Patents by Inventor Otis Crandell Addington

Otis Crandell Addington has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SCF extract containing cardiac glycoside
    Patent number: 8394434
    Abstract: A supercritical fluid (SCF) extract of a cardiac glycoside-containing plant mass is provided. The extract can be included in a pharmaceutical composition containing an extract-solubilizing amount of solubilizer. Oleandrin is included within the extract when a cardiac glycoside-containing plant, such as Nerium oleander, is extracted by SCF extraction. The extract can also contain one or more other SCF extractable pharmacologically active agents. The composition can be used to treat a wide range of disorders that are therapeutically responsive to a cardiac glycoside.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: March 12, 2013
    Assignee: Phoenix Biotechnology, Inc.
    Inventors: Otis Crandell Addington, Feng Zhang, John J. Koleng
  • Method of determining the probability of a therapeutic response in cancer chemotherapy with cardiac glycoside
    Patent number: 8367363
    Abstract: A prognostic assay and kit and method of use thereof are provided. The kit and assay are used to determine the likelihood of a diseased cell or tissue having a therapeutic response to treatment with a cardiac glycoside in a disease having an etiology associated with excessive cell proliferation. The kit and assay are used to determine the ratio of isoforms of the ? subunit of Na, K-ATPase obtained from the diseased cell or tissue. The kit can be used to predict the therapeutic responsiveness of cancer or tumor in a subject to treatment with a cardiac glycoside. The kit and assay can be incorporated in a method of treating a disease or disorder having an etiology associated with excessive cell proliferation with a composition comprising a cardiac glycoside.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: February 5, 2013
    Assignee: Phoenix Biotechnology, Inc.
    Inventors: Otis Crandell Addington, Robert A. Newman, Peiying Yang
  • SCF extract containing cardiac glycoside
    Patent number: 8187644
    Abstract: A supercritical fluid (SCF) extract of a cardiac glycoside-containing plant mass is provided. The extract can be included in a pharmaceutical composition containing an extract-solubilizing amount of solubilizer. Oleandrin is included within the extract when a cardiac glycoside-containing plant, such as Nerium oleander, is extracted by SCF extraction. The extract can also contain one or more other SCF extractable pharmacologically active agents. The composition can be used to treat a wide range of disorders that are therapeutically responsive to a cardiac glycoside.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: May 29, 2012
    Assignee: Phoenix Biotechnology Inc.
    Inventor: Otis Crandell Addington
  • Method of Determining the Probability of a Therapeutic Response in Cancer Chemotherapy With Cardiac Glycoside
    Publication number: 20100317541
    Abstract: A prognostic assay and kit and method of use thereof are provided. The kit and assay are used to determine the likelihood of a diseased cell or tissue having a therapeutic response to treatment with a cardiac glycoside in a disease having an etiology associated with excessive cell proliferation. The kit and assay are used to determine the ratio of isoforms of the ? subunit of Na, K-ATPase obtained from the diseased cell or tissue. The kit can be used to predict the therapeutic responsiveness of cancer or tumor in a subject to treatment with a cardiac glycoside. The kit and assay can be incorporated in a method of treating a disease or disorder having an etiology associated with excessive cell proliferation with a composition comprising a cardiac glycoside.
    Type: Application
    Filed: May 4, 2010
    Publication date: December 16, 2010
    Applicant: PHOENIX BIOTECHNOLOGY, INC.
    Inventors: Otis Crandell ADDINGTON, Robert A. NEWMAN, Peiying YANG
  • SCF Extract Containing Cardiac Glycoside
    Publication number: 20080200401
    Abstract: A supercritical fluid (SCF) extract of a cardiac glycoside-containing plant mass is provided. The extract can be included in a pharmaceutical composition containing an extract-solubilizing amount of solubilizer. Oleandrin is included within the extract when a cardiac glycoside-containing plant, such as Nerium oleander, is extracted by SCF extraction. The extract can also contain one or more other SCF extractable pharmacologically active agents. The composition can be used to treat a wide range of disorders that are therapeutically responsive to a cardiac glycoside.
    Type: Application
    Filed: January 24, 2008
    Publication date: August 21, 2008
    Applicant: PHOENIX BIOTECHNOLOGY, INC.
    Inventor: Otis Crandell ADDINGTON