Abstract: Crystallization of an organic pharmaceutical compound is achieved by atomization of one solution and introduction of the atomized solution into a vessel containing a second solution where the solutions are mixed to form a product. The process can be performed on non-reactive constituents such as a solution containing the compound to be crystallized dissolved in a solvent and an anti-solvent solution. Alternatively, the process can be performed on reactive constituents, such as solutions of solvents containing different reactive intermediates, under proper reactive conditions. The process may be practiced continuously or in batch mode. Atomizers of the non-pressure-driven ultrasonic type or of the ultrasonic or non-ultrasonic pressure-driven type can be utilized.

Abstract: A first solution and a second solution are supplied to the inlet conduit of a chamber. The chamber includes a stator formed of spaced stationery blades within which a rotor with spaced blades is rotatably received. As the rotor is rotated, high shear mixing forces are applied to the solutions and crystallization take place within the chamber. Additional mixing of the product can take place after it leaves the chamber. Seed material can be introduced to the chamber and recirculated from the inlet to the outlet as the process is performed. The process can be used to combine a solution of the material to be crystallized dissolved in a solvent and an anti-solvent solution. Alternatively, solutions containing first and second reactive intermediates in solvents can be combined under conditions of temperature and pressure that permit reaction of the first and second reactive intermediates to produce a reaction product of limited solubility in the solvent mixture.