Patents by Inventor Otto Isaac

Otto Isaac has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6300370
    Abstract: Camomile oil having a high cis- and trans-spiroether content is produced in a process which includes steam distillation or aqueous distillation of fresh camomile or an extraction residue of camomile.
    Type: Grant
    Filed: June 10, 1998
    Date of Patent: October 9, 2001
    Assignee: ASTA Medica Aktiengesellschaft
    Inventors: Reinhold Carle, Otto Isaac
  • Patent number: 5902587
    Abstract: Camomile oil having a high cis- and trans-spiroether content is produced in a process which includes steam distillation or aqueous distillation of fresh camomile or an extraction residue of camomile.
    Type: Grant
    Filed: July 1, 1992
    Date of Patent: May 11, 1999
    Assignee: ASTA Medica Aktiengesellschaft
    Inventors: Reinhold Carle, Otto Isaac
  • Patent number: 5204335
    Abstract: Ifosfamide lyophilizate consisting substantially of ifosfamide and 0.1 to 17 parts by weight of a hexitol.
    Type: Grant
    Filed: May 21, 1991
    Date of Patent: April 20, 1993
    Assignee: Asta Pharma Aktiengesellschaft
    Inventors: Dieter Sauerbier, Uwe-Peter Dammann, Otto Isaac
  • Patent number: 5158776
    Abstract: Solid oral ifosfamide formulations comprising a capsule containing a mass which consists essentially of the active substance ifosfamide and microcrystalline cellulose, or in the form of tablets which contain, in relation to one part by weight of ifosfamide,0.1-1.0 parts by weight of tribasic calcium phosphate and0.04-0.4 parts by weight of polyethylene glycol as well as in addition, related to the weight of the tablet5-60% by weight of a filling and flow regulating agent1-10% by weight of a disintegrant0.1-10% by weight of an antiadhesion agent and0.1-80% by weight of a binding agent.
    Type: Grant
    Filed: July 24, 1991
    Date of Patent: October 27, 1992
    Assignee: Asta Medica Aktiengesellschaft
    Inventors: Dieter Sauerbier, Jurgen Engel, Eckhard Milsmann, Klaus Molge, Otto Isaac
  • Patent number: 4959215
    Abstract: An ifosfamide-mesna lyophilizate consists substantially of ifosfamide, 0.1-1.0 parts by weight of mesna and 0.1 to 17 parts by weight of hexitol. The product is obtained by freeze drying an aqueous or aqueous-ethanolic solution of ifosfamide and mesna.
    Type: Grant
    Filed: March 20, 1989
    Date of Patent: September 25, 1990
    Assignee: Asta Pharma AG
    Inventors: Dieter Sauerbier, Otto Isaac, Wolfgang P. Brade
  • Patent number: 4786497
    Abstract: Improved camomile extracts are obtained by extraction of fresh camomile flowers with aqueous lower alkanols and wthout a subsequent heat treatment.
    Type: Grant
    Filed: September 8, 1987
    Date of Patent: November 22, 1988
    Assignee: Degussa Aktiengesellschaft
    Inventors: Otto Isaac, Reinhold Carle
  • Patent number: 4786498
    Abstract: This invention relates to the production of camomile extracts rich in flavone by extracting ordinary camomile drug together with added camomile wing petals.
    Type: Grant
    Filed: February 2, 1988
    Date of Patent: November 22, 1988
    Assignee: Degussa Aktiengesellschaft
    Inventors: Otto Isaac, Reinhold Carle, Bernd Dolle
  • Patent number: 4435563
    Abstract: There is provided a process for the recovery of pure hellebrin which comprises extracting a defatted hellebrin extract dissolved in a water-alkanol mixture or water-acetone mixture with a mixture of a lower alkanol or acetone and di-, tri-, or tetrachloromethane (or dichloroethane) evaporating the extraction agent in a vacuum and then heating with ethanol until the deposition of the first hellebrin crystals begins.
    Type: Grant
    Filed: May 11, 1982
    Date of Patent: March 6, 1984
    Assignee: Degussa Aktiengesellschaft
    Inventors: Gerhard Oepen, Karl-Heinz Mangartz, Norbert Seifried, Jurgen Engel, Otto Isaac
  • Patent number: 4218447
    Abstract: There are prepared compounds corresponding to the general formula: ##STR1## in which R represents a 2,2-dimethylethenyl; isopropyl; nonyl; a C.sub.3 -C.sub.6 -cycloalkyl radical; a phenyl group substituted by at least one nitro group, or a C.sub.1 -C.sub.6 -alkyl group containing a morpholine group attached thereto, said morpholine ring being substituted zero to twice by C.sub.1 -C.sub.6 -alkyl groups; R.sub.3 is --CHO or --CH.sub.2 OH, their optically active forms and their salts. The compounds have cardioactivity e.g., bradycardic effect and have local anethetic, spasmolytic and antiarythmic activity.
    Type: Grant
    Filed: April 9, 1979
    Date of Patent: August 19, 1980
    Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals Roessler
    Inventors: Otto Isaac, Klaus Posselt, Horst Uthemann, Klaus Thiemer
  • Patent number: 4038386
    Abstract: Compounds are prepared of the formula ##STR1## The compounds of the invention possess valuable pharmacodynamic properties. They especially have a positive inotropic effect which is particularly noted in oral or enteral application. In contrast to the known compounds the compounds of the invention have more favorable pharmacological or pharmaceutical properties.
    Type: Grant
    Filed: April 3, 1975
    Date of Patent: July 26, 1977
    Assignee: Deutsch Gold- und Silber-Scheideanstalt Vormals Roessler
    Inventors: Otto Isaac, Klaus Posselt, Horst Uthemann
  • Patent number: 4004976
    Abstract: The main sapogenins in the roots and rhizomes of Helleborous species are recovered by treating the roots and/or rhizomes or drugs or extracts made therefrom with cellulase, hemicellulase or .beta.-glucosidase.
    Type: Grant
    Filed: April 7, 1975
    Date of Patent: January 25, 1977
    Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals Roessler
    Inventor: Otto Isaac
  • Patent number: 3956491
    Abstract: The main sapogenin of the roots and rhizomes of Helleborus species is used in medicine, especially to treat ulcers.
    Type: Grant
    Filed: April 7, 1975
    Date of Patent: May 11, 1976
    Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals Roessler
    Inventor: Otto Isaac
  • Patent number: 3932533
    Abstract: .alpha.- Bisabolol of plant origin is purified by being treated with alkali hydroxide, alkali alcoholate, alkali carbonate, alkali bicarbonate, alkaline earth hydroxide, alkaline earth oxide or aluminium hydroxide. Preferably activated carbon is also used in the purification. Preferably the .alpha.-bisabolol is treated with pure nitrogen gas before the alkali treatment.
    Type: Grant
    Filed: April 8, 1974
    Date of Patent: January 13, 1976
    Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals Roessler
    Inventors: Otto Isaac, Heribert Offermanns