Patents by Inventor Otto Grawinger
Otto Grawinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 4335123Abstract: A 1-acyl-8-[2,3-epoxypropoxy]- and/or 1-acyl-8-[3-halo-2-hydroxypropoxy]-1,2,3,4-tetrahydroquinoline are reacted with primary and secondary amines to obtain corresponding physiologically-active 1-acyl-8-[3-amino-2-hydroxypropoxy]-1,2,3,4-tetrahydroquinolines and pharmacologically-acceptable acid-addition salts thereof. These compounds are useful as such or in conventional medicament compositions for treating those afflicted with heart ailments and/or hypertension.Type: GrantFiled: August 15, 1980Date of Patent: June 15, 1982Assignee: Cassella AktiengesellschaftInventors: Otto Grawinger, Thomas Raabe, Rudi Beyerle, Josef Scholtholt, Rolf-Eberhard Nitz
-
Patent number: 4247456Abstract: Water-insoluble monoazo dyes of the formula ##STR1## produced by reacting a diazotized amine of the benzene, naphthalene, diphenyl, diphenylmethane or heterocyclic series which is free from water solubilizing groups with the appropriate 6-hydroxy-2-pyridone and the utility thereof for the dyeing and printing of synthetic fabric materials to yellow to red shades having excellent fastness to light and sublimation.Type: GrantFiled: November 19, 1976Date of Patent: January 27, 1981Assignee: Cassella AktiengesellschaftInventors: Hanswilli von Brachel, Ernst Heinrich, Otto Grawinger, Karl Hintermeier, Horst Kindler
-
Patent number: 4216314Abstract: Physiologically-acceptable substituted 1,2-ethylenediamines and 1,3-propylenediamines, in free-base and in acid-addition-salt form, have highly pronounced and cardioselective .beta.-adrenolytic action, antiarrhythmic action and hypotensive action on administration to humans. The diamines are, more specifically, N-[3-aryloxy-2-hydroxypropyl]-N'-[1,3-(di-R.sup.3)-2,4-dioxypyrimid-6-yl] (ethylene or propylene)diamines wherein R.sup.3 is --H or lower alkyl and the aryl nucleus is either further unsubstituted, further monosubstituted or further disubstituted.The compounds are prepared, e.g, by reacting a corresponding N-[3-phenoxy-2-hydroxypropyl] (ethylene or propylene)diamine with a corresponding 6-chloropyrimidine-2,4-dione in a suitable medium containing an acid-binding agent.Type: GrantFiled: May 2, 1978Date of Patent: August 5, 1980Assignee: Cassella Farbwerke Mainkur AktiengesellschaftInventors: Thomas Raabe, Otto Grawinger, Josef Scholtholt, Eckhard Schraven
-
Patent number: 4088764Abstract: The present invention relates to new pharmacologically valuable derivatives of 1-phenoxy-3-amino-propan-2-ol having the formula ##STR1## Wherein A denotes -CH.sub.2 -alkoxy, -O-alkoxyalkyl, -O-hydroxyalkyl, or ##STR2## R.sub.1 denotes hydrogen or methyl, Het denotes the radical of a pyrrole, pyrazole, imidazole, furane, thiophene, thiazole, pyridine, pyridazine, pyrimidine or pyrazine, which can additionally be substituted by one or more methyl groups, said radical is linked through a C atom, and R.sub.2 and R.sub.3 denote hydrogen, alkyl, alkenyl or cycloalkyl or conjointly with the N atom to which they are linked, and optionally with a further oxygen or sulfur hetero-atom, denote a saturated, 5-membered or 6-membered, monocyclic, heterocyclic structure, and alkyl radicals contain 1 to 4 carbon atoms, alkoxy radicals contain 1 to 4 carbon atoms, alkenyl radicals contain 3 or 4 carbon atoms and cycloalkyl radicals contain 5 to 7 carbon atoms; and aldehyde condensation products and acid addition salts thereof.Type: GrantFiled: December 10, 1974Date of Patent: May 9, 1978Assignee: Cassella Farbwerke Mainkur AktiengesellschaftInventors: Thomas Raabe, Otto Grawinger, Josef Scholtholt, Rolf-Eberhard Nitz, Eckhard Schraven
-
Patent number: 4066768Abstract: The present invention relates to new pharmacologically valuable derivatives of 1-phenoxy-3-amino-propan-2-ol having the formula ##STR1## wherein X denotes ##STR2## A denotes --CH.sub.2 --alkoxy, --O--alkoxyalkyl, --O--hydroxyalkyl or ##STR3## AN AROMATIC OR QUASI-AROMATIC, 5-MEMBERED OR 6-MEMBERED, MONOCYCLIC RING WHICH IS LINKED THROUGH A C atom which has one or 2 nitrogen, oxygen and/or sulphur hetero-atoms and which can be substituted additionally by one or more methyl groups, and R.sub.2 and R.sub.Type: GrantFiled: March 24, 1976Date of Patent: January 3, 1978Assignee: Cassella Farbwerke Mainkur AktiengesellschaftInventors: Thomas Raabe, Otto Grawinger, Josef Scholtholt, Rolf-Eberhard Nitz, Eckhard Schraven
-
Patent number: 4020071Abstract: The present invention relates to new pharmacologically valuable derivatives of 1-phenoxy-3-amino-propan-2-ol having the formula ##STR1## and the aldehyde condensation products and acid addition salts thereof wherein X is selected from the group consisting of ##STR2## wherein the phenyl ring I may have attached to it up to three similar or different substituents selected from the group consisting of alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, alkoxy, alkenyloxy, alkinyloxy, benzyloxy, phenyl, halogen and --NR.sub.1 R.sub.2, wherein R.sub.1 is selected from alkyl and acyl, and R.sub.2 is selected from hydrogen and alkyl; and to the production thereof by a method selected from (A) reacting 1-phenoxy-3-amino-propan-2-ol having the formula ##STR3## with a compound having the formula Y-X, wherein X has the above-defined meaning and Y is selected from halogen, --OH, --OK or --ONa; (B) reacting a compound of the formula ##STR4## with a compound of the formula H.sub.Type: GrantFiled: December 10, 1974Date of Patent: April 26, 1977Assignee: Cassella Farbwerke Mainkur AktiengesellschaftInventors: Thomas Raabe, Otto Grawinger, Josef Scholtholt, Rolf-Eberhard Nitz, Eckhard Schraven
-
Patent number: 3987036Abstract: The present invention relates to new pharmacologically valuable, basically substituted heterocyclic compounds of the formula ##EQU1## wherein X represents--N=N----ch=n-- ##EQU2## R represents an aliphatic, cycloaliphatic, araliphatic or aromatic amine radical having 2 to 10 carbon atoms or the radical of a 5, 6 or 7 ring-membered heterocyclic amine optionally containing an additional N, O or S hetero atom, the radical being attached through the nitrogen atom,R.sub.1 and R.sub.2 represent alkoxy groups containing 1 - 4 C-atoms, R.sub.3 represents lower alkyl having 1 - 3 C-atoms and m and n are 1, 2 or 3.The above derivatives are produced by acylating heterocyclic derivatives having the formula ##STR1## with an alkoxycinnamic acid of the general formula ##STR2## OR A FUNCTIONAL DERIVATIVE OF THE LATTER, OPTIONALLY IN THE PRESENCE OF AN ACID-BINDING AGENT, THE RADICALS R, R.sub.1, R.sub.2, n and m having the meanings set out above.Type: GrantFiled: July 15, 1974Date of Patent: October 19, 1976Assignee: Cassella Farbwerke Mainkur AktiengesellschaftInventors: Heinz Bender, Otto Grawinger, Adolf Stachel, deceased, by Ingeburg Lydia Katharina Stachel, heiress, Rudi Beyerle, Josef Scholtholt, Rolf-Eberhard Nitz
-
Patent number: 3969363Abstract: The present invention relates to new pharmacologically valuable derivatives of 1-phenoxy-3-amino-propan-2-ol having the formula ##EQU1## and the aldehyde condensation products and acid addition salts thereof wherein X is selected from the group consisting of ##EQU2## wherein the phenyl ring I may have attached to it up to three similar or different substituents selected from the group consisting of alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, alkoxy, alkenyloxy, alkinyloxy, benzyloxy, phenyl, halogen and --NR.sub.1 R.sub.2, wherein R.sub.1 is selected from alkyl and acyl, and R.sub.2 is selected from hydrogen and alkyl and n is 1, 2 or 3; and to the production thereof by a method selected from (A) reacting 1-phenoxy-3-amino-propan-2-ol having the formula ##EQU3## with a compound having the formula Y-X, wherein X has the above defined meaning and Y is selected from halogen, --OH, --OK or --ONa; (B) reacting a compound of the formula ##EQU4## with a compound of the formula H.sub.Type: GrantFiled: December 10, 1974Date of Patent: July 13, 1976Assignee: Cassella Farbwerke Mainkur AktiengesellschaftInventors: Thomas Raabe, Otto Grawinger, Josef Scholtholt, Rolf-Eberhard Nitz, Eckhard Schraven
-
Patent number: 3957749Abstract: Water-insoluble monoazo dyes of the formula ##SPC1##Produced by reacting a diazotized amine of the benzene, naphthalene, diphenyl, diphenylmethane or heterocyclic series which is free from water solubilizing groups with the appropriate 6-hydroxy-2-pyridone and the utility thereof for the dyeing and printing of synthetic fabric materials to yellow to red shades having excellent fastness to light and sublimation.Type: GrantFiled: June 5, 1972Date of Patent: May 18, 1976Assignee: Cassella Farbwerke Mainkur AktiengesellschaftInventors: Hanswilli von Brachel, Ernst Heinrich, Otto Grawinger, Karl Hintermeier, Horst Kindler