Patents by Inventor Osvaldo A. Flores

Osvaldo A. Flores has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HCV RNA-dependent RNA polymerase
    Patent number: 7569374
    Abstract: The present invention features NS5B polypeptides from different clinically important HCV genotypes. The polypeptides can be used individually, or as part of a panel of RNA-dependent RNA polymerases, to evaluate the effectiveness of a compound to inhibit NS5B activity.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: August 4, 2009
    Assignee: Merck & Co., Inc.
    Inventors: Donald J. Graham, Amy L. Simcoe, Steven W. Ludmerer, Osvaldo A. Flores, Robert L. LaFemina
  • HCV RNA-dependent RNA polymerase
    Publication number: 20080187903
    Abstract: The present invention features NS5B polypeptides from different clinically important HCV genotypes. The polypeptides can be used individually, or as part of a panel of RNA-dependent RNA polymerases, to evaluate the effectiveness of a compound to inhibit NS5B activity.
    Type: Application
    Filed: December 17, 2007
    Publication date: August 7, 2008
    Inventors: Donald J. Graham, Amy L. Simcoe, Steven W. Ludmerer, Osvaldo A. Flores, Robert L. LaFemina
  • HCV RNA-dependent RNA polymerase
    Patent number: 7329732
    Abstract: The present invention features NS5B polypeptides from different clinically important HCV genotypes. The polypeptides can be used individually, or as part of a panel of RNA-dependent RNA polymerases, to evaluate the effectiveness of a compound to inhibit NS5B activity.
    Type: Grant
    Filed: January 6, 2005
    Date of Patent: February 12, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Donald J. Graham, Amy L. Simcoe, Steven W. Ludmerer, Osvaldo A. Flores, Robert L. LaFemina
  • Hcv rna dependent rna polymerase
    Publication number: 20070149761
    Abstract: The present invention features NS5B polypeptides from different clinically important HCV genotypes. The polypeptides can be used individually, or as part of a panel of RNA-dependent RNA polymerases, to evaluate the effectiveness of a compound to inhibit NS5B activity.
    Type: Application
    Filed: January 6, 2005
    Publication date: June 28, 2007
    Inventors: Donald Graham, Amy Simcoe, Steven Ludmerer, Osvaldo Flores, Robert LaFemina
  • Assays to monitor amyloid precursor protein processing
    Publication number: 20060270841
    Abstract: The present invention provides DNA constructs, genetically engineered host cells, and methods for identifying inhibitors of amyloid precursor protein (APP) processing. The methods provide for the convenient identification, in a single assay, of inhibitors of ?-secretase and ?-secretase as well as other forms of APP processing. The methods rely on fusion proteins of APP and transcription factors in which APP processing releases the transcription factors, allowing the transcription factors to activate transcription of a reporter gene. Inhibitors are identified as substances that block or diminish transcription factor release from the fusion protein, thereby causing a diminution of reporter gene readout.
    Type: Application
    Filed: February 25, 2003
    Publication date: November 30, 2006
    Inventors: Amy Espeseth, Marc Ferrer, Osvaldo Flores, Daria Hazuda, James Inglese, Michael Miller, Bruce Register, Xiao-Ping Shi, Adam Simon, Paul Zuck
  • Method to confer cell culture replication activity to different hepatitis c virus isolates
    Publication number: 20060228697
    Abstract: The present invention features methods for producing HCV replicons using HCV encoding sequences from different isolates. The featured methods are based on the discovered importance of NS3 amino acid position 470 in conferring cell culture replication activity to different HCV isolates.
    Type: Application
    Filed: February 9, 2004
    Publication date: October 12, 2006
    Inventors: Jay Grobler, Osvaldo Flores, Eric Markel
  • Hepatitis c virus assay systems
    Publication number: 20050181356
    Abstract: The present invention features assays employing a beta-lactamase reporter system, an HCV replicon enhanced cell, and/or a chimeric HCV replicon containing a 3? UTR based on the HCV-1a 3? UTR.
    Type: Application
    Filed: April 11, 2003
    Publication date: August 18, 2005
    Inventors: Osvaldo Flores, Jay Grobler, Edward Murray, Paul Zuck
  • High throughput in vitro screening assays for transcription modulators
    Patent number: 6183956
    Abstract: High-throughput in vitro assays are provided for identifying modulators of transcription activity and RNA expression. New assays, related compositions, apparatus and integrated systems are provided.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: February 6, 2001
    Assignee: Tularik, Incorporated
    Inventors: Mohanram Sivaraja, Berta Strulovici, Osvaldo A. Flores