present invention provides mouse embryonic stem cells and homozygous mutant mice carrying disruptions in the neurotrophin-3 (NT-3) gene generated by homologous recombination which results in the insertion of a reporter gene or a drug-resistance gene into an exon of the neurotrophin-3 gene. The mice harboring such homozygous mutations have a reduced number of sensory neurons compared with the number of sensory neurons present in a mouse lacking such mutations. These mice may be used to screen for substances that enhance the transcriptional activity of the NT-3 gene.
    Type: Grant
    Filed: June 29, 1994
    Date of Patent: April 29, 1997
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Osamu Shiho, Yoshihiko Kaisho, Hideaki Tojo