Patents by Inventor Owen B. Wallace

Owen B. Wallace has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclo 4.4.0 antiviral derivatives
    Patent number: 7037913
    Abstract: This invention provides compounds of Formula I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: May 2, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Tao Wang, Owen B. Wallace, Nicholas A. Meanwell, John F. Kadow, Zhongxing Zhang, Zhong Yang
  • Sulfonamide compounds and uses thereof
    Patent number: 6967196
    Abstract: In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the sulfur atom and nitrogen atom of the sulfonamide group include substituted or unsubstituted hydrocarbyl moieties, substituted or unsubstituted heterocycle moieties, polycyclic moieties, halogen, alkoxy, ether, ester, amide, sulfonyl, sulfonamidyl, sulfide, carbamate, and the like. Invention compounds are capable of a wide variety of uses. For example sulfonamide compounds can act to modulate production of amyloid ? protein and are useful in the prevention or treatment of a variety of diseases. Pharmaceutical compositions containing invention compounds are also provided. Such compositions have wide utility for the prevention or treatment of a variety of diseases.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: November 22, 2005
    Assignees: Bristol-Myers Squibb Company, Merck & Co. Inc.
    Inventors: David W. Smith, Benito Munoz, Kumar Srinivasan, Carl P. Bergstrom, Prasad V. Chaturvedula, Milind S. Deshpande, Daniel J. Keavy, Wai Yu Lau, Michael F. Parker, Charles P. Sloan, Owen B. Wallace, Henry Hui Wang
  • Antiviral azaindole derivatives
    Patent number: 6900323
    Abstract: The invention comprises novel azaindole intermediate compounds useful in the preparation of compounds of the class of azaindole piperazine diamide derivatives, composition thereof and their use as anti-viral agents, and particularly for treating HIV infection.
    Type: Grant
    Filed: July 16, 2003
    Date of Patent: May 31, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Tao Wang, Owen B. Wallace, Zhongxing Zhang, Nicholas A. Meanwell, John A. Bender
  • Indole, azaindole and related heterocyclic amidopiperazine derivatives
    Patent number: 6825201
    Abstract: The invention comprises substituted indole, azaindole and related heterocyclic amidopiperazine derivatives of general Formula I wherein: Q is —may represent a bond; A is selected from the group consisting of C1-6alkoxy, C1-6alkyl, C3-7cycloalkyl, phenyl, and heteroaryl; wherein said heteroaryl may be monocyclic or bicyclic and may be comprised of three to eleven atoms selected from the group consisting of C, N, NR9, O, and S, and wherein each ring of said phenyl and heteroaryl is optionally substituted with one to five same or different substituents selected from the group consisting of R19-R23; T is U is NR7, O, or S; V is C(H)kR1, O or N(R7′)k; W is CR3 or NR10; X is CR4 or NR10; Y is CR5 or NR10; Z is CR6 or NR10; k is 0 or 1; and m, n, and p are each independently 0, 1, or 2 provided that the sum of m, n, and p must equal 1 or 2; compositions thereof and their use as antiviral agents, particularly for treating HIV infection.
    Type: Grant
    Filed: April 22, 2002
    Date of Patent: November 30, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Tao Wang, Owen B. Wallace, Nicholas A. Meanwell, Zhongxing Zhang, John A. Bender, John F. Kadow, Kap-Sun Yeung
  • Antiviral azaindole derivatives
    Publication number: 20040023982
    Abstract: The present invention is directed to a series of chemical entitites that express HIV-1 inhibitory activities.
    Type: Application
    Filed: July 16, 2003
    Publication date: February 5, 2004
    Inventors: Tao Wang, Owen B. Wallace, Zhongxing Zhang, Nicholas A. Meanwell, John A. Bender
  • Bicyclo 4.4.0 antiviral derivatives
    Publication number: 20040009985
    Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
    Type: Application
    Filed: March 20, 2003
    Publication date: January 15, 2004
    Inventors: Tao Wang, Owen B. Wallace, Nicholas A. Meanwell, John F. Kadow, Zhongxing Zhang, Zhong Yang
  • Antiviral azaindole derivatives
    Patent number: 6632819
    Abstract: The invention comprises compounds of the class of azaindole piperazine diamide derivatives, compositions thereof and their use as anti-viral agents, and particularly for treating HIV infection.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: October 14, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Tao Wang, Owen B. Wallace, Zhongxing Zhang, Nicholas A. Meanwell, John A. Bender
  • Antiviral azaindole derivatives
    Publication number: 20030181463
    Abstract: The present invention is directed to a series of chemical entities that express HIV-1 inhibitory activities.
    Type: Application
    Filed: October 10, 2002
    Publication date: September 25, 2003
    Inventors: Tao Wang, Owen B. Wallace, Zhongxing Zhang, Nicholas A. Meanwell, John A. Bender
  • Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
    Patent number: 6573262
    Abstract: The invention comprises substituted indoleoxoacetic piperazine derivatives of general Formula I, compositions thereof and their use as antiviral agents, and particularly for treating HIV infection.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: June 3, 2003
    Assignee: Bristol-Myers Sqibb Company
    Inventors: Owen B. Wallace, Tao Wang, Kap-Sun Yeung, Bradley C. Pearce, Nicholas A. Meanwell, Zhilei Qiu, Haiquan Fang, Qiufen May Xue, Zhiwei Yin
  • Indole, azaindole and related heterocyclic amidopiperazine derivatives
    Publication number: 20030096825
    Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
    Type: Application
    Filed: April 22, 2002
    Publication date: May 22, 2003
    Inventors: Tao Wang, Owen B. Wallace, Nicholas A. Meanwell, Zhongxing Zhang, John A. Bender, John F. Kadow, Kap-Sun Yeung
  • Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
    Publication number: 20030069245
    Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with indoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
    Type: Application
    Filed: December 19, 2001
    Publication date: April 10, 2003
    Inventors: Owen B. Wallace, Tao Wang, Kap-Sun Yeung, Bradley C. Pearce, Nicholas A. Meanwell, Zhilei Qiu, Haiquan Fang, Qiufen May Xue, Zhiwei Yin
  • Antiviral azaindole derivatives
    Patent number: 6476034
    Abstract: The invention comprises compounds of the class of azaindole piperazine diamide derivatives, compositions thereof and their use as anti-viral agents, and particularly for treating HIV infection.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: November 5, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Tao Wang, Owen B. Wallace, Zhongxing Zhang, Nicholas A. Meanwell, John A. Bender
  • Antiviral indoleoxoacetyl piperazine derivatives
    Patent number: 6469006
    Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with indoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: October 22, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Wade S. Blair, Milind Deshpande, Haiquan Fang, Pin-Fang Lin, Timothy P. Spicer, Owen B. Wallace, Hui Wang, Tao Wang, Zhongxing Zhang, Kap-Sun Yeung
  • Antiviral azaindole derivatives
    Publication number: 20020119982
    Abstract: The present invention is directed to a series of chemical entities that express HIV-1 inhibitory activities.
    Type: Application
    Filed: July 25, 2001
    Publication date: August 29, 2002
    Inventors: Tao Wang, Owen B. Wallace, Zhongxing Zhang, Nicholas A. Meanwell, John A. Bender
  • Antiviral azaindole derivatives
    Publication number: 20020061892
    Abstract: The present invention is directed to a series of chemical entities that express HIV-1 inhibitory activities.
    Type: Application
    Filed: January 18, 2001
    Publication date: May 23, 2002
    Inventors: Tao Wang, Owen B. Wallace, Zhongxing Zhang, Nicholas A. Meanwell, John A. Bender