Patents by Inventor Otto Westphal

Otto Westphal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions comprising fetal hemoglobin and bacterial endotoxin and optionally additional fetal liver components
    Patent number: 7968103
    Abstract: The present invention relates to a pharmaceutical composition representing a novel immunomodulating principle comprising bacterial endotoxin, fetal hemoglobin or more particularly a heme-free derivative or the ?-chain thereof, and optionally, components which are present in the fetal liver in addition to HbF. The composition is delivered to humans in a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that endotoxin and fetal hemoglobin partial structures display a pronounced synergistic biomedical activity. The biomedical effect of fetal hemoglobin and its partial structures is surprisingly not based on a classical hemoglobin function as an oxygen transporter but related to a modulation of endotoxin-mediated bioactivity. This biomedical activity is surprisingly also observed after oral application of the composition.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: June 28, 2011
    Inventors: Otto Westphal, Josette Westphal, legal representative, Alexander Westphal, legal representative, Thierry Walli, Reginald Gorczynski, Silke Muller, Jean-Pierre Mach, Alfred Hartman, Wolfgang Bessler, Petra Hofmann, Ulrich Zahringer, Christian Alexander, Ulrich vor dem Esche, Artur J. Ulmer, Antonio Verdini
  • Compositions Comprising Fetal Hemoglobin and Bacterial Endotoxin and Optionally Additional Fetal Liver Components
    Publication number: 20080075742
    Abstract: The present invention relates to a pharmaceutical composition representing a novel immunomodulating principle comprising bacterial endotoxin, fetal hemoglobin or more particularly a heme-free derivative or the ?-chain thereof, and optionally, components which are present in the fetal liver in addition to HbF. The composition is delivered to humans in a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that endotoxin and fetal hemoglobin partial structures display a pronounced synergistic biomedical activity. The biomedical effect of fetal hemoglobin and its partial structures is surprisingly not based on a classical hemoglobin function as an oxygen transporter but related to a modulation of endotoxin-mediated bioactivity. This biomedical activity is surprisingly also observed after oral application of the composition.
    Type: Application
    Filed: February 18, 2004
    Publication date: March 27, 2008
    Inventors: Otto Westphal, Josette Mottier Westphal, Alexander Westphal, Thierry Walli, Reginald Gorczynski, Silke Muller, Jean-Pierre Mach, Alfred Hartman, Wolfgang Bessler, Petra Hofmann, Ulrich Zahringer, Christian Alexander, Ulrich vor dem Esche, Artur J. Ulmer, Antonio Verdini
  • Injection needle arrangement
    Patent number: 5417662
    Abstract: A device for limiting the penetration of an injection needle when an injection is administered from an injection apparatus comprises an exterior sleeve (1) arranged around the front part of the injection apparatus (2). In its foremost position, the sleeve (1) surrounds the needle (8) completely, and it may be displaced rearwards while overcoming a spring force (6), to expose the needle (8).
    Type: Grant
    Filed: May 3, 1993
    Date of Patent: May 23, 1995
    Assignee: Pharmacia AB
    Inventors: Birger Hjertman, Otto Westphal
  • Glycerin-alkylether-(1)-phosphoric acid-(3)-monocholine esters as enhancers of the natural resistance of the mammalian organism against non-carcinogenic pathogens
    Patent number: 4119714
    Abstract: Pharmaceutical compositions comprising as the active ingredient an ether-olecithin of the formula ##STR1## wherein R is alkyl of at least 12 and preferably 18 carbon atoms; the compositions are useful for enhancing the natural resistance of the mammalian organism against non-carcinogenic pathogens.
    Type: Grant
    Filed: January 26, 1977
    Date of Patent: October 10, 1978
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e. V.
    Inventors: Gunter Kny, Otto Westphal
  • Lipid A-preparation
    Patent number: 4029762
    Abstract: A preparation consisting essentially of lipid A or alkali-treated lipid A sorbed on a particulate organic carrier material and an immunizing agent containing same being useful against diseases caused by gram-negative enterobacteriaceae.
    Type: Grant
    Filed: December 22, 1975
    Date of Patent: June 14, 1977
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventors: Chris Galanos, Otto Luderitz, Otto Westphal