Patents by Inventor Otto-Wilhelm Merten

Otto-Wilhelm Merten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for removing anti-AAV antibodies from a blood-derived composition
    Patent number: 11376321
    Abstract: The present invention relates to a method for removing undesired anti-AAV antibodies from a blood-derived composition.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: July 5, 2022
    Assignees: GENETHON, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), SORBONNE UNIVERSITÉ, ASSOCIATION INSTITUT DE MYOLOGIE
    Inventors: Bérangére Bertin, Carole Masurier, Otto-Wilhelm Merten, Federico Mingozzi
  • Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
    Patent number: 11236307
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: February 1, 2022
    Assignee: GENETHON
    Inventors: Otto-Wilhelm Merten, Martin Marek, Monique Van Oers
  • FLUID SYSTEM FOR PRODUCING EXTRACELLULAR VESICLES AND ASSOCIATED METHOD
    Publication number: 20200385665
    Abstract: A fluidic system for producing extracellular vesicles from producer cells, including at least one container, a liquid medium contained by the container and producer cells, characterised in that it also includes microcarriers suspended in the liquid medium, the majority of producer cells being adherent to the surface of the microcarriers, and a liquid medium agitator, the agitator and the dimensions of the container being adapted to control a turbulent flow of the liquid medium in the container.
    Type: Application
    Filed: June 29, 2018
    Publication date: December 10, 2020
    Applicants: UNIVERSITE PARIS DIDEROT PARIS 7, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), GENETHON
    Inventors: Florence GAZEAU, Amanda Karine Andriola SILVA, Otto-Wilhelm MERTEN, Claire WILHELM, Max PIFFOUX
  • Baculovirus system for the expression of a gene therapy vector
    Patent number: 10767192
    Abstract: The invention relates to a recombinant baculoviral genome useful for the production of viral vectors for gene therapy, allowing said production from a single infection.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: September 8, 2020
    Assignee: GENETHON
    Inventors: Lionel Galibert, Otto-Wilhelm Merten, Aurelien Jacob
  • METHOD FOR REMOVING ANTI-AAV ANTIBODIES FROM A BLOOD-DERIVED COMPOSITION
    Publication number: 20200069790
    Abstract: The present invention relates to a method for removing undesired anti-AAV antibodies from a blood-derived composition.
    Type: Application
    Filed: March 1, 2018
    Publication date: March 5, 2020
    Inventors: BÉRANGÉRE BERTIN, CAROLE MASURIER, OTTO-WILHELM MERTEN, FEDERICO MINGOZZI
  • BACULOVIRUS-BASED PRODUCTION OF BIOPHARMACEUTICALS FREE OF CONTAMINATING BACULOVIRAL VIRIONS
    Publication number: 20200002683
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.
    Type: Application
    Filed: August 27, 2019
    Publication date: January 2, 2020
    Inventors: OTTO-WILHELM MERTEN, MARTIN MAREK, MONIQUE VAN OERS
  • Baculovirus expression systems
    Patent number: 10480010
    Abstract: The present invention relates to an optimized baculovirus construct useful for the production of virus(-like) particles or viral vectors, in particular viral vectors for gene therapy.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: November 19, 2019
    Assignee: GENETHON
    Inventors: Lionel Galibert, Otto-Wilhelm Merten, Monique Van Oers, Christel Riviere
  • Method for purifying enveloped viruses or viral vectors
    Patent number: 10465169
    Abstract: The invention relates to a process for purifying enveloped viruses. The process of the invention is useful for recovering at a large scale enveloped viruses under conditions complying with good manufacturing practices and allowing viruses of a clinical grade to be obtained.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: November 5, 2019
    Assignee: GENETHON
    Inventors: Driss Boudeffa, Otto-Wilhelm Merten, David Fenard
  • Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
    Patent number: 10428315
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: October 1, 2019
    Assignee: GENETHON
    Inventors: Otto-Wilhelm Merten, Martin Marek, Monique Van Oers
  • BACULOVIRUS SYSTEM FOR THE EXPRESSION OF A GENE THERAPY VECTOR
    Publication number: 20180305717
    Abstract: The invention relates to a recombinant baculoviral genome useful for the production of viral vectors for gene therapy, allowing said production from a single infection
    Type: Application
    Filed: July 9, 2018
    Publication date: October 25, 2018
    Inventors: LIONEL GALIBERT, OTTO-WILHELM MERTEN, AURELIEN JACOB
  • Baculovirus system for the expression of a gene therapy vector
    Patent number: 10017783
    Abstract: The invention relates to a recombinant baculoviral genome useful for the production of viral vectors for gene therapy, allowing said production from a single infection.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: July 10, 2018
    Assignee: GENETHON
    Inventors: Lionel Galibert, Otto-Wilhelm Merten, Aurélien Jacob
  • BACULOVIRUS-BASED PRODUCTION OF BIOPHARMACEUTICALS FREE OF CONTAMINATING BACULOVIRAL VIRIONS
    Publication number: 20180127728
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.
    Type: Application
    Filed: December 14, 2017
    Publication date: May 10, 2018
    Inventors: OTTO-WILHELM MERTEN, MARTIN MAREK, MONIQUE VAN OERS
  • Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
    Patent number: 9862934
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: January 9, 2018
    Assignee: GENETHON
    Inventors: Otto-Wilhelm Merten, Martin Marek, Monique Van Oers
  • METHOD FOR PURIFYING ENVELOPED VIRUSES OR VIRAL VECTORS
    Publication number: 20170002332
    Abstract: The invention relates to a process for purifying enveloped viruses. The process of the invention is useful for recovering at a large scale enveloped viruses under conditions complying with good manufacturing practices and allowing viruses of a clinical grade to be obtained.
    Type: Application
    Filed: December 17, 2014
    Publication date: January 5, 2017
    Inventors: DRISS BOUDEFFA, OTTO-WILHELM MERTEN, DAVID FENARD
  • BACULOVIRUS-BASED PRODUCTION OF BIOPHARMACEUTICALS FREE OF CONTAMINATING BACULOVIRAL VIRIONS
    Publication number: 20150252335
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.
    Type: Application
    Filed: March 27, 2015
    Publication date: September 10, 2015
    Inventors: OTTO-WILHELM MERTEN, MARTIN MAREK, MONIQUE VAN OERS
  • Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
    Patent number: 8993317
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with reduced or no contaminating baculoviral virions.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: March 31, 2015
    Assignee: Genethon
    Inventors: Otto-Wilhelm Merten, Martin Marek, Monique Van Oers
  • BACULOVIRUS EXPRESSION SYSTEMS
    Publication number: 20140356904
    Abstract: The present invention relates to an optimized baculovirus construct useful for the production of virus (-like) particles or viral vectors, in particular viral vectors for gene therapy.
    Type: Application
    Filed: July 27, 2012
    Publication date: December 4, 2014
    Applicant: Genethon
    Inventors: Lionel Galibert, Otto-Wilhelm Merten, Monique Van Oers, Christel Riviere
  • BACULOVIRUS SYSTEM FOR THE EXPRESSION OF A GENE THERAPY VECTOR
    Publication number: 20140349374
    Abstract: The invention concerns a recombinant baculovirus genome useful for the expression of gene therapy vectors by means of a single infection.
    Type: Application
    Filed: July 27, 2012
    Publication date: November 27, 2014
    Applicant: Genethon
    Inventors: Lionel Galibert, Otto-Wilhelm Merten, Aurélien Jacob
  • BACULOVIRUS-BASED PRODUCTION OF BIOPHARMACEUTICALS FREE OF CONTAMINATING BACULOVIRAL VIRIONS
    Publication number: 20120149010
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with reduced or no contaminating baculoviral virions.
    Type: Application
    Filed: August 5, 2010
    Publication date: June 14, 2012
    Applicant: Genethon
    Inventors: Otto-Wilhelm Merten, Martin Marek, Monique Van Oers