Abstract: A device for self-administration of physiologically active substances without the occurrence of overdosing, includes a container accommodating at least one substance and propellant means for propelling the substances out of the container, nozzle means connected to the container for discharging a substance, a valve connected between the nozzle and the container such that a predetermined amount of the substance is propelled from the container each time the valve has been opened, and manually activated electronic control means for opening the valve in response to manual activation of the electronic control means and for preventing opening of the valve greater than a predetermined number of times within a predetermined time period.

Abstract: A smoking substitute composition for application directly into the nose, consisting essentially of an aqueous solution of nicotine or a physiologically acceptable acid addition salt thereof, having a pH value of 2 to 6, containing 10 to 0.5% w/v of nicotine calculated as the free base, containing a nasally-acceptable thickening agent, and having a viscosity not less than 100 centipoise and optionally containing also a further ingredient selected from the group consisting of a nasally acceptable buffer, emulsifying agent, preservative, flavoring agent and antioxidant. A method of diminishing the desire of a subject to smoke comprising the step of administering to the subject a smoking substitute composition as set forth in the foregoing.