Patents by Inventor Osmond D'Cruz

Osmond D'Cruz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vanadium (IV) metallocene complexes having spermicidal activity
    Patent number: 6319947
    Abstract: Novel spermicidal compounds which are organometallic cyclopentadienyl metal complexes, particularly vanadium IV complexes, are described including corresponding contraceptive and therapeutic compositions and method for providing contraception and selective killing of testicular germ cells. Included among the vanadium complexes are vanadocene dichloride, vanadocene dibromide, bis (methyl cyclopentadienyl) vanadium dichloride, vanadocene diiodide, vanadocene di-pseudobalides, and others. Most active found was vanadocene diselenocyanate.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: November 20, 2001
    Assignee: Parker Hughes Institute
    Inventors: Osmond D'Cruz, Phalguni Ghosh, Fatih M. Uckun
  • Oxy-vanadium (IV) complexes having spermicidal activity
    Patent number: 6245808
    Abstract: Organometallic oxovanadium (IV) complexes having potent spermicidal activity, particularly those having at least one bidentate ligand. Preferred compounds are stable oxovanadium (IV) complexes having, as ancillary ligands linked via nitrogen or oxygen-metal bonds, bis and/or mono-1,10-phenanthroline; 2,2′-bipyridyl; or 2-hydroxyacetophenone.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: June 12, 2001
    Assignee: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Osmond D'Cruz, Wanhong Dong
  • Spermicidally active 5-halo-6-alkoxy-5,6-dihydro-2?,3?-dideoxy-uridines and their pharamaceutical compositions
    Patent number: 6191120
    Abstract: Contraceptive activity as well as anti-viral protection can be provided by contraceptive compositions containing a pyrimidine-based nucleoside or nucleotide exhibiting spermicidal or sperm-immobilizing activity. In one example, the active ingredient contains a thymine ring (e.g. AZT) that has 5-halo, 6-alkoxy substitution. Additional improvements in anti-HIV activity for certain AZT derivatives are seen by providing the pentose ring of AZT with aryl phosphate substitution.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: February 20, 2001
    Assignee: Wayne Hughes Institute
    Inventors: Osmond D'Cruz, Fatih M. Uckun, Taracad Venkatachalam
  • Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
    Patent number: 6136335
    Abstract: Novel phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity as well as anti-viral activity. These novel compounds can be incorporated within contraceptive compositions to provide for spermicidal or sperm-immobilizing activity.
    Type: Grant
    Filed: December 31, 1998
    Date of Patent: October 24, 2000
    Assignee: Hughes Institute
    Inventors: Fatih M. Uckun, Osmond D'Cruz
  • Vanadium (IV) metallocene complexes having sperm motility inhibiting activity
    Patent number: 6051603
    Abstract: Novel spermicidal compounds which are organometallic cyclopentadienyl metal complexes, particularly vanadium IV complexes, are described including corresponding contraceptive and therapeutic compositions and method for providing contraception and selective killing of testicular germ cells. Included among the vanadium complexes are vanadocene dichloride, vanadocene dibromide, bis (methyl cyclopentadienyl) vanadium dichloride, vanadocene diiodide, vanadocene di-pseudohalides, and others. Most active found was vanadocene diselenocyanate.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: April 18, 2000
    Assignee: Wayne Hughes Institute
    Inventors: Osmond D'Cruz, Phalguni Ghosh, Fatih M. Uckun