Abstract: A first longitudinal grip force FGG is calculated by differentiating a vehicle body speed by time. A driven wheel torque is calculated from an engine torque and a second longitudinal grip force FGT is calculated from the driven wheel torque. The first longitudinal grip force FGG and the second longitudinal grip force FGT are compared with each other, and the higher one of such grip force is selected as a longitudinal grip force TG. When the vehicle travels on a normal flat road, the first longitudinal grip force FGG obtained from the vehicle body speed is selected. But when the vehicle travels on an ascent road, on which the first longitudinal grip does not indicate an accurate value, the second longitudinal grip force FGT obtained from the engine torque is selected. With this arrangement, the longitudinal grip force is accurately estimated even if the vehicle travels on such an ascent road.

Abstract: The rotational speed difference between rotational speeds of front and rear road wheels of a motor vehicle is weighted by a first ratio, and the difference between the rotational speed difference between rotational speeds of front left and right road wheels and an average signal of reference steering angle or between the rotational speed difference between rotational speeds of rear left and right road wheels and the average signal of reference steering angle is weighted by a second ratio. A sum signal representative of the sum of the rotational speed difference weighted by the first ratio and the difference weighted by the second ratio is used to determine a pneumatic tire pressure reduction highly accurately even when running conditions of the motor vehicle change such as when the motor vehicle makes a turn.

Abstract: A method for determining the fully-closed state of a subsidiary throttle valve. If a stable state judging circuit judges that there is no outside influence exerted on the operational state of the engine (a state in which the vehicle is stopped and the engine is in an idling state) even if the subsidiary throttle valve is fully closed, a valve closing circuit closes the subsidiary throttle valve and a fully-closed state determination is carried out. If the opening degree of the subsidiary throttle valve or the engine revolution number is largely varied during the determination process of the fully-closed state determination circuit, a valve-closing inhibiting circuit inhibits the closing of the subsidiary throttle valve to discontinue the determination.

Abstract: In a traction control device in which an initial control torque of an engine is determined in accordance with an acceleration of the vehicle, when an excessive slipping of driven wheels is detected, a time taken for proceeding of the excessive slipping of the driven wheels from a large slip state to a small slip state is counted by a timer. If such time is smaller than a reference time and a gear ratio of the vehicle is of a first gear shift to provide a low vehicle speed, it is decided that the vehicle is traveling on an upward sloping road, and a lower limit value for defining the initial control torque of the engine determined in an initial control torque calculating means is corrected into an increased value in an initial torque correcting means. This prevents the initial control torque of the engine from being excessively reduced at the start of a traction control.

Abstract: Compounds having an activity to stimulate the carcinostatic effect of carcinostatic agents, which can be expressed by the following general formula (1): ##STR1## in which A is ##STR2## (in which R.sub.1, R.sub.2 and R.sub.3 are each independent and represent a hydrogen atom or a phenyl group) are made into fumarates so as to improve their oral absorbability and solubility in water without interfering with their effects.

Abstract: Therapeutic agents for degressive diseases in the central nervous system, which contain amide derivatives of dihydrocaffeic acid of the general formula (I) ##STR1## wherein, R.sub.1 and R.sub.2 and A are defined in the specification; the compounds exert a nerve growth factor inducing action and thus are effective for the prevention of the progression of degenerative diseases in the central nervous system and the therapeutic treatment thereof.

Abstract: Dihydrocaffeic acid derivatives are here disclosed which are applicable as medicines having excellent absorbency in the case of oral administration and good concentration retention in blood.The disclosed compounds have the function to induce the production and secretion of a nerve growth factor (NGF) in the brain tissue, and therefore they are effective as medicines for the progression inhibition and therapy of regressive disorders of the central nervous system.

Abstract: Dihydrocaffeic acid derivatives are here disclosed which are applicable as medicines having excellent absorbency in the case of oral administration and good concentration retention in blood.The disclosed compounds have the function to induce the production and secretion of a nerve growth factor (NGF) in the brain tissue, and therefore they are effective as medicines for the progression inhibition and therapy of regressive disorders of the central nervous system.

Abstract: DNAs, the salts thereof, the mixtures of DNA and RNA in which the DNA is mostly contained, and the mixtures of the salt of DNA and the salt of RNA in which the salt of DNA is mostly contained are used as active ingredients for pharmaceutical preparations for digestive ulcer, for example, DNA and RNA being obtained from BCG.

Abstract: Thermally-denatured DNA MD-011 having an antitumor activity was obtained by heating the substance separated from the disrupted cells of bacteria belonging to genus Mycobacterium.