Patents by Inventor Owen HUGHES

Owen HUGHES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of SARM1 NADase activity and uses thereof
    Patent number: 11903935
    Abstract: The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: October 22, 2021
    Date of Patent: February 20, 2024
    Assignees: Washington University, Disarm Therapeutics, Inc.
    Inventors: Jeffrey Milbrandt, Kow Essuman, Yo Sasaki, Aaron Diantonio, Xianrong Mao, Rajesh Devraj, Raul Eduardo Krauss, Robert Owen Hughes
  • BENZOPYRAZOLE INHIBITORS OF SARM1
    Publication number: 20240051939
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: December 3, 2021
    Publication date: February 15, 2024
    Inventors: Todd Bosanac, Robert Owen Hughes, Rajesh Devraj, Shelley Anne Parrott
  • INDAZOLE DERIVATIVES AS INHIBITORS OF SARM1
    Publication number: 20230286978
    Abstract: The present disclosure provides compounds of formula (I) and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: April 7, 2021
    Publication date: September 14, 2023
    Inventors: Jonathan Bentley, Shelley Anne Parrott, Andrew Simon Brearley, Todd Bosanac, Robert Owen Hughes, Rajesh Devraj
  • CONDENSED PYRAZOLE DERIVATIVES AS INHIBITORS OF SARM1
    Publication number: 20230271957
    Abstract: The present disclosure provides compounds of formula (I) and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: April 7, 2021
    Publication date: August 31, 2023
    Inventors: Jonathan Bentley, JR., Shelley Anne Parrott, Andrew Simon Brearley, Todd Bosanac, Robert Owen Hughes, Rajesh Devraj
  • METHODS AND COMPOSITIONS FOR NEUROPROTECTION
    Publication number: 20230242909
    Abstract: The present invention relates to compositions and methods for treating neurodegeneration and neurodegenerative diseases associated with axonal degeneration. Neurodegeneration and neurodegenerative diseases associated with axonal degeneration are treated with therapies comprising SARM1 inhibitors such as SARM1 antisense oligonucleotides.
    Type: Application
    Filed: November 25, 2020
    Publication date: August 3, 2023
    Inventors: Liza LEVENTHAL, Thomas ENGBER, Raul Eduardo KRAUSS, Rajesh DEVRAJ, Robert Owen HUGHES, Todd BOSANAC, Sudhir AGRAWAL, Marco A. PASSINI
  • Inhibitors of SARM1
    Publication number: 20230008433
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: August 17, 2021
    Publication date: January 12, 2023
    Inventors: Jonathan BENTLEY, Todd BOSANAC, Andrew Simon BREARLEY, Sophie Catherine COOPER, Rajesh DEVRAJ, Robert Owen HUGHES, Richard Andrew JARJES-PIKE, Frederic Jacques MARLIN, Shelley Anne PARROTT, Daniel SILVA
  • INHIBITORS OF SARM1
    Publication number: 20220340546
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: June 12, 2020
    Publication date: October 27, 2022
    Inventors: Robert Owen HUGHES, Rajesh DEVRAJ, Todd BOSANAC, Richard Andrew JARJES-PIKE, Andrew Simon BREARLEY, Jonathan BENTLEY, Shelley Anne PARROTT, Sophie Catherine COOPER
  • INHIBITORS OF SARM1
    Publication number: 20220315568
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: September 11, 2020
    Publication date: October 6, 2022
    Inventors: Jonathan BENTLEY, Todd BOSANAC, Andrew Simon BREARLEY, Rajesh DEVRAJ, Robert Owen HUGHES
  • INHIBITORS OF SARM1
    Publication number: 20220242859
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration. In some embodiments, the present disclosure provides certain compounds and/or compositions that are useful in medicine, and particularly for treating neurodegeneration (e.g., for reducing axonal degeneration). In some embodiments, the present disclosure provides compounds having a structure as set forth in Formula (I).
    Type: Application
    Filed: June 5, 2020
    Publication date: August 4, 2022
    Inventors: Robert Owen HUGHES, Rajesh DEVRAJ, Todd BOSANAC, Richard Andrew JARJES-PIKE, Andrew BREARLEY, Jonathan BENTLEY
  • INHIBITORS OF SARM1
    Publication number: 20220194933
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: June 6, 2019
    Publication date: June 23, 2022
    Inventors: Robert Owen Hughes, Rajesh Devraj, Todd Bosanac, Richard Andrew Jarjes-Pike, Andrew Simon Brearley, Jonathan Bentley
  • Substituted pyrazino[2,3-b]pyrazines and pyrazino[2,3-c]pyridazines as modulators of ROR gamma
    Patent number: 11358967
    Abstract: The present invention encompasses compounds of the formula (I), wherein the variables are defined herein which are suitable for the modulation of ROR? and the treatment of diseases related to the modulation of ROR?. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: June 14, 2022
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Delphine Collin, Johanna Csengery, Robert Owen Hughes, Michael Robert Turner, Lifen Wu
  • INHIBITORS OF SARM1 IN COMBINATION WITH NAD+ OR A NAD+ PRECURSOR
    Publication number: 20220072019
    Abstract: The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and NAD+ or a NAD+ precursor.
    Type: Application
    Filed: October 18, 2019
    Publication date: March 10, 2022
    Inventors: Todd BOSANAC, Rajesh DEVRAJ, Thomas ENGBER, Robert Owen HUGHES, Raul Eduardo KRAUSS
  • Inhibitors of SARM1
    Publication number: 20220056013
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: August 23, 2021
    Publication date: February 24, 2022
    Inventors: Todd BOSANAC, Andrew Simon BREARLEY, Rajesh DEVRAJ, Robert Owen HUGHES, Richard Andrew JARJES-PIKE, Shelley Anne PARROTT
  • Inhibitors of SARM1 NADase activity and uses thereof
    Patent number: 11253503
    Abstract: The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: February 22, 2022
    Assignees: Washington University, Disarm Therapeutics, Inc.
    Inventors: Jeffrey Milbrandt, Kow Essuman, Yo Sasaki, Aaron DiAntonio, Xianrong Mao, Rajesh Devraj, Raul Eduardo Krauss, Robert Owen Hughes
  • INHIBITORS OF SARM1 NADASE ACTIVITY AND USES THEREOF
    Publication number: 20220040164
    Abstract: The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 22, 2021
    Publication date: February 10, 2022
    Inventors: Jeffrey MILBRANDT, Kow Essuman, Yo Sasaki, Aaron Diantonio, Xianrong Mao, Rajesh Devraj, Raul Eduardo Krauss, Robert Owen Hughes
  • INHIBITORS OF SARM1 IN COMBINATION WITH NEURO-PROTECTIVE AGENTS
    Publication number: 20220008405
    Abstract: The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and a neuroprotective agent.
    Type: Application
    Filed: December 18, 2019
    Publication date: January 13, 2022
    Inventors: Todd BOSANAC, Rajesh DEVRAJ, Thomas ENGBER, Robert Owen HUGHES, Raul Eduardo KRAUSS
  • INHIBITORS OF SARM1
    Publication number: 20210261540
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing neurodegenerative disease or axonal degeneration. The provided SARM1 inhibitors may reduce or inhibit binding of NAD+ by SARM1. Alternatively, provided SARM1 inhibitors bind to SARM1 within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARM1).
    Type: Application
    Filed: June 6, 2019
    Publication date: August 26, 2021
    Inventors: Robert Owen Hughes, Rajesh Devraj, Todd Bosanac, Richard Andrew Jarjes-Pike, Andrew Simon Brearley, Jonathan Bentley
  • INHIBITORS OF SARM1
    Publication number: 20210261537
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARMI and/or treating and/or preventing axonal degeneration. Provided SARMI inhibitors reduce or inhibit binding of NAD+ by SARMI and SARMI inhibitors bind to SARMI within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARMI).
    Type: Application
    Filed: June 6, 2019
    Publication date: August 26, 2021
    Inventors: Robert Owen Hughes, Rajesh Devraj, Todd Bosanac, Richard Andrew Jarjes-Pike, Andrew Simon Brearley, Jonathan Bentley
  • COMPOUNDS AS MODULATORS OF ROR GAMMA
    Publication number: 20210171527
    Abstract: The present invention encompasses compounds of the formula (I), wherein the variables are defined herein which are suitable for the modulation of ROR? and the treatment of diseases related to the modulation of ROR?. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.
    Type: Application
    Filed: January 18, 2017
    Publication date: June 10, 2021
    Inventors: Delphine COLLIN, Johanna CSENGERY, Robert Owen HUGHES, Michael Robert TURNER, Lifen WU
  • Compounds as modulators of ROR gamma
    Patent number: 10954215
    Abstract: The present invention encompasses compounds of the formula (I) wherein the variables are defined herein which are suitable for the modulation of ROR? and the treatment of diseases related to the modulation of ROR?. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: March 23, 2021
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Robert Owen Hughes, Xiang Li, Peter Allen Nemoto, Lana Louise Smith Keenan, Lifen Wu, Zhaoming Xiong