Patents by Inventor Oskar Nagele

Oskar Nagele has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL MICROPARTICLES
    Publication number: 20130236550
    Abstract: Microparticles consisting of (a) a matrix with a mixture of (a1)) at least one hydrophobic, biologically degradable polymer and (a2) optionally at least one water-soluble polymer, (b) a pharmaceutical active ingredient distributed in the matrix, and (c) in addition at least one water-insoluble, surface-active substance from the group of lecithins and phospholipids, distributed in the matrix, and a three-phase emulsion process for their preparation.
    Type: Application
    Filed: April 26, 2013
    Publication date: September 12, 2013
    Applicant: NOVARTIS AG
    Inventors: Michael Ausborn, Olivier Lambert, Oskar Nagele
  • Pharmaceutical microparticles
    Patent number: 8460709
    Abstract: Microparticles consisting of (a) a matrix with a mixture of (a1) at least one hydrophobic, biologically degradable polymer and (a2) optionally at least one water-soluble polymer, (b) a pharmaceutical active ingredient distributed in the matrix, and (c) in addition at least one water-insoluble, surface-active substance from the group of lecithins and phospholipids, distributed in the matrix, and a three-phase emulsion process for their preparation.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: June 11, 2013
    Assignee: Novartis AG
    Inventors: Michael Ausborn, Olivier Lambert, Oskar Nagele
  • PHARMACEUTICAL MICROPARTICLES
    Publication number: 20120107408
    Abstract: Microparticles consisting of (a) a matrix with a mixture of (a1) at least one hydrophobic, biologically degradable polymer and (a2) optionally at least one water-soluble polymer, (b) a pharmaceutical active ingredient distributed in the matrix, and (c) in addition at least one water-insoluble, surface-active substance from the group of lecithins and phospholipids, distributed in the matrix, and a three-phase emulsion process for their preparation.
    Type: Application
    Filed: January 11, 2012
    Publication date: May 3, 2012
    Inventors: Michael Ausborn, Olivier Lambert, Oskar Nagele
  • Pharmaceutical microparticles
    Patent number: 8110224
    Abstract: Microparticles consisting of (a) a matrix with a mixture of (a1) at least one hydrophobic, biologically degradable polymer and (a2) optionally at least one water-soluble polymer, (b) a pharmaceutical active ingredient distributed in the matrix, and (c) in addition at least one water-insoluble, surface-active substance from the group of lecithins and phospholipids, distributed in the matrix, and a three-phase emulsion process for their preparation.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: February 7, 2012
    Assignee: Novartis AG
    Inventors: Michael Ausborn, Olivier Lambert, Oskar Nagele
  • Pharmaceutical microparticles
    Publication number: 20080279955
    Abstract: Microparticles consisting of (a) a matrix with a mixture of (a1) at least one hydrophobic, biologically degradable polymer and (a2) optionally at least one water-soluble polymer, (b) a pharmaceutical active ingredient distributed in the matrix, and (c) in addition at least one water-insoluble, surface-active substance from the group of lecithins and phospholipids, distributed in the matrix, and a three-phase emulsion process for their preparation.
    Type: Application
    Filed: July 17, 2008
    Publication date: November 13, 2008
    Inventors: Michael Ausborn, Olivier Lambert, Oskar Nagele
  • Pharmeutical microparticles
    Publication number: 20050152980
    Abstract: Microparticles consisting of (a) a matrix with a mixture of (a1) at least one hydrophobic, biologically degradable polymer and (a2) optionally at least one water-soluble polymer, (b) a pharmaceutical active ingredient distributed in the matrix, and (c) in addition at least one water-insoluble, surface-active substance from the group of lecithins and phospholipids, distributed in the matrix, and a three-phase emulsion process for their preparation.
    Type: Application
    Filed: March 12, 2003
    Publication date: July 14, 2005
    Inventors: Michael Ausborn, Olovier Lambert, Oskar Nagele
  • Organic compounds
    Patent number: 6204308
    Abstract: An emulsion-based method of microencapsulating an active agent wherein a water-in-oil emulsion, containing a matrix-forming polymer and an active agent, is dispersed in an aqueous external phase to form a microencapsulated product.
    Type: Grant
    Filed: March 1, 1999
    Date of Patent: March 20, 2001
    Assignee: Novartis AG
    Inventors: Michael Ausborn, David Bodmer, Oskar Nagele, Laurent Marchal
  • Sustained release formulations of water soluble peptides
    Patent number: 5876761
    Abstract: The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide) glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 2, 1999
    Assignee: Novartis AG
    Inventors: David Bodmer, Jones W. Fong, Thomas Kissel, Hawkins V. Maulding, Oskar Nagele, Jane E. Pearson
  • Sustained release formulations of water soluble peptides
    Patent number: 5688530
    Abstract: The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide) glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 18, 1997
    Assignee: Novartis AG
    Inventors: David Bodmer, Jones W. Fong, Thomas Kissel, Hawkins V. Maulding, Oskar Nagele, Jane E. Pearson
  • Sustained release formulations of water soluble peptides
    Patent number: 5639480
    Abstract: The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide)glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 17, 1997
    Assignee: Sandoz Ltd.
    Inventors: David Bodmer, Jones W. Fong, Thomas Kissel, Hawkins V. Maulding, Oskar Nagele, Jane E. Pearson
  • Sustained release formulations of water soluble peptides
    Patent number: 5538739
    Abstract: The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide) glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.
    Type: Grant
    Filed: January 18, 1991
    Date of Patent: July 23, 1996
    Assignee: Sandoz Ltd.
    Inventors: David Bodmer, Jones W. Fong, Thomas Kissel, Hawkins V. Maulding, Jr., Oskar Nagele, Jane E. Pearson