Patents by Inventor Oscar M. PEREZ-LEAL

Oscar M. PEREZ-LEAL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA plasmids for the fast generation of homologous recombination vectors for cell line development
    Patent number: 10883120
    Abstract: The present invention provides homologous recombination vectors to insert transgenic DNA in cells. These vectors shorten the production time and allow for easy generation of genetically modified cells. The invention allows the user to test multiple tags and to generate homozygous modified cell line using the homologous recombination vector. The invention can be used to generate knockout cells, to generate cell lines with knockin genes, to generate cell lines for drug screening against any target, to create transgenic animals, or in gene therapy.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: January 5, 2021
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventor: Oscar M. Perez-Leal
  • DNA plasmids for the Fast Generation of Homologous Recombination Vectors For Cell Line Development
    Publication number: 20200002729
    Abstract: The present invention provides homologous recombination vectors to insert transgenic DNA in cells. These vectors shorten the production time and allow for easy generation of genetically modified cells. The invention allows the user to test multiple tags and to generate homozygous modified cell line using the homologous recombination vector. The invention can be used to generate knockout cells, to generate cell lines with knockin genes, to generate cell lines for drug screening against any target, to create transgenic animals, or in gene therapy.
    Type: Application
    Filed: September 12, 2019
    Publication date: January 2, 2020
    Inventor: Oscar M. Perez-Leal
  • DNA Plasmids for the Fast Generation of Homologous Recombination Vectors for Cell Line Development
    Publication number: 20190284582
    Abstract: The present invention provides homologous recombination vectors to insert transgenic DNA in cells. These vectors shorten the production time and allow for easy generation of genetically modified cells. The invention allows the user to test multiple tags and to generate homozygous modified cell line using the homologous recombination vector. The invention can be used to generate knockout cells, to generate cell lines with knockin genes, to generate cell lines for drug screening against any target, to create transgenic animals, or in gene therapy.
    Type: Application
    Filed: November 3, 2017
    Publication date: September 19, 2019
    Inventor: Oscar M. Perez-Leal
  • Nuclear factor-erythroid 2 related factor 2 (NRF2) biosensors and modulators of NRF2
    Patent number: 10054583
    Abstract: Compositions include nucleic acid sequences encoding the C-terminal fragment of fragment (Seg3) of Nuclear factor-erythroid 2 related factor 2 (Nrf2). These compositions provide a target for identification of novel therapeutics having the ability to modulate the translation of Nrf2. Methods of treating subjects are also provided.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: August 21, 2018
    Assignee: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Oscar M. Perez-Leal, Salim Merali, Carlos A. Barrero
  • NUCLEAR FACTOR-ERYTHROID 2 RELATED FACTOR 2 (NRF2) BIOSENSORS AND MODULATORS OF NRF2
    Publication number: 20160146785
    Abstract: Compositions include nucleic acid sequences encoding the C-terminal fragment of fragment (Seg3) of Nuclear factor-erythroid 2 related factor 2 (Nrf2). These compositions provide a target for identification of novel therapeutics having the ability to modulate the translation of Nrf2. Methods of treating subjects are also provided.
    Type: Application
    Filed: October 9, 2013
    Publication date: May 26, 2016
    Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Oscar M. PEREZ-LEAL, Salim MERALI, Carlos A. BARRERO