Abstract: An immunoresponsive cell, such as a T-cell expressing (i) a second generation chimeric antigen receptor comprising: (a) a signalling region; (b) a co-stimulatory signalling region; (c) a transmembrane domain; and (d) a binding element that specifically interacts with a first epitope on a target antigen; and (ii) a chimeric costimulatory receptor comprising (e) a co-stimulatory signalling region which is different to that of (b); (f) a transmembrane domain; and g) a binding element that specifically interacts with a second epitope on a target antigen. This arrangement is referred to as parallel chimeric activating receptors (pCAR). Cells of this type are useful in therapy, and kits and methods for using them as well as methods for preparing them are described and claimed.

Abstract: An immunoresponsive cell, such as a T-cell expressing (i) a second generation chimeric antigen receptor comprising: (a) a signalling region; (b) a co-stimulatory signalling region; (c) a transmembrane domain; and (d) a binding element that specifically interacts with a first epitope on a target antigen; and (ii) a chimeric costimulatory receptor comprising (e) a co-stimulatory signalling region which is different to that of (b); (f) a transmembrane domain; and g) a binding element that specifically interacts with a second epitope on a target antigen. This arrangement is referred to as parallel chimeric activating receptors (pCAR). Cells of this type are useful in therapy, and kits and methods for using them as well as methods for preparing them are described and claimed.

Abstract: An adjustable bracket assembly for a weight distribution system is shown and described herein. The adjustable bracket assembly may include a plurality of bracket members including at least a first bracket member, a second bracket member, a third bracket member, and a fourth bracket member arranged to be adjustable relative to one another and be selectively attached to a frame of a towed vehicle. The plurality of bracket members may be coupled to a plurality of fasteners to allow the plurality of bracket members to be adjusted relative to one another and to provide clamp forces relative to the frame of the towed vehicle. An attachment assembly may be coupled to the first bracket member and be configured to be attached to a spring arm of a weight distributing system that may be coupled to a towing vehicle.

Abstract: The present invention relates generally to a weight distribution system, and; more specifically, the present invention relates to a system of distributing weight of a towed vehicle to a towing vehicle and controlling sway of the towed vehicle relative to the towing vehicle. In one embodiment, the present invention relates to various different embodiments of a variable load rating spring arm (or spring bar) for a weight distribution systems.

Abstract: An adjustable bracket assembly for a weight distribution system is shown and described herein. The adjustable bracket assembly may include a plurality of bracket members including at least a first bracket member, a second bracket member, a third bracket member, and a fourth bracket member arranged to be adjustable relative to one another and be selectively attached to a frame of a towed vehicle. The plurality of bracket members may be coupled to a plurality of fasteners to allow the plurality of bracket members to be adjusted relative to one another and to provide clamp forces relative to the frame of the towed vehicle. An attachment assembly may be coupled to the first bracket member and be configured to be attached to a spring arm of a weight distributing system that may be coupled to a towing vehicle.

Abstract: An adjustable bracket assembly for a weight distribution system is shown and described herein. The adjustable bracket assembly may include a plurality of bracket members including at least a first bracket member, a second bracket member, a third bracket member, and a fourth bracket member arranged to be adjustable relative to one another and be selectively attached to a frame of a towed vehicle. The plurality of bracket members may be coupled to a plurality of fasteners to allow the plurality of bracket members to be adjusted relative to one another and to provide clamp forces relative to the frame of the towed vehicle. An attachment assembly may be coupled to the first bracket member and be configured to be attached to a spring arm of a weight distributing system that may be coupled to a towing vehicle.

Abstract: Disclosed is a pin box assembly that includes an adjustment assembly configured to adjust a range of pivotal movement of a towed vehicle related to a towing vehicle. The pin box assembly includes a towed vehicle attachment member, an elongated arm, and a king pin with an adjustment assembly. The adjustment assembly may include a wedge and an adjustment member that is configured to translate or pivot the wedge relative to the king pin to modify a range of angular rotation between the elongated arm and the fifth wheel hitch.

Abstract: An immunoresponsive cell, such as a T-cell expressing (i) a second generation chimeric antigen receptor comprising: (a) a signalling region; (b) a co-stimulatory signalling region; (c) a transmembrane domain; and (d) a binding element that specifically interacts with a first epitope on a target antigen; and (ii) a chimeric costimulatory receptor comprising (e) a co-stimulatory signalling region which is different to that of (b); (f) a transmembrane domain; and g) a binding element that specifically interacts with a second epitope on a target antigen. This arrangement is referred to as parallel chimeric activating receptors (pCAR). Cells of this type are useful in therapy, and kits and methods for using them as well as methods for preparing them are described and claimed.

Abstract: An immunoresponsive cell, such as a T-cell expressing (i) a second generation chimeric antigen receptor comprising: (a) a signalling region; (b) a co-stimulatory signalling region; (c) a transmembrane domain; and (d) a binding element that specifically interacts with a first epitope on a target antigen; and (ii) a chimeric costimulatory receptor comprising (e) a co-stimulatory signalling region which is different to that of (b); (f) a transmembrane domain; and g) a binding element that specifically interacts with a second epitope on a target antigen. This arrangement is referred to as parallel chimeric activating receptors (pCAR). Cells of this type are useful in therapy, and kits and methods for using them as well as methods for preparing them are described and claimed.

Abstract: An immunoresponsive cell, such as a T-cell expressing (i) a second generation chimeric antigen receptor comprising: (a) a signalling region; (b) a co-stimulatory signalling region; (c) a transmembrane domain; and (d) a binding element that specifically interacts with a first epitope on a target antigen; and (ii) a chimeric costimulatory receptor comprising (e) a co-stimulatory signalling region which is different to that of (b); (f) a transmembrane domain; and g) a binding element that specifically interacts with a second epitope on a target antigen. This arrangement is referred to as parallel chimeric activating receptors (pCAR). Cells of this type are useful in therapy, and kits and methods for using them as well as methods for preparing them are described and claimed.

Abstract: An immunoresponsive cell, such as a T-cell expressing (i) a second generation chimeric antigen receptor comprising: (a) a signalling region; (b) a co-stimulatory signalling region; (c) a transmembrane domain; and (d) a binding element that specifically interacts with a first epitope on a target antigen; and (ii) a chimeric costimulatory receptor comprising (e) a co-stimulatory signalling region which is different to that of (b); (f) a transmembrane domain; and g) a binding element that specifically interacts with a second epitope on a target antigen. This arrangement is referred to as parallel chimeric activating receptors (pCAR). Cells of this type are useful in therapy, and kits and methods for using them as well as methods for preparing them are described and claimed.

Abstract: An immunoresponsive cell, such as a T-cell expressing (i) a second generation chimeric antigen receptor comprising: (a) a signalling region; (b) a co-stimulatory signalling region; (c) a transmembrane domain; and (d) a binding element that specifically interacts with a first epitope on a target antigen; and (ii) a chimeric costimulatory receptor comprising (e) a co-stimulatory signalling region which is different to that of (b); (f) a transmembrane domain; and g) a binding element that specifically interacts with a second epitope on a target antigen. This arrangement is referred to as parallel chimeric activating receptors (pCAR). Cells of this type are useful in therapy, and kits and methods for using them as well as methods for preparing them are described and claimed.

Abstract: An immunoresponsive cell, such as a T-cell expressing (i) a second generation chimeric antigen receptor comprising: (a) a signalling region; (b) a co-stimulatory signalling region; (c) a transmembrane domain; and (d) a binding element that specifically interacts with a first epitope on a target antigen; and (ii) a chimeric costimulatory receptor comprising (e) a co-stimulatory signalling region which is different to that of (b); (f) a transmembrane domain; and (g) a binding element that specifically interacts with a second epitope on a target antigen. This arrangement is referred to as parallel chimeric activating receptors (pCAR). Cells of this type are useful in therapy, and kits and methods for using them as well as methods for preparing them are described and claimed.

Abstract: An immunoresponsive cell, such as a T-cell expressing (i) a second generation chimeric antigen receptor comprising: (a) a signalling region; (b) a co-stimulatory signalling region; (c) a transmembrane domain; and (d) a binding element that specifically interacts with a first epitope on a target antigen; and (ii) a chimeric costimulatory receptor comprising (e) a co-stimulatory signalling region which is different to that of (b); (f) a transmembrane domain; and (g) a binding element that specifically interacts with a second epitope on a target antigen. This arrangement is referred to as parallel chimeric activating receptors (pCAR). Cells of this type are useful in therapy, and kits and methods for using them as well as methods for preparing them are described and claimed.

Abstract: A borescope includes a flexible cable having a signal carrier disposed throughout a length of the flexible cable. An imager head illuminates an object proximate to the imager head. An articulating member is disposed between the flexible cable and the imager head. The articulating member includes a spring having a coiled wire defining a central cavity, and an axially incompressible member positioned in a spring central cavity extending from a connector attached to an end of the flexible cable to the imager head. The incompressible member permits angular deflection of the imager head with respect to the flexible cable while precluding axial compression of the coiled wire and individual coil-to-coil contact.