Patents by Inventor Otto Roos

Otto Roos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 6465483
    Abstract: A compound of formula I wherein A denotes a benzo, indolo or thieno group; R1 denotes thienyl or the group  wherein R7, R8 and R9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of the substituents can simultaneously represent phenyl or benzyl; R2, m, R3 and R4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: October 15, 2002
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter Lösel, Otto Roos, Dietrich Arndts
  • Benzoylguanidine derivatives
    Patent number: 6323207
    Abstract: Novel benzoylguanidine derivatives of general formula I useful for the treatment or reduction of tissue damage due to ischaemia.
    Type: Grant
    Filed: September 15, 1999
    Date of Patent: November 27, 2001
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Christian Eickmeier, Erich Buerger, Stefan Matthias Blech, Otto Roos
  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 6180645
    Abstract: A compound of formula I wherein A denotes a benzo, indolo or thieno group; R1 denotes thienyl or the group wherein R7, R8 and R9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of the substituents can simultaneously represent phenyl or benzyl; R2, m, R3 and R4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: January 30, 2001
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter Lösel, Otto Roos, Dietrich Arndts
  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 6136819
    Abstract: Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --O--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1 -.sub.6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4 -.sub.7)cycloalkyl, (C.sub.4 -.sub.6)cycloalkyl(C.sub.1 -.sub.5)alkyl or ##STR2## wherein R is (C.sub.1 -.sub.4)alkyl, hydroxy, --N.sub.3, halogen (F, Cl, Br, I), CF.sub.3 or (C.sub.1 -.sub.4)alkoxy,u is 0, 1, 2 or 3, andm, R.sup.2, R.sup.4, R.sup.7, R.sup.8 and R.sup.9 are as defined in the specification, as well as pharmaceutical preparations containing these compounds and the pharmaceutical use thereof.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: October 24, 2000
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Otto Roos, Walter Losel, Dietrich Arndts
  • Benzoylguanidine derivatives, process for their preparation their use in the preparation of medicines
    Patent number: 6114335
    Abstract: The present invention relates to novel benzoylguanidine derivatives, processes for preparing them and their use in the preparation of pharmaceutical compositions.The novel benzoylguanidine derivatives correspond to general formula (I) ##STR1## which benzoylguanidine derivatives are useful in the treatment of ischemia.
    Type: Grant
    Filed: September 25, 1998
    Date of Patent: September 5, 2000
    Assignee: Boehringer Ingelheim KG
    Inventors: Erich Buerger, Christian Eickmeier, Otto Roos
  • Pharmaceutically useful 3,4-dihydroisoquinoline
    Patent number: 6034094
    Abstract: The invention relates to the use of carbocyclically and heterocycally fused dihydroyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhabiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 7, 2000
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts, Franz Josef Kuhn, Ilse Strelle
  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 5968948
    Abstract: Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --O--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1-6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4-7)cycloalkyl, (C.sub.4-6)cycloalkyl(C.sub.1-5)alkyl or ##STR2## wherein R is (C.sub.1-4)alkyl, hydroxy, --N.sub.3, halogen (F, Cl, Br, I), CF.sub.3 or (C.sub.1-4)alkoxy,u is 0, 1, 2 or 3, andm, R.sup.2, R.sup.4, R.sup.7, R.sup.8 and R.sup.9 are as defined in the specification, as well as pharmaceutical preparations containing these compounds and the pharmaceutical use thereof.
    Type: Grant
    Filed: May 16, 1997
    Date of Patent: October 19, 1999
    Assignee: Boerhinger Ingelheim GmbH
    Inventors: Otto Roos, Walter Losel, Dietrich Arndts
  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 5925650
    Abstract: A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, whilst not more than 2 of the substituents can simultaneously represent phenyl or benzyl;R.sup.2, m, R.sup.3 and R.sup.4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: July 20, 1999
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts
  • Dihydro-isoquinoline compounds and their use as pharmaceuticals
    Patent number: 5861412
    Abstract: Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: June 10, 1997
    Date of Patent: January 19, 1999
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos
  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 5837712
    Abstract: A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of the substituents can simultaneously represent phenyl or benzyl;R.sup.2, m, R.sup.3 and R.sup.4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 17, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts
  • Benzoyl guanidine derivatives, the preparation thereof and their use in pharmaceutical compositions
    Patent number: 5783576
    Abstract: New compounds of general formula (I) are provided: ##STR1## which are explained in the specification can be prepared by a variety of methods. The compounds may be used in pharmaceutical compositions.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: July 21, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Otto Roos, Georg Speck, Walter Losel, Dietrich Arndts, Wolf-Dietrich Bechtel
  • Pyridazino?4',5':3,4!pyrrolo-?2,1-a!-isoquinolines and the use thereof for preparing pharmaceutical preparations
    Patent number: 5688793
    Abstract: The invention relates to new pyridazino?4',5':3,4!-pyrrolo?2,1-a!isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids and complex-forming agents, wherein X is O, S or NHO and R.sub.1, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are defined as in the specification, and pharmaceutical preparations containing these compounds.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: November 18, 1997
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts
  • Anti-inflammatory method
    Patent number: 5686462
    Abstract: The invention relates to the use of carbocyclically and heterocyclically fused dihydropyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhibiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: November 11, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts, Franz Josef Kuhn, Ilse Strelle
  • 9-amino-pyridazino?4'5':3,4!pyrrolo-?2,1-a!isoquinolines and the use thereof for the production of pharmaceutical preparations
    Patent number: 5677304
    Abstract: The invention relates to the use of 9-amino-pyridazino-?4',5':3,4!pyrrolo?2,1-a!isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids, bases and complexing agents for preparing agents for treating chronic inflammatory processes, ulcerative colitis and Crohn's disease, and for producing agents having an antiproliferative activity. The definitions of substituents R.sub.1 to R.sub.9 are given in the specification. The invention also relates to new compounds of general formula I which are also defined in the specification and their use as cerebroprotective agents.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: October 14, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos
  • Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparations
    Patent number: 5674878
    Abstract: Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 7, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos
  • Cerebroprojection method
    Patent number: 5665729
    Abstract: The invention relates to the use of carbocyclically and heterocyclically fused dihydropyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhibiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: September 9, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts, Franz Josef Kuhn, Ilse Strelle
  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 5661157
    Abstract: Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --0--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1-6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4-7)cycloalkyl, (C.sub.4-6)cycloalkyl(C.sub.1-5)alkyl or ##STR2## wherein R is (C.sub.1-4)alkyl, hydroxy, --N.sub.3, halogen (F, Cl, Br, I), CF.sub.3 or (C.sub.1-4)alkoxy,u is 0, 1, 2 or 3, andm, R.sup.2, R.sup.4, R.sup.7, R.sup.8 and R.sup.9 are as defined in the specification, as well as pharmaceutical preparations containing these compounds and the pharmaceutical use thereof.
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: August 26, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Otto Roos, Walter Losel, Dietrich Arndts
  • Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparation
    Patent number: 5643919
    Abstract: Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 1, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos
  • 12-aminopyridazinopyrroloisoquinoline compounds
    Patent number: 5614516
    Abstract: The invention relates to new 12-amino-pyridazino-[4',5':3,4]-pyrrolo[2,1-a]isoquinolines of general formula (I) ##STR1## wherein --NR.sub.1 R.sub.2 represents an amino or substituted amino group, and acid addition salts thereof. The new active substances have potential use in pharmaceutical compositions for treating cardiac insufficiency and cerebral metabolic disorders.
    Type: Grant
    Filed: February 7, 1995
    Date of Patent: March 25, 1997
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter L osel, Otto Roos, Gerd Schorrenberg, Helmut Ensinger, Richard Reichl
  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 5607943
    Abstract: A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## whereinR.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, whilst not more than 2 of the substituents can simultaneously represent phenyl or benzyl;R.sup.2, m, R.sup.3 and R.sup.4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: March 4, 1997
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter L osel, Otto Roos, Dietrich Arndts