Patents by Inventor Otto Wolfbeis

Otto Wolfbeis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100020846
    Abstract: The invention provides a temperature-threshold indicator device 10 comprising a sealed housing 12 having at least one surface 14 which is transparent and containing a suspension of inorganic nanoparticles 18 suspended in a liquid medium wherein the suspension undergoes an irreversible detectible change in optical characteristics upon freezing of the liquid medium due to aggregation of the nanoparticles, and wherein the device is provided a with means for association thereof with a product whereby the temperature-threshold indicator device 10 serves to determine whether the product has been exposed to an environment of predetermined coldness.
    Type: Application
    Filed: June 14, 2007
    Publication date: January 28, 2010
    Inventors: Michael Kagan, Vladimir Mirsky, Otto Wolfbeis
  • Publication number: 20070184559
    Abstract: Hence the invention concerns a method which can be used to provide a fluorescent label on bioorganic molecules carrying amino groups such as amino acids, proteins, pharmaceutical agents, antibodies, amino group-modified nucleotides and also polymers and polymer particles carrying amino groups by means of a chemical (covalent) binding. The method is based on the reaction of a pyrylium salt located on a fluorophore F with the amino group of a biomolecule or particle according to the described reaction equation. The method is selective, simple to carry out and results in high labelling yields. The spectral properties of the conjugates differ considerably from those of the starting compounds and their fluorescence quantum yields are often considerably increased.
    Type: Application
    Filed: December 15, 2006
    Publication date: August 9, 2007
    Inventors: Sergey Yarmoluk, Olexandr Kostenko, Oleksiy Tolmachev, Otto Wolfbeis
  • Patent number: 7052864
    Abstract: The present invention concerns biological methods of determination using enzymes from the group of oxidases and using optical indicators from the group of lanthanoid-ligand complexes.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: May 30, 2006
    Assignee: Active Motif Chromeon GmbH
    Inventors: Axel Durkop, Otto Wolfbeis
  • Publication number: 20060081032
    Abstract: A method and a sensor for determining acidic gases in gas mixtures, such as hydrogen chloride, sulfur dioxide, or nitrogen dioxide. A polymer layer whose electrical conductance changes under the effect of the gas to be determined is exposed to the gas mixture, and the electrical conductance, the electrical resistance, or the impedance of the polymer layer is determined. For the desorption of the gas to be determined, the polymer layer is heated at certain time intervals to a temperature above ambient temperature.
    Type: Application
    Filed: September 29, 2005
    Publication date: April 20, 2006
    Inventors: Thomas Brinz, Vladimir Mirsky, Otto Wolfbeis, Jorg Jockel, Qingli Hao
  • Patent number: 4965087
    Abstract: A sensor element useful in making fluorescence-optical measurements includes a substrate having a carrier surface, particles having a large specific surface are which are glued, melted or sintered onto the carrier surface so as to provide small elevations of a regular distribution on the carrier surface, and an indicator substance immobilized on the particles. Additional substances can be applied to the particles to reduce undesirable influences of properties of the sample on the indicator substance.
    Type: Grant
    Filed: March 23, 1988
    Date of Patent: October 23, 1990
    Assignee: AVL AG
    Inventors: Otto Wolfbeis, Herbert Kroneis, Helmut Offenbacher
  • Patent number: 4657736
    Abstract: In an O.sub.2 sensor element which contains a fluorescent indicator substance, a polymerized silicone polymer is used as a carrier material in which the indicator substance is incorporated in solubilized form and in an at least approximately homogeneous distribution. Solubilization of the indicator substance may essentially be performed in analogy to Friedel-Crafts alkylation of aromatics, which will increase solubility of the indicator substance in the polymer carrier without affecting quenching behavior.
    Type: Grant
    Filed: July 14, 1986
    Date of Patent: April 14, 1987
    Assignee: AVL AG
    Inventors: Hermann Marsoner, Herbert Kroneis, Otto Wolfbeis
  • Patent number: 4568518
    Abstract: Fluorescence-optical indicator material is chemically bonded in a network structure permeating a carrier membrane of the sensor element. As this network structure is independent of the membrane and not chemically bonded thereto, the properties of the membrane and the indicator are not affected by the immobilization.
    Type: Grant
    Filed: December 2, 1983
    Date of Patent: February 4, 1986
    Assignee: AVL AG
    Inventors: Otto Wolfbeis, Herbert Kroneis, Helmut Offenbacher
  • Patent number: 4154741
    Abstract: A new process for the manufacture of pyrono-condensed coumarin compounds by reacting an anil derivative of a heterocyclic compound with a cyanoacetic acid derivative in the presence of a base and a strong polar aprotic solvent is described.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: May 15, 1979
    Assignee: Ciba-Geigy Corporation
    Inventors: Erich Ziegler, Otto Wolfbeis