Patents by Inventor Oscar Mauricio Perez Leal

Oscar Mauricio Perez Leal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis and treatment of chronic obstructive pulmonary disease (COPD) based on elevated levels of extracellular H3 protein
    Patent number: 9933435
    Abstract: Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: April 3, 2018
    Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Salim Merali, Camilo Moncada, Steven G. Kelsen, Carlos A. Barrero, Oscar Mauricio Perez Leal
  • SSAT mRNA translation repression and activation
    Patent number: 9585380
    Abstract: The invention provides an isolated nucleic acid having a sequence encoding a spermidine/spermine acetyltransferase (“SSAT”), wherein translation of an mRNA comprising the encoded SSAT has increased basal translation and increased stimulated translation, compared to a wild-type mRNA encoding SSAT. Methods of use for the nucleic acid are also provided. Methods and compositions are also provided for reducing ischemia-reperfusion injury in organs or tissue for transplantation.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: March 7, 2017
    Assignee: TEMPLE UNIVERSITY—Of The Commonwealth System of Higher Education
    Inventors: Salim Merali, Oscar Mauricio Perez Leal, Magid Abou-Gharbia, Wayne E. Childers
  • Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease (COPD)
    Publication number: 20160187353
    Abstract: Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD.
    Type: Application
    Filed: February 16, 2016
    Publication date: June 30, 2016
    Inventors: Salim Merali, Camilo Moncada, Steven G. Kelsen, Carlos A. Barrero, Oscar Mauricio Perez Leal
  • Diagnosis and treatment of chronic obstructive pulmonary disease (COPD)
    Patent number: 9291626
    Abstract: Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: March 22, 2016
    Assignee: TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Salim Merali, Camilo Moncada, Steven G. Kelsen, Carlos A. Barrero, Oscar Mauricio Perez Leal
  • DIAGNOSIS AND TREATMENT OF COPD
    Publication number: 20140294843
    Abstract: Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD.
    Type: Application
    Filed: May 11, 2012
    Publication date: October 2, 2014
    Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Salim Merali, Camilo Moncada, Steven G. Kelsen, Carlos A. Barrero, Oscar Mauricio Perez Leal
  • SSAT mRNA TRANSLATION REPRESSION AND ACTIVATION
    Publication number: 20140234827
    Abstract: The invention provides an isolated nucleic acid having a sequence encoding a spermidine/spermine acetyltransferase (“SSAT”), wherein translation of an mRNA comprising the encoded SSAT has increased basal translation and increased stimulated translation, compared to a wild-type mRNA encoding SSAT. Methods of use for the nucleic acid are also provided. Methods and compositions are also provided for reducing ischemia-reperfusion injury in organs or tissue for transplantation.
    Type: Application
    Filed: August 31, 2012
    Publication date: August 21, 2014
    Applicant: TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Salim Merali, Oscar Mauricio Perez Leal, Magid Abou-Gharbia, Wayne E. Childers