Abstract: The present invention relates to a nucleic acid molecule capable of blocking motor protein, a library containing the nucleic acid molecule, a method for constructing the nucleic acid molecule or library containing the same, and an application of the nucleic acid molecule or library containing same.

Abstract: The present invention provides a helicase BCH2X, comprising an amino acid sequence represented by any one of SEQ ID NOs: 1-3. The present invention also provides a complex structure comprising the helicase BCH2X and a binding moiety for binding polynucleotides. The present invention also provides a use of the helicase BCH2X or the complex structure comprising same in the control and characterization of polynucleotides and single-molecule nanopore sequencing.

Abstract: Provided is helicase BCH1X, which comprises an amino acid sequence represented by SEQ ID NO: 1 or 2. Further provided are a complex structure comprising helicase BCH1X and a binding moiety used for binding to a polynucleotide, and a use thereof in the control and characterization of a polynucleotide and in single molecule nanopore sequencing.

Abstract: The present invention provides methods, compositions (e.g., eyedrop or spongarion composition), and uses for alleviating and preventing age-associated vitreous degeneration in a mammal, comprising administrating to the mammal in need thereof a therapeutically effective amount of L-ergothioneine, an analog or derivative thereof, or a pharmaceutically acceptable salt, acid, ester, polymer, analog or derivative thereof, as an active ingredient. In particular, L-ergothioneine is capable of scavenging chronic reactive oxygen species directly and radically to mitigate and prevent HA depolymerization and HA decreasing-viscosity in the mammal's vitreous body; and/or improving vitreous liquefaction in the mammal.

Abstract: Described herein are high coverage single tube Long Fragment Read (stLFR) technology which uses performs stLFR on target DNA fragments that have already been amplified before they are co-barcoded, which provides higher amount of DNA for sequencing and increases sequencing coverage. In some embodiments, the high coverage stLFR described in this application uses two rounds of stLFR. In some embodiments, the target DNA fragments are transposed with transposons having particular positional barcodes that can be used to order sequence reads.

Abstract: The present invention provides methods, compositions (e.g., eyedrop or spongarion composition), and uses for alleviating and preventing age-associated vitreous degeneration in a mammal, comprising administrating to the mammal in need thereof a therapeutically effective amount of L-ergothioneine, an analog or derivative thereof, or a pharmaceutically acceptable salt, acid, ester, polymer, analog or derivative thereof, as an active ingredient. In particular, L-ergothioneine is capable of scavenging chronic reactive oxygen species directly and radically to mitigate and prevent HA depolymerization and HA decreasing-viscosity in the mammal's vitreous body; and/or improving vitreous liquefaction in the mammal.

Abstract: An electronic device includes: at least one connection interface, to receive an external signal. A first signal switching multiplexer is connected to the connection interface. A laptop system is connected to the first signal switching multiplexer, to operate in a laptop mode. A drawing board system is connected to the first signal switching multiplexer, to operate in a drawing board mode and an independent screen mode. A switching switch generates a switching signal and transmits it to the first signal switching multiplexer, the laptop system, and the drawing board system, to select the laptop mode, the drawing board mode, or the independent screen mode.

Abstract: Techniques for context sensitive overlays, comprising a social networking application. The social networking application may include, among other components, a social networking overlay management component to receive a request from a mobile device to determine a list of aggregate overlay information and user context information, and providing the list of aggregate overlay information and user context information to the mobile device, a context determination component to determine the user context information representative of at least one user context based at least partially on user profile information, location information, calendar event information, and/or external event information, and an overlay selection component to generate the list of aggregate overlay information based at least partially on the user profile information, overlay promotion information, and user context information.

Abstract: A touchpad device is provided in the disclosure. The touchpad device includes a touch circuit board, at least two pressure detecting elements, a touch control unit, and a pressure control unit. The touch circuit board includes a touchable zone. The at least two pressure detecting elements are located below the touch circuit board and correspond to at least one pressure sensitive input region in the touchable zone. The touch control unit is electrically connected to the touch circuit board and is configured to receive and process a touch signal from the touch circuit board to generate touch coordinate information. The pressure control unit is electrically connected to the pressure detecting elements and is configured to receive and process a pressure signal detected by the pressure detecting elements in the pressure sensitive input region to generate touch pressure information.

Abstract: Provided is a method for obtaining a double-stranded sequence by single-stranded rolling circle amplification, comprising: 1) performing rolling circle amplification reaction on single-stranded circular DNA by means of a first primer to obtain an amplified sequence, the first primer being complementary to a partial region of the single-stranded circular DNA, and the single-stranded circular DNA having a break mechanism that can cause the single-stranded circular DNA to ring-open; 2) ring-opening the single-stranded circular DNA by means of the break mechanism to obtain single-stranded linear DNA; and 3) using the single-stranded linear DNA as a second primer and using the amplified sequence obtained in step 1) as a template to perform amplification reaction to obtain an amplified double-stranded sequence.

Abstract: The disclosure provides an electronic device adapted to communicate with a stylus. The electronic device includes a display panel, a touch module, and a processor. The display panel has a display area, the touch module has a touchable area, and the processor is electrically connected to the display panel and the touch module. The processor is configured to: define at least one effective input area in response to an operation of the stylus in the touchable area, and when the touch module detects that the stylus is approaching the effective input area, switch the effective input area to a stylus mode, and display a range marking pattern in the effective input area.

Abstract: The present invention provides novel methods for preparing a moisture-proof amino acid material. The present invention also provides novel compositions or nutritional supplements comprising the moisture-proof amino acid materials prepared by the methods of this invention.

Abstract: The present invention provides methods, compositions (e.g., eyedrop or spongarion composition), and uses for alleviating and preventing age-associated vitreous degeneration in a mammal, comprising administrating to the mammal in need thereof a therapeutically effective amount of L-ergothioneine, an analog or derivative thereof, or a pharmaceutically acceptable salt, acid, ester, polymer, analog or derivative thereof, as an active ingredient. In particular, L-ergothioneine is capable of scavenging chronic reactive oxygen species directly and radically to mitigate and prevent HA depolymerization and HA decreasing-viscosity in the mammal's vitreous body; and/or improving vitreous liquefaction in the mammal.

Abstract: An electronic device and a knob module thereof are provided. The knob module includes a circuit board, a rotary encoder, a light guide structure, a plurality of light emitting units, and a rotation cover. The rotary encoder is disposed on the circuit board. The light guide structure is disposed on the circuit board. The light guide structure includes a light guide ring and an annular light guide wall. The light guide ring surrounds the rotary encoder. The annular light guide wall extends downward from the light guide ring to abut against the circuit board. The plurality of light emitting units is disposed on the circuit board and located between the annular light guide wall and the rotary encoder for emitting light toward the annular light guide wall. The rotation cover is disposed on the rotary encoder.

Abstract: A system for providing context sensitive display overlays to a mobile device via a network comprising an overlay datastore, a processor, coupled to the datastore and programmed to receive a request from a mobile device via the network for a list of overlays, determine user context information, search the datastore for overlays matching the user context and provide the list of overlays to the mobile device via the network.

Abstract: A method for obtaining a single-cell mRNA sequence, including: (1) capturing mRNA of a cell by using a cell tag carrier, and performing reverse transcription to obtain cDNA having a cell tag; (2) obtaining multiple cDNA fragments having molecular tags by using a transposase complex and a molecular tag carrier; (3) performing high-throughput sequencing; (4) performing sequence assembly according to the molecular tags to obtain the sequence of each mRNA; and (5) obtaining the sequence of all mRNAs of each single cell according to the cell tags.

Abstract: Techniques for context sensitive illustrated graphical user interface elements, comprising a social networking application. The social networking application may include, among other components, a social networking graphical elements management component to provide a list of recommended graphical element identifier information, in response to a request for the list of recommended graphical element identifier information, a context determination component to determine user context information representative of the at least one user context based at least partially on user communications intent information, user profile information, device location information, calendar event information, and/or external event information, and a graphical elements recommendation component to generate the list of recommended graphical element identifier information based at least partially on the user profile information, graphical elements promotion information, and/or the user context information.

Abstract: Provided are a method for detecting spatial information of nucleic acids in a sample, as well as a nucleic acid array used in the method and a method for producing the nucleic acid array.

Abstract: Techniques for context sensitive illustrated graphical user interface elements, comprising a social networking application. The social networking application may include, among other components, a social networking graphical elements management component to provide a list of recommended graphical element identifier information, in response to a request for the list of recommended graphical element identifier information, a context determination component to determine user context information representative of the at least one user context based at least partially on user communications intent information, user profile information, device location information, calendar event information, and/or external event information, and a graphical elements recommendation component to generate the list of recommended graphical element identifier information based at least partially on the user profile information, graphical elements promotion information, and/or the user context information.

Abstract: An electronic device includes: at least one connection interface, to receive an external signal. A first signal switching multiplexer is connected to the connection interface. A laptop system is connected to the first signal switching multiplexer, to operate in a laptop mode. A drawing board system is connected to the first signal switching multiplexer, to operate in a drawing board mode and an independent screen mode. A switching switch generates a switching signal and transmits it to the first signal switching multiplexer, the laptop system, and the drawing board system, to select the laptop mode, the drawing board mode, or the independent screen mode.