Abstract: The invention relates to a goniometer that enables precise marking of the desired ocular axis in the phase immediately after surgery for the treatment of astigmatism. It essentially consists of two circular, transparent discs, one of which is at least axially stationary, in which the angles from 0° to 180° are marked, which are aligned with the angles from 0° to 180° of the patient's eye; and the other one of which is movable both angularly and axially, with a reference mark (9) and moving rigidly connected to a marking part (12), impregnated with die, which is responsible for marking the eye. Not only does the device make it possible to carry out said marking in a precise and comfortable manner, it also makes it possible to measure the angle of toric lenses already implanted.

Abstract: A method for improving reading proficiency in persons in need of improvement. The method includes the steps of providing a body of digital text on an electronic device; extracting a selected portion of digital text from the body of digital text; analyzing the selected portion by natural language processing to produce a phonetical font, the phonetical font including a representation of a letter that when heard or said voices a phoneme of the letter; rendering the analyzed selected portion into the phonetical font; and utilizing the phonetical font to increase reading proficiency.

Abstract: A method for improving reading proficiency in persons in need of improvement. The method includes the steps of providing a body of digital text on an electronic device; extracting a selected portion of digital text from the body of digital text; analyzing the selected portion by natural language processing to produce a phonetical font, the phonetical font including a representation of a letter that when heard or said voices a phoneme of the letter; rendering the analyzed selected portion into the phonetical font; and utilizing the phonetical font to increase reading proficiency.

Abstract: A method for improving reading proficiency in persons in need of improvement. The method includes the steps of providing a body of digital text on an electronic device; extracting a selected portion of digital text from the body of digital text; analyzing the selected portion by natural language processing to produce a phonetical font, the phonetical font including a representation of a letter that when heard or said voices a phoneme of the letter; rendering the analyzed selected portion into the phonetical font; and utilizing the phonetical font to increase reading proficiency.

Abstract: A method for predicting or prognosticating the response of individuals with multiple sclerosis to treatment with IFN?, kit or device, and uses.

Abstract: An optical film made from a light-permeable material includes a surface and an optical microstructure having a plurality of elevations. The elevations of the microstructure protrude from a reference plane, which is parallel to the surface. The elevations of the microstructure each have a flank section which adjoins the reference plane and forms a uniform angle with the reference plane. The uniform angle is in a range from about 33° to about 42° or in a range from about 35° to about 40°. The optical film according to the invention makes it possible to provide a light fixture with relatively strong glare suppression and at the same time to produce a preferred light distribution curve (LDC). In addition, it can be relatively flexibly moulded and cost-effectively produced.

Abstract: An optical layer made from a light-permeable material includes a surface and an optical microstructure having a plurality of elevations. The elevations of the microstructure protrude from a reference plane, which is parallel to the surface. The elevations of the microstructure each have a flank section which adjoins the reference plane and forms a uniform angle with the reference plane. The uniform angle is in a range from about 10° to about 26° or in a range from about 13° to about 23° or in a range from about 15° to about 20°. The optical layer according to the invention makes it possible for a light fixture to achieve a high light output rate (LOR) at the same time to produce a preferred light distribution curve (LDC).

Abstract: A method for improving reading proficiency in persons in need of improvement. The method includes the steps of providing a body of digital text on an electronic device; extracting a selected portion of digital text from the body of digital text; analyzing the selected portion by natural language processing to produce a phonetical font, the phonetical font including a representation of a letter that when heard or said voices a phoneme of the letter; rendering the analyzed selected portion into the phonetical font; and utilizing the phonetical font to increase reading proficiency.

Abstract: A composite packaging foil for a childproof and/or senior friendly packaging, including a first layer having a first outer surface and a first inner surface, wherein the first layer imparts tear-inhibiting properties to the packaging foil, a second layer having a second outer surface and a second inner surface, wherein the second outer surface of the second layer is sealable against a mating surface, an inner layer arranged between the first inner surface of the first layer and the second inner surface of the second layer. The packaging foil has at least one weakening zone in which the tear-inhibiting properties of the packaging foil are reduced by a plurality of perforations that are present in the first layer. The density of perforations in the weakening zone lies between 50 and 250, preferably between 50 and 150 and particularly preferred between 70 and 130 perforations per cm2.

Abstract: A white light source includes an array of light emitting elements arranged to a light guide. A light in-coupling array is arranged so that each light emitting element faces a light in-coupling element to incouple in the light guide a portion of the divergent light beams so that the in-coupled angle of at least a part of the light rays of the in-coupled light beam is higher than 45°. An array of light homogenizing elements is arranged so that each light homogenizing element faces a light incoupling element and so that the deflection angle of at least a fraction of the incident part of the in-coupled light beam incident on each of said homogenizing elements is higher than 45°. The white light source provides a uniform outcoupled white light beam.

Abstract: The invention relates to a recombinant protein and uses thereof in the diagnosis and treatment of multiple sclerosis. The invention also relates to the recombinant protein IFNAR2.3, antibodies, compositions comprising same, and uses thereof. Among the uses thereof, the invention especially relates to a method for the diagnosis of multiple sclerosis, and to the diagnosis kit. The invention further relates to the use of the protein IFNAR2.3 in the preparation of a medicament for the treatment of multiple sclerosis.

Abstract: An optical layer made from a light-permeable material includes a surface and an optical microstructure having a plurality of elevations. The elevations of the microstructure protrude from a reference plane, which is parallel to the surface. The elevations of the microstructure each have a flank section which adjoins the reference plane and forms a uniform angle with the reference plane. The uniform angle is in a range from about 10° to about 26° or in a range from about 13° to about 23° or in a range from about 15° to about 20°. The optical layer according to the invention makes it possible for a light fixture to achieve a high light output rate (LOR) at the same time to produce a preferred light distribution curve (LDC).

Abstract: An optical film made from a light-permeable material includes a surface and an optical microstructure having a plurality of elevations. The elevations of the microstructure protrude from a reference plane, which is parallel to the surface. The elevations of the microstructure each have a flank section which adjoins the reference plane and forms a uniform angle with the reference plane. The uniform angle is in a range from about 33° to about 42° or in a range from about 35° to about 40°. The optical film according to the invention makes it possible to provide a light fixture with relatively strong glare suppression and at the same time to produce a preferred light distribution curve (LDC). In addition, it can be relatively flexibly moulded and cost-effectively produced.

Abstract: A white light source includes an array of light emitting elements arranged to a light guide. A light in-coupling array is arranged so that each light emitting element faces a light in-coupling element to incouple in the light guide a portion of the divergent light beams so that the in-coupled angle of at least a part of the light rays of the in-coupled light beam is higher than 45°. An array of light homogenizing elements is arranged so that each light homogenizing element faces a light incoupling element and so that the deflection angle of at least a fraction of the incident part of the in-coupled light beam incident on each of said homogenizing elements is higher than 45°. The white light source provides a uniform outcoupled white light beam.

Abstract: An organic light emitting device comprises a light emitting layer comprising a light emitting polymer; and an electron transporting layer on the light emitting layer and comprising an electron transporting material and an n-donor material. The electron transporting layer comprises at least 20 percent by weight of the n-donor material. By using an electron transporting layer comprising at least 20 percent by weight of the n-donor material it is possible to realise devices with an electron transporting layer having a thickness of less than 20 nm.

Abstract: Provided are chemical entities selected from compounds of formula (I), wherein R1, R2 and m have meanings given in the description, and pharmaceutically acceptable salts, solvates and stereoisomers thereof, which are inhibitors of ATR and are potentially useful in the treatment of cancer. Further provided are pharmaceutical compositions of the chemical entities, combination products containing the chemical entities, the use of the compositions as therapeutic agents, and methods of treatment using these compositions.

Abstract: Provided are chemical entities selected from compounds of formula (I), wherein R1, R2 and m have meanings given in the description, and pharmaceutically acceptable salts, solvates and stereoisomers thereof, which are inhibitors of ATR and are potentially useful in the treatment of cancer. Further provided are pharmaceutical compositions of the chemical entities, combination products containing the chemical entities, the use of the compositions as therapeutic agents, and methods of treatment using these compositions.

Abstract: The invention relates to a recombinant protein and uses thereof in the diagnosis and treatment of multiple sclerosis. The invention also relates to the recombinant protein IFNAR2.3, antibodies, compositions comprising same, and uses thereof. Among the uses thereof, the invention especially relates to a method for the diagnosis of multiple sclerosis, and to the diagnosis kit. The invention further relates to the use of the protein IFNAR2.3 in the preparation of a medicament for the treatment of multiple sclerosis.

Abstract: An organic electroluminescent device comprises an anode; a cathode; a first electroluminescent layer between the anode and the cathode comprising an electron transporting material; and a second electroluminescent layer between the first electroluminescent layer and the anode. The second electroluminescent layer comprises a hole transporting material and an electroluminescent electron trapping material. The first electroluminescent layer may comprises a polymer having an electron transporting material and an electroluminescent material, and may include an optionally electroluminescent hole-transporting material. The electron transporting material and one or both of the hole transporting material of the first electroluminescent layer and the electroluminescent material of the first electroluminescent layer are part of the same molecule or polymer. Preferably, the electron transporting material comprises a plurality of adjacent arylene repeat units.

Abstract: An organic light-emitting device comprises an anode; a cathode; a charge transporting layer comprising a charge-transporting material doped with a light-emitting dopant between the anode and the cathode; and a light-emitting layer between the anode and the cathode. The x-coordinate value and/or the y-coordinate value of CIE(x,y) coordinates of light emitted from the device is no more than 0.1, and preferably no more than 0.05, from the respective x- or y-coordinate value of a control device in which the charge transporting layer is not doped with a light-emitting dopant. The light emitting layer and charge transport material preferably comprise polymers including aryl or heteroaryl repeat units.