Abstract: An application of omega-3 and/or omega-6 fatty acid(s) for the therapeutic treatment of the human or animal body in the case of an impaired sphingolipid metabolism, in particular in the case of impaired sphingolipid synthesis and/or excessive sphingolipid degradation. The agent is applied in the case of missing, reduced and/or defective formation of a sphingomyelin synthase enzyme in the body, in particular the enzyme sphingomyelin synthase 1 or the enzyme sphingomyelin synthase 2. The application has proved to be useful in the case of a defect of the sphingomyelin synthase 1 gene or of the sphingomyelin synthase 2 gene. The omega-3 and/or omega-6 fatty acid(s) preferably comprise(s) polyunsaturated omega-3 and/or omega-6 fatty acid(s), preferably EPA, DHA, DPA, ETA, 21:5n3 and/or SDA. A method for determining a cause of a disease in an animal or a human being and a device for carrying out the method are also provided.

Abstract: An application of omega-3 and/or omega-6 fatty acid(s) for the therapeutic treatment of the human or animal body in the case of an impaired sphingolipid metabolism, in particular in the case of impaired sphingolipid synthesis and/or excessive sphingolipid degradation. The agent is applied in the case of missing, reduced and/or defective formation of a sphingomyelin synthase enzyme in the body, in particular the enzyme sphingomyelin synthase 1 or the enzyme sphingomyelin synthase 2. The application has proved to be useful in the case of a defect of the sphingomyelin synthase 1 gene or of the sphingomyelin synthase 2 gene. The omega-3 and/or omega-6 fatty acid(s) preferably comprise(s) polyunsaturated omega-3 and/or omega-6 fatty acid(s), preferably EPA, DHA, DPA, ETA, 21:5n3 and/or SDA. A method for determining a cause of a disease in an animal or a human being and a device for carrying out the method are also provided.

Abstract: The invention describes a manufacturing device (1) and a method for bending blanks (4) or workpieces (5), having a bending press (2) and having a manipulator (3), which can be displaced in a raceway parallel to a longitudinal extent of a table and bending beam (10, 14), for workpiece transfer between a feeding or removal apparatus for the blanks (4) or the workpieces (5) and a forming region between bending tools (21). The manipulator (3) has an articulated-arm arrangement (33) having preferably three arms (34, 35, 36) which can be pivoted via pivoting bearing arrangements (37) about pivot axes (39) which are oriented parallel to the raceway, and said manipulator has a rotary unit (41), having a rotational axis (42) which extends perpendicularly with respect to the pivot axes (39), at one distal end of the articulated-arm arrangement (33).

Abstract: The invention describes a manufacturing device (1) and a method for bending blanks (4) or workpieces (5), having a bending press (2) and having a manipulator (3), which can be displaced in a raceway parallel to a longitudinal extent of a table and bending beam (10, 14), for workpiece transfer between a feeding or removal apparatus for the blanks (4) or the workpieces (5) and a forming region between bending tools (21). The manipulator (3) has an articulated-arm arrangement (33) having preferably three arms (34, 35, 36) which can be pivoted via pivoting bearing arrangements (37) about pivot axes (39) which are oriented parallel to the raceway, and said manipulator has a rotary unit (41), having a rotational axis (42) which extends perpendicularly with respect to the pivot axes (39), at one distal end of the articulated-arm arrangement (33).

Abstract: A wear liner is provided for the roof of the pedestal jaw of a side frame. The liner is welded in place only along the lateral edges of the liner and is retained in place, in the event of weld failure, by depending legs engageable with pedestal jaw stop lugs. Additional retaining lugs may be provided in the pedestal jaw roof.

Abstract: A wear liner is provided for the roof of the pedestal jaw of a side frame. The liner is welded in place only along the lateral edges of the liner and is retained in place, in the event of weld failure, by depending legs engageable with pedestal jaw stop lugs. Additional retaining lugs may be provided in the pedestal jaw roof.