Patents by Inventor Otto Hromatka

Otto Hromatka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4544655
    Abstract: 4-Hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-6-trifluoromethyl-2H-thieno[2,3-e ]-1,2-thiazine 1,1-dioxide of the formula ##STR1## and its pharmaceutically acceptable salts which possess valuable pharmacodynamic properties are described. More particularly, the compound and its salts display antiinflammatory, analgesic and antirheumatic activities and they are readily accessible by reacting a corresponding alkyl ester with 2-aminopyridine and, if desired, subsequent salt formation.
    Type: Grant
    Filed: August 31, 1983
    Date of Patent: October 1, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Rudolf Pfister, Paul Zeller, Dieter Binder, Otto Hromatka
  • Patent number: 4230873
    Abstract: The invention relates to sulphothiophene-carboxylic acids of the following formula ##STR1## wherein A together with the two carbon atoms to which it is attached forms the group ##STR2## and the broken line represents the double bond present in group (a), R.sub.3 and R.sub.4 each represent a hydrogen atom or a lower alkyl group; and the halides and lower alkyl esters thereof.
    Type: Grant
    Filed: March 2, 1977
    Date of Patent: October 28, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Otto Hromatka, Dieter Binder
  • Patent number: 4224445
    Abstract: The present invention relates to compounds of the formula ##STR1## wherein A together with the two carbon atoms to which it is attached forms the group ##STR2## and the broken line represents the double bond in group (a); R.sub.1 represents a lower alkyl group; R.sub.2 represents the residue of an aromatic heterocyclic ring containing from 1 to 4 hetero atoms, which may be substituted by one or two lower alkyl groups, or a phenyl group which may be substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy and R.sub.3 and R.sub.4 each represent a hydrogen atom or a lower alkyl group.Also provided are methods for their preparation. The thienothiazine derivatives provided by this invention have anti-flammatory, analgesic and anti-rheumatic activity.
    Type: Grant
    Filed: October 30, 1978
    Date of Patent: September 23, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Otto Hromatka, Dieter Binder, Rudolf Pfister, Paul Zeller
  • Patent number: 4187303
    Abstract: Thienothiazine derivatives of the formula ##STR1## wherein A, R.sub.1 and R.sub.2 are as hereinafter set forth, and their tautomers are described. The thienothiazine derivatives are useful as anti-inflammatory, analgesic, antirheumatic and antithrombotic agents.
    Type: Grant
    Filed: August 15, 1978
    Date of Patent: February 5, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Otto Hromatka, Dieter Binder, Paul Zeller, Rudolf Pfister
  • Patent number: 4180662
    Abstract: Anti-inflammatory, analgesic, anti-rheumatic and anti-thrombotic thienothiazine derivatives having the formula ##STR1## wherein A together with the two carbon atoms forms the group ##STR2## and the dotted line indicates the double bond present in the first and last thieno structures above, R.sup.1 is lower alkyl, R.sup.2 is the radical of an aromatic heterocycle with 1 to 4 hetero atoms optionally substituted by one or two lower alkyl groups, or a phenyl radical optionally substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy, R.sup.3 is halogen and R.sup.3' is hydrogen or halogen,and pharmaceutically acceptable salts thereof are described.
    Type: Grant
    Filed: August 31, 1978
    Date of Patent: December 25, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Rudolf Pfister, Paul Zeller, Dieter Binder, Otto Hromatka
  • Patent number: 4177193
    Abstract: The present invention relates to compounds of the formula ##STR1## wherein A together with the two carbon atoms to which it is attached forms the group ##STR2## and the broken line represents the double bond in group (a); R.sub.1 represents a lower alkyl group; R.sub.2 represents the residue of an aromatic heterocyclic ring containing from 1 to 4 hetero atoms, which may be substituted by one or two lower alkyl groups, or a phenyl group which may be substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy and R.sub.3 and R.sub.4 each represent a hydrogen atom or a lower alkyl group.Also provided are methods for their preparation. The thienothiazine derivatives provided by this invention have anti-flammatory, analgesic and anti-rheumatic activity.
    Type: Grant
    Filed: October 30, 1978
    Date of Patent: December 4, 1979
    Assignee: Hoffman-La Roche Inc.
    Inventors: Otto Hromatka, Dieter Binder, Rudolf Pfister, Paul Zeller
  • Patent number: 4175085
    Abstract: Thienothiazine derivatives of the formula ##STR1## wherein R.sub.1 is lower alkyl; R.sub.2 is an unsubstituted aromatic heterocyclic radical which contains from 1 to 4 hetero atoms or one which is substituted by one or two lower alkyl groups, or is an unsubstituted phenyl radical or one substituted by halogen, hydroxy, lower alkyl, nitro, trifluoromethyl or lower alkoxy; and R.sub.3 and R.sub.4, independently, are hydrogen or lower alkyl,prepared inter alia, from novel intermediates, are described. The end products are useful as anti-inflammatory, analgesic and anti-rheumatic agents.
    Type: Grant
    Filed: March 2, 1978
    Date of Patent: November 20, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Dieter Binder, Otto Hromatka, Rudolf Pfister, Paul Zeller
  • Patent number: 4155913
    Abstract: Novel thienotriazolodiazepine derivatives and processes for their preparation are described. These compounds are useful as anticonvulsants, muscle-relaxants and sedatives.
    Type: Grant
    Filed: October 14, 1977
    Date of Patent: May 22, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Joseph Hellerbach, Paul Zeller, Dieter Binder, Otto Hromatka
  • Patent number: 4134898
    Abstract: The present invention relates to compounds of the formula ##STR1## wherein A together with the two carbon atoms to which it is attached forms the group ##STR2## AND THE BROKEN LINE REPRESENTS THE DOUBLE BOND IN GROUP (A); R.sub.1 represents a lower alkyl group; R.sub.2 represents the residue of an aromatic heterocyclic ring containing from 1 to 4 hetero atoms, which may be substituted by one or two lower alkyl groups, or a phenyl group which may be substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy and R.sub.3 and R.sub.4 each represent a hydrogen atom or a lower alkyl group.
    Type: Grant
    Filed: November 17, 1977
    Date of Patent: January 16, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Otto Hromatka, Dieter Binder, Rudolf Pfister, Paul Zeller
  • Patent number: 4090020
    Abstract: Thienothiazine derivatives of the formula ##STR1## wherein R.sub.1 is lower alkyl; R.sub.2 is an unsubstituted aromatic heterocyclic radical which contains from 1 to 4 hetero atoms or one which is substituted by one or two lower alkyl groups, or is an unsubstituted phenyl radical or one substituted by halogen, hydroxy, lower alkyl, nitro, trifluoromethyl or lower alkoxy; and R.sub.3 and R.sub.4, independently, are hydrogen or lower alkyl,Prepared inter alia, from novel intermediates, are described. The end products are useful as anti-inflammatory, analgesic and anti-rheumatic agents.
    Type: Grant
    Filed: February 9, 1977
    Date of Patent: May 16, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Dieter Binder, Otto Hromatka, Rudolf Pfister, Paul Zeller
  • Patent number: 4076709
    Abstract: The present invention relates to compounds of the formula ##STR1## wherein A together with the two carbon atoms to which it is attached forms the group ##STR2## AND THE BROKEN LINE REPRESENTS THE DOUBLE BOND IN GROUP (A); R.sub.1 represents a lower alkyl group; R.sub.2 represents the residue of an aromatic heterocyclic ring containing from 1 to 4 hetero atoms, which may be substituted by one or two lower alkyl groups, or a phenyl group which may be substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy and R.sub.3 and R.sub.4 each represent a hydrogen atom or a lower alkyl group.Also provided are methods for their preparation. The thienothiazine derivatives provided by this invention have anti-flammatory, analgesic and antirheumatic activity.
    Type: Grant
    Filed: August 21, 1975
    Date of Patent: February 28, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Otto Hromatka, Dieter Binder, Rudolf Pfister, Paul Zeller
  • Patent number: 4028373
    Abstract: Thiophene analogs of saccharine, i.e., the new compounds 2,3-dihydro-3-oxothieno-[3,4-d]-, -[2,3-d]- and -[3,2-d]-isothiazole-1,1-dioxide, and processes for their manufacture. The new compounds are excellent sweeteners and have no unpleasant taste.
    Type: Grant
    Filed: September 2, 1975
    Date of Patent: June 7, 1977
    Assignee: BASF Aktiengesellschaft
    Inventors: Otto Hromatka, Dieter Binder