Patents by Inventor Otto Engelfried

Otto Engelfried has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • .DELTA..sup.9 (11) -5.alpha.-D-homo-20-keto steroids
    Patent number: 4097678
    Abstract: 3.alpha.-Hydroxy and 3.alpha.-acyloxy- .DELTA..sup.9(11) -5.alpha.-D-homo-20-ketopregnenes of the formula ##STR1## wherein R is hydrogen or acyl, R.sub.1 is hydrogen or methyl and R.sub.2 is methyl or ethyl, are produced by esterifying a corresponding 3.beta.-hydroxy-5.alpha.-20-keto pregnane of the formula ##STR2## wherein R.sub.1 and R.sub.2 have the values given above, with m-iodo-benzoic acid with inversion of the 3.beta.-oxy group to a 3.alpha.-oxy group; chlorinating the thus-produced 3.alpha.-m-iodobenzoyl ester with dichloroiodobenzene under irradiation; and treating the reaction product with a dehydrohalogenating silver salt. Optionally thereafter, the 3.alpha.-iodobenzoyl group is split off in a conventional manner to produce the corresponding 3.alpha.-hydroxy steroid and optionally the thus-produced 3.alpha.-hydroxy steroid is esterified to produce a desired 3-ester thereof.
    Type: Grant
    Filed: June 8, 1976
    Date of Patent: June 27, 1978
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Kerb, Rudolf Wiechert, Otto Engelfried
  • .DELTA..sup.9(11) -5.alpha.-20-KETO STEROIDS AND PROCESS FOR THEIR PRODUCTION
    Patent number: 4061661
    Abstract: 3.alpha.-Hydroxy and 3.alpha.-acyloxy- .DELTA..sup.9(11) -5.alpha.-20-ketopregnenes of the formula ##STR1## wherein R is hydrogen or acyl, R.sub.1 is hydrogen or methyl and R.sub.2 is methyl or ethyl, are produced by esterifying a corresponding 3.beta.-hydroxy-5.alpha.-20-keto pregnane of the formula ##STR2## wherein R.sub.1 and R.sub.2 have the values given above, with m-iodobenzoic acid with inversion of the 3.beta.-oxy group to a 3.alpha.-oxy group; chlorinating the thus-produced 3.alpha.-m-iodobenzoyl ester with dichloroiodobenzene under irradiation; and treating the reaction product with a dehydrohalogenating silver salt. Optionally thereafter, the 3.alpha.-iodobenzoyl group is split off in a conventional manner to produce the corresponding 3.alpha.-hydroxy steroid and optionally the thus-produced 3.alpha.-hydroxy steroid is esterified to produce a desired 3-ester thereof.
    Type: Grant
    Filed: June 8, 1976
    Date of Patent: December 6, 1977
    Assignee: Schering Aktiengesellschaft
    Inventors: Rudolf Wiechert, Ulrich Kerb, Otto Engelfried
  • D-homo-20-ketopregnanes and method for inducing anesthesia or narcosis
    Patent number: 4056633
    Abstract: D-homo-20-ketopregnanes of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, alkyl, alkoxy, or azido;R.sub.2 is oxygen, ##STR2## and R.sub.7 is hydrogen, lower alkyl, or acyl of up to 5 carbon atoms; R.sub.3 is hydrogen or methylR.sub.4 is oxygen, two hydrogens, ##STR3## R.sub.5 is hydrogen, hydroxy, alkoxy, azido, mercapto, thiocyano, cyano, dialkylamino, morpholino, thiomorpholino, or piperazino;R.sub.6 is methyl or ethyl;The hydrogen atom in the 5-position is of the .alpha.- or .beta.-configuration;And acid addition salts thereof, possess narcotic-anesthetic activity.
    Type: Grant
    Filed: December 17, 1975
    Date of Patent: November 1, 1977
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Kerb, Rudolf Wiechert, Helmut Wachtel, Otto Engelfried, Klaus Kieslich
  • 18-Methyl-19-nor-20-ketopregnanes and process for the preparation thereof
    Patent number: 4029777
    Abstract: 18-Methyl-19-nor-20-keto steroids of the formula ##STR1## wherein R.sub.1 and R.sub.2 collectively are an oxygen atom, or each is hydrogen, or one of R.sub.1 and R.sub.2 is hydrogen and the other is hydroxy, and R.sub.3 is a ketonic oxygen atom or two hydrogen atoms, possess CNS-depressant activity, especially anesthetic-narcotic activity.
    Type: Grant
    Filed: August 5, 1975
    Date of Patent: June 14, 1977
    Assignee: Schering Aktiengesellschaft
    Inventors: Otto Engelfried, Ulrich Kerb, Rudolf Wiechert, Helmut Wachtel, Dieter Palenschat, Reinhard Horowski, Gert Paschelke, Wolfgang Kehr
  • Radioactively labeled steroid derivatives
    Patent number: 3935245
    Abstract: Steroids bearing the substituent --X-NR.sub.1 R.sub.2 wherein --NR.sub.1 R.sub.2 is a tritium of carbon-14 labeled amino or amino-acid group and --X-- is --R.sub.3 --, --OCOR.sub.3 --, =N--O--R.sub.3 -- or --NHCOR.sub.3 -- wherein R.sub.3 is --(CH.sub.2).sub.n CO-- in which n is 0-4, are useful as diagnostic agents.
    Type: Grant
    Filed: June 4, 1974
    Date of Patent: January 27, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Otto Engelfried, Bob Nieuweboer, Karl Petzoldt, Ulrich Kerb, Klaus Lubke