Patents by Inventor Ottorino De Lucchi

Ottorino De Lucchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Efficient process for the preparation of sitagliptin
    Patent number: 11174266
    Abstract: Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: November 16, 2021
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Terry Shi, Sam Lou, Ottorino De Lucchi, Pierluigi Padovan
  • NEW EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN
    Publication number: 20210061808
    Abstract: Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.
    Type: Application
    Filed: January 11, 2019
    Publication date: March 4, 2021
    Applicant: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Terry SHI, Sam LOU, Ottorino DE LUCCHI, Pierluigi PADOVAN
  • Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid
    Patent number: 10913747
    Abstract: Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: February 9, 2021
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Ottorino De Lucchi, Pierluigi Padovan, Elena Brasola
  • EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID
    Publication number: 20200157109
    Abstract: Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.
    Type: Application
    Filed: May 15, 2018
    Publication date: May 21, 2020
    Applicant: F.I.S. - FABBRiCA ITALIANA SINTETICI S.P.A.
    Inventors: Ottorino DE LUCCHI, Pierluigi PADOVAN, Elena BRASOLA
  • Convenient process for the preparation of statins
    Patent number: 9932361
    Abstract: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: April 3, 2018
    Inventors: Ottorino De Lucchi, Stefano Tartaggia, Clark Ferrari, Marco Galvagni, Marta Pontini, Stefano Fogal, Riccardo Motterle, Rosa Maria Moreno, Alex Comely
  • Photocrosslinked hyaluronic acid derivatives, and the preparation process and use thereof
    Patent number: 9889226
    Abstract: Disclosed are photocrosslinked hyaluronic acid (HA) derivatives consisting of HA, a bifunctional polyethylene glycol (PEG) spacer which is triethylene glycol, and a photoreactive compound selected from a coumarin derivative and propiophenone.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: February 13, 2018
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Monica Campisi, Ottorino De Lucchi, Riccardo Beninatto, Giuseppe Borsato
  • Process for the preparation of eslicarbazepine and eslicarbazepine acetate
    Patent number: 9845293
    Abstract: Object of the present invention is an improved process for the preparation of Elsicarbazepine and Eslicarbazepine acetate by means of chiral Ruthenium catalysts.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: December 19, 2017
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Simone Zaramella, Emiliano Rossi, Ottorino De Lucchi, Siro Serafini
  • PROCESS FOR THE PREPARATION OF ESLICARBAZEPINE AND ESLICARBAZEPINE ACETATE
    Publication number: 20170305860
    Abstract: An improved process for the preparation of Elsicarbazepine and Eslicarbazepine acetate by means of chiral Ruthenium catalysts is provided.
    Type: Application
    Filed: February 23, 2016
    Publication date: October 26, 2017
    Inventors: Simone ZARAMELLA, Emiliano ROSSI, Ottorino DE LUCCHI, Siro SERAFINI
  • Process for the preparation of key intermediates of omarigliptin
    Patent number: 9481680
    Abstract: An improved process for the preparation of a key intermediate for the synthesis of the active ingredient Omarigliptin is provided. The key intermediate is a compound having the following formula (I) wherein R1 is propargyl or allyl group and P is an amine protecting group. The compound of formula (I) is prepared by converting a compound of formula (IV) by an amination reaction to a compound of formula (III), which is then protected to provide a compound of formula (II), which is then alkylated to provide the compound of formula (I).
    Type: Grant
    Filed: January 19, 2015
    Date of Patent: November 1, 2016
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A
    Inventors: Ottorino De Lucchi, Enrico Rosso, Simone Zaramella, Stefano Tartaggia
  • CONVENIENT PROCESS FOR THE PREPARATION OF STATINS
    Publication number: 20160200744
    Abstract: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
    Type: Application
    Filed: March 8, 2016
    Publication date: July 14, 2016
    Inventors: Ottorino DE LUCCHI, Stefano TARTAGGIA, Clark FERRARI, Marco GALVAGNI, Marta PONTINI, Stefano FOGAL, Riccardo MOTTERLE, Rosa Maria MORENO, Alex COMELY
  • PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES OF OMARIGLIPTIN
    Publication number: 20160200727
    Abstract: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of the active pharmaceutical ingredient named Omarigliptin.
    Type: Application
    Filed: January 19, 2015
    Publication date: July 14, 2016
    Inventors: Ottorino DE LUCCHI, Enrico ROSSO, Simone ZARAMELLA, Stefano TARTAGGIA
  • Convenient process for the preparation of statins
    Patent number: 9315470
    Abstract: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: April 19, 2016
    Assignee: F.I.S.—Fabbrica Italiana Sintetiei S.p.A.
    Inventors: Ottorino De Lucchi, Stefano Tartaggia, Clark Ferrari, Marco Galvagni, Marta Pontini, Stefano Fogal, Riccardo Motterle, Rosa Maria Moreno, Alex Comely
  • Intermediate compounds and derivatives thereof involved in the preparation of 2,4,5-trifluorophenylacetic acid compounds and derivatives thereof
    Patent number: 9238613
    Abstract: Described herein are intermediate compounds and derivatives thereof that can be synthesized during the preparation of 2,4,5-trifluorophenylacetic acid and derivatives thereof.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: January 19, 2016
    Assignee: F.I.S.—Fabrica Italiana Sintetici S.p.A.
    Inventors: Stefano Tartaggia, Andrea Caporale, Ottorino De Lucchi
  • PHOTOCROSSLINKED HYALURONIC ACID DERIVATIVES, AND THE PREPARATION PROCESS AND USE THEREOF
    Publication number: 20150367027
    Abstract: Disclosed are photocrosslinked hyaluronic acid (HA) derivatives consisting of HA, a bifunctional polyethylene glycol (PEG) spacer which is triethylene glycol, and a photoreactive compound selected from a coumarin derivative and propiophenone.
    Type: Application
    Filed: February 4, 2014
    Publication date: December 24, 2015
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Monica CAMPISI, Ottorino DE LUCCHI, Riccardo BENINATTO, Giuseppe BORSATO
  • Convenient Process for the Preparation of Statins
    Publication number: 20150344439
    Abstract: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
    Type: Application
    Filed: February 11, 2014
    Publication date: December 3, 2015
    Inventors: Ottorino DE LUCCHI, Stefano TARTAGGIA, Clark FERRARI, Marco GALVAGNI, Marta PONTINI, Stefano FOGAL, Riccardo MOTTERLE, Rosa Maria MORENO, Alex COMELY
  • NEW PROCESS FOR THE PREPARATION OF 2,4,5-TRIFLUOROPHENYLACETIC ACID
    Publication number: 20140350287
    Abstract: The present invention relates to a new process for the preparation of 2,4,5-trifluorophenylacetic acid and salts thereof by means of new synthetic intermediates.
    Type: Application
    Filed: August 12, 2014
    Publication date: November 27, 2014
    Inventors: Stefano Tartaggia, Andrea Caporale, Ottorino De Lucchi
  • Process for the preparation of 2,4,5-trifluorophenylacetic acid
    Patent number: 8835679
    Abstract: The present invention relates to a new process for the preparation of 2,4,5-trifluorophenylacetic acid and salts thereof by new synthetic intermediates.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: September 16, 2014
    Assignee: F.I.S.—Fabrica Italiana Sintetici S.p.A.
    Inventors: Stefano Tartaggia, Andrea Caporale, Ottorino De Lucchi
  • Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib
    Patent number: 8664402
    Abstract: A process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methyl sulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. The synthesis of the intermediates useful for such preparation is also described.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: March 4, 2014
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Andrea Castellin, Paolo Stabile, Francesco Fontana, Ottorino De Lucchi, Andrea Caporale, Stefano Tartaggia
  • Method for the preparation of erlotinib
    Patent number: 8609841
    Abstract: An alternative method for the preparation of Erlotinib through a new chemical reaction for the preparation of the 4-(3-aminophenyl)-2-methyl-3-butyn-2-ol key intermediate of formula (IV) according to the following scheme.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: December 17, 2013
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Andrea Castellin, Ottorino De Lucchi, Andrea Caporale
  • Process for the preparation of brinzolamide
    Patent number: 8344136
    Abstract: The present invention relates to a process for the preparation of Brinzolamide, or 2H-thieno[3,2-e]-1,2-thiazin-6-sulfonamide, 4-(ethyl amino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (4R)-via intermediates 2,3-dihydro-4H-thieno[3,2-e]-1,2-thiazin-4-ones, 1,1-dioxide. Further objects of the present invention are the intermediates mentioned above and other intermediates of the synthesis.
    Type: Grant
    Filed: June 15, 2009
    Date of Patent: January 1, 2013
    Assignee: PHF S.A.
    Inventors: Alessandro Falchi, Ottorino De Lucchi, Andrea Castellin