Abstract: The present invention belongs to the field of genetic therapy. In particular, the invention refers to EphA2 specific RNA-based constructs, which are useful for the treatment, prevention and diagnosis of EphA2 expressing cancers.

Abstract: Optical assemblies for use in virtual and augmented reality environments are described. The optical assemblies may include lenses, filter stacks, cameras, and image projecting devices. For example, the optical assemblies may include at least one lens, a first filter stack between the at least one lens and an image projecting device, a second filter stack between the first filter stack and the image projecting device, and a camera configured to capture images of an infrared reflection of light through the at least one lens.

Abstract: An apparatus (1) for the packaging of products in pre-made containers (100, 101) that comprises a receiving station (2) for containers and at least two workstations (3, 4) each on one side of that receiving station; the apparatus comprising container transfer means (5) that are equipped with at least two holding groups (6, 7) prepared to hold containers in a suspended way and that can move between at least two positions, one that coincides with the container receiving station (2) and the other that coincides with one of the two workstations (3 or 4), such that the transfer means are able to serve the pre-made containers received in that receiving station to one side and to the other side of the receiving station, and to corresponding workstations, in an alternating way.

Abstract: A method and system for detecting software is provided. The method includes executing determination software for detecting a decision associated with an individual of a plurality of individuals. A selection for a specified user type associated with the individual is received and a push notification is transmitted. In response, specified software loaded within active devices is activated and the active device is registered with a valid hardware node within a blockchain instance. The valid node is associated with a group of digital tokens and an associated group of blockchain addresses and modified digital tokens are transmitted to the valid node. A weighting value is assigned to the modified digital token and the modified digital token is analyzed with respect to an associated weighting value. In response, the determination software is modified.

Abstract: A near-eye display system includes a display panel to emit display light representative of a display image and a lens assembly disposed along an optical axis. The lens assembly includes a first phase mask plate having a first major surface facing the display and a second major surface opposite the first major surface, the second major surface implementing a first freeform Fresnel lens structure, and further includes a second phase mask plate adjacent and parallel to the first phase mask plate and having a third major surface facing the second major surface and an opposing fourth majors surface, the third major surface implementing a second freeform Fresnel lens structure. A pose of at least one of the first and second phase mask plates relative to the other is configured to be adjusted so as to adjust an optical power of the lens assembly.

Abstract: A system includes an electronic display for emitting light toward an eye-ward side of the system. A beam splitter receives emitted light from the display. The beam splitter includes a polarization beam splitting (PBS) film and a mirror coating to generate two orthogonal polarization states with different optical paths thereby creating a first focal plane and a second focal plane at the eye-ward side of the system. At least one liquid crystal switch is positioned to receive light from the display in a light path between the display and the eye-ward side of the system.

Abstract: A method and system for detecting software is provided. The method includes executing determination software for detecting a decision associated with an individual of a plurality of individuals. A selection for a specified user type associated with the individual is received and a push notification is transmitted. In response, specified software loaded within active devices is activated and the active device is registered with a valid hardware node within a blockchain instance. The valid node is associated with a group of digital tokens and an associated group of blockchain addresses and modified digital tokens are transmitted to the valid node. A weighting value is assigned to the modified digital token and the modified digital token is analyzed with respect to an associated weighting value. In response, the determination software is modified.

Abstract: A near-eye display system includes a polarization waveguide having an in-coupling interface disposed proximate to a first end and an out-coupling interface disposed proximate to an opposite second end. The polarization waveguide is configured to convey light incident at the in-coupling interface to the out-coupling interface by inducing multiple changes in a polarization state of the light as the light traverses the polarization waveguide. At least a subset of the changes in polarization state induce the light to reflect within the polarization waveguide without relying on total internal reflection (TIR).

Abstract: An example of a printing carriage system is disclosed. The example disclosed herein comprises a plurality of printheads, and a positioning mechanism. The plurality of printheads comprises a moveable printhead that is moveable with respect to other printheads from the plurality of printheads. The positioning mechanism is to move the moveable printhead from a first printhead position to a second printhead position.

Abstract: A near-eye display system includes an optical system facing a display panel. The optical system includes an input filter, and output filter, and a variable-power catadioptric lens assembly disposed between the input and output filters. The input and output filters are configured, along with the catadioptric lens assembly to fold a path of display light from the display panel to a user's eye. The catadioptric lens assembly includes two or more lens elements disposed along an optical axis, each lens element having at least one surface with a freeform curvature. One of the lens elements is configured to be laterally translated relative to the other lens elements so as to change an optical power of the catadioptric lens assembly.

Abstract: A connection assembly is provided that includes a pin and a clip. The pin includes a head portion having two spaced flanges defining a slot therebetween, a tail portion defining a bulb, and a shaft extending between the head and tail portion. The clip includes a plurality of resilient fingers extending radially inward and a central cavity. The pin extends through the central cavity of the clip and the resilient fingers receives and rotationally engages with the bulb of the pin. In one form, the connection assembly connects a molded doghouse to an adjacent part.

Abstract: An apparatus for use with a head wearable display includes a curved eyepiece for guiding display light received at an input surface peripherally located from a viewing region and emitting the display light along an eye-ward direction in the viewing region. The curved eyepiece includes an optical combiner, an eye-ward facing surface that is concave, a world facing surface that is convex, and a curved lightguide disposed between the eye-ward facing and world facing surfaces to guide the display light via total internal reflections from the input surface to the viewing region. The optical combiner is disposed within the curved eyepiece at the viewing region to redirect the display light towards the eye-ward direction. The optical combiner includes a pattern of reflective elements separated by interstitial regions. The interstitial regions pass ambient light incident through the world facing surface such that the viewing region is partially see-through.

Abstract: A system includes an electronic display for emitting light toward an eye-ward side of the system. A beam splitter receives emitted light from the display. The beam splitter includes a polarization beam splitting (PBS) film and a mirror coating to generate two orthogonal polarization states with different optical paths thereby creating a first focal plane and a second focal plane at the eye-ward side of the system. At least one liquid crystal switch is positioned to receive light from the display in a light path between the display and the eye-ward side of the system.

Abstract: A vehicle includes a water collection system including a deployable channel movable between a stowed position and a deployed position for capturing water, a filter for filtering the water collected by the deployable channel, and a tank for storing the water filtered by the filter.

Abstract: Disclosed herein are new crystalline forms of valbenazine ditosylate designated Form D and Form E, which are characterized using one or more analytical methods, such as X-ray Powder Diffraction analysis. Further disclosed herein are crystalline Form D valbenazine ditosylate in the form of a dichloromethane solvate, and crystalline Form E valbenazine ditosylate in the form of a hydrate. Also disclosed are pharmaceutical compositions comprising these new crystalline forms, and methods of using those compositions for the treatment of various disease states and conditions, including hyperkinetic disorder, such as drug-induced tardive dyskinesia and Tourette's syndrome.

Abstract: A freeform projection display includes an optical emitter configured to output one or more wavelengths of light and an optical diffuser optically coupled to receive and disperse the one or more wavelengths of light from the optical emitter, wherein the optical diffuser has at least one radius of curvature. The freeform projection display further includes a refractive lens optically coupled to receive the one or more wavelengths of light from the optical diffuser and to project the one or more wavelengths of light. The freeform projection display further may include a light modulator disposed between the optical emitter and the optical diffuser, wherein the light modulator oscillates to project the image on the optical diffuser. An illuminated area of the optical diffuser is dimensioned so that the image produced by the light modulator fills an aperture of the refractive lens.

Abstract: The present invention relates to a method for measuring circulating cells in superficial body fluids by means of high-frequency-based device. The method can be used for detecting circulating cells in the fluids of an individual without the necessity of extracting a sample of the individual, being useful as a diagnostic tool and for monitoring the effectiveness of a treatment administered to an individual suffering from a viral, protozoal, fungal and/or bacterial disease.

Abstract: A near-eye display system includes a display panel to emit display light representative of a display image and a lens assembly disposed along an optical axis. The lens assembly includes a first phase mask plate having a first major surface facing the display and a second major surface opposite the first major surface, the second major surface implementing a first freeform Fresnel lens structure, and further includes a second phase mask plate adjacent and parallel to the first phase mask plate and having a third major surface facing the second major surface and an opposing fourth majors surface, the third major surface implementing a second freeform Fresnel lens structure. A pose of at least one of the first and second phase mask plates relative to the other is configured to be adjusted so as to adjust an optical power of the lens assembly.

Abstract: Optical assemblies for use in virtual and augmented reality environments are described. The optical assemblies may include lenses, filter stacks, cameras, and image projecting devices. For example, the optical assemblies may include at least one lens, a first filter stack between the at least one lens and an image projecting device, a second filter stack between the first filter stack and the image projecting device, and a camera configured to capture images of an infrared reflection of light through the at least one lens.

Abstract: An eye tracking system includes a light guide comprising a first eye-facing surface, a second surface, a third surface, and a plurality of facets formed in the second surface. The facets reflect a portion of light incident on a user eye into the light guide, which is positioned proximate to the user eye and between the user eye and a display. A surface of a compensator may be shaped complementary to the second surface of the light guide and placed proximate to the light guide. A camera or image sensor is oriented toward the third surface of the light guide and captures an image based on internally reflected light. An IR light source may be included. The image sensor may be an IR image sensor. Based on the image, a pose of the user eye is determined. A faceted light guide assembly may include a reflective coating adjacent the facets.