Abstract: A new intermediate is useful in the synthesis of elagolix. A process for obtaining the intermediate includes reacting a precursor with iodine monochloride in the presence of an organic solvent. A process for preparing elagolix makes use of the intermediate. The intermediate can be 3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6-trifluoromethylbenzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, such as a hydrochloride.

Abstract: Described herein are examples of medical devices which include a rigid dome and a torus channel. The rigid dome has a hemispherical geometry with an open side to surround a surgical site. The rigid dome has a concave geometry to bound the surgical site, a dome vacuum port to provide fluid communication for a vacuum source to reduce a pressure within the rigid dome, an aperture to provide access to the surgical site, and a septum to form a penetrable barrier at the aperture to access the surgical site. The torus channel is coupled to the rigid dome to extend along a periphery of the rigid dome. The torus channel has a partial toroidal geometry forming a ring around the rigid dome. The torus channel includes a channel vacuum port to provide fluid communication for a vacuum source to reduce a pressure within an interior of the torus channel.

Abstract: Medical devices for use in the creation of a temporary pneumoperitoneum include a rigid dome, a sealing element, a retaining band, a septum, and a vacuum port. The rigid dome includes first and second dome sections. The first dome section engages with the second dome section to form the rigid dome. The retaining band applies a force to secure the first dome section relative to the second dome section. The sealing element seals the first and second dome sections. The septum engages at an aperture between the first and second dome sections. The vacuum port connects a vacuum source to the rigid dome to reduce a pressure on an interior of the rigid dome.

Abstract: A new intermediate is useful in the synthesis of elagolix. A process for obtaining the intermediate includes reacting a precursor with iodine monochloride in the presence of an organic solvent. A process for preparing elagolix makes use of the intermediate. The intermediate can be 3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6-trifluoromethylbenzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, such as a hydrochloride.

Abstract: Medical devices include a rigid dome, a viewing window, a vacuum port, a vacuum pressure regulator, an aperture, and a septum. The rigid dome is hemispherical and includes a first dome stage, a second dome stage distal on the first dome stage, and a transition between the first dome stage and the second dome stage. The viewing window is acoustically and\or optically transparent to allow for inspection of the surgical site. The vacuum port allows for a reduction of a pressure on the interior of the rigid dome. The vacuum pressure regulator regulates the pressure on the interior of the rigid dome. The aperture provides access to the interior of the rigid dome and the surgical site. The septum engages with the second dome stage to allow for insertion of a surgical instrument with resistance to loss of the pressure on the interior of the rigid dome.

Abstract: A cook top with at least two heating elements includes a power electronics arrangement connected to a domestic single phase AC supply. The power electronics arrangement includes several power supply units, which each supply heating currents to one or more heating elements, and a switch arrangement with several electromechanical relays for connecting/disconnecting the power supply units to/from the heating elements. Output poles of at least two electromechanical relays associated with different power supply units are connected in parallel, wherein the parallel connection is permanently connected to at least one of the heating elements. This arrangement reduces the number of switching processes required for alternating use of a power supply device with several heating elements, and simplifies compliance with electromagnetic compatibility standards.

Abstract: A cooktop apparatus, in particular an induction cooktop apparatus, includes a switching unit configured to interrupt and establish current flow from a current supply, a first switching element receiving the current flow during an operating process, a control apparatus, which controls the switching unit during the operating process such that the switching unit interrupts the current supply during a first time interval which has a duration of less than of half a period of the power supply voltage. The control apparatus causes the current supply to be connected during the operating process immediately before and immediately after the first time interval. The first switching element begins switching and ends switching during the first time interval.

Abstract: A heating apparatus, in particular a hob heating apparatus, with at least one heating connection for at least one heating element and at least one frequency unit. In order to provide a heating apparatus of the generic type with relatively high operational reliability, it is proposed that the heating apparatus comprises a protective unit, which is provided for determining the existence of a conducting path between the frequency unit and the at least one heating connection.

Abstract: The present invention relates to a cartridge-in-chamber detection system for firearms which is independent in situations where the user comes into contact with metal parts of the weapon or situations where said contact does not exist, to provide a reliable indication of the presence or absence of the cartridge in the chamber, where the system comprises means to, through a supply voltage, determine the variation of the electrical capacity between two possible states of the system, when there is no cartridge in the chamber and when there is a cartridge in the chamber, making use of at least one electrode, regardless of the grip performed by the user.

Abstract: The method for making a reinforced balloon for a balloon catheter involves blending a polymer with a nano composite to form a composite matrix, extruding a parison from the composite matrix, blow molding the parison into a balloon and orienting the nano composite generally axially with respect to the balloon. The balloon formed has a high strength for resisting bursting. The nano composite may be carbon nanotubes, nano-ceramic fibers or a nano clay.

Abstract: The method for making a reinforced balloon for a balloon catheter involves blending a polymer with a nano composite to form a composite matrix, extruding a parison from the composite matrix, blow molding the parison into a balloon and orienting the nano composite generally axially with respect to the balloon. The balloon formed has a high strength for resisting bursting. The nano composite may be carbon nanotubes, nano-ceramic fibers or a nano clay.

Abstract: The intravascular catheter has a polymeric inner tube, a reinforcing inner jacket which is spirally wound over the inner tube and which becomes progressively softer from a proximal end to a distal end, and a polymeric outer sheath extruded over the inner jacket. The reinforcing jacket includes helical coiled wires wound over the inner tube in order to provide improved multi-axial mechanical properties.

Abstract: The intravascular catheter has two segments; a proximal segment with high stiffness and a distal segment with lower stiffness. The catheter can also have an intermediate segment of lower stiffness than the proximal segment and higher stiffness than the distal segment. The catheter comprises a polymeric inner tube, a reinforcing inner jacket which is spirally wound over the inner tube and which becomes progressively softer from a proximal end to a distal end, and a polymeric outer sheath extruded over the inner jacket according to the teachings of U.S. Pat. No. 5,445,624. The reinforcing jacket comprises helical coiled wires or fibers of various materials and layers wound over the inner tube in order to provide improved multi-axial mechanical properties, such as torque, compression, tension and anti-kinking characteristics.

Abstract: The method for making a reinforced balloon for a balloon catheter involves blending a polymer with a nano composite to form a composite matrix, extruding a parison from the composite matrix, blow molding the parison into a balloon and orienting the nano composite generally axially with respect to the balloon. The balloon formed has a high strength for resisting bursting. The nano composite may be carbon nanotubes, nano-ceramic fibers or a nano clay.

Abstract: The method for making a reinforced balloon for a balloon catheter involves blending a polymer with a nano composite to form a composite matrix, extruding a parison from the composite matrix, blow molding the parison into a balloon and orienting the nano composite generally axially with respect to the balloon. The balloon formed has a high strength for resisting bursting. The nano composite may be carbon nanotubes, nano-ceramic fibers or a nano clay.

Abstract: A heating apparatus, in particular a hob heating apparatus, with at least one heating connection for at least one heating element and at least one frequency unit. In order to provide a heating apparatus of the generic type with relatively high operational reliability, it is proposed that the heating apparatus comprises a protective unit, which is provided for determining the existence of a conducting path between the frequency unit and the at least one heating connection.

Abstract: A cooktop apparatus, in particular an induction cooktop apparatus, includes a switching unit configured to interrupt and establish current flow from a current supply, a first switching element receiving the current flow during an operating process, a control apparatus, which controls the switching unit during the operating process such that the switching unit interrupts the current supply during a first time interval which has a duration of less than of half a period of the power supply voltage. The control apparatus causes the current supply to be connected during the operating process immediately before and immediately after the first time interval. The first switching element begins switching and ends switching during the first time interval.

Abstract: The intravascular catheter has two segments; a proximal segment with high stiffness and a distal segment with lower stiffness. The catheter can also have an intermediate segment of lower stiffness than the proximal segment and higher stiffness than the distal segment. The catheter comprises a polymeric inner tube, a reinforcing inner jacket which is spirally wound over the inner tube and which becomes progressively softer from a proximal end to a distal end, and a polymeric outer sheath extruded over the inner jacket according to the teachings of U.S. Pat. No. 5,445,624. The reinforcing jacket comprises helical coiled wires or fibers of various materials and layers wound over the inner tube in order to provide improved multi-axial mechanical properties, such as torque, compression, tension and anti-kinking characteristics.

Abstract: A cook top with at least two heating elements includes a power electronics arrangement connected to a domestic single phase AC supply. The power electronics arrangement includes several power supply units, which each supply heating currents to one or more heating elements, and a switch arrangement with several electromechanical relays for connecting/disconnecting the power supply units to/from the heating elements. Output poles of at least two electromechanical relays associated with different power supply units are connected in parallel, wherein the parallel connection is permanently connected to at least one of the heating elements. This arrangement reduces the number of switching processes required for alternating use of a power supply device with several heating elements, and simplifies compliance with electromagnetic compatibility standards.