Abstract: Organizing a synchronous communication session can include determining, using a processor of a data processing system, a context responsive to detecting a trigger event. The context specifies a foreground application executing within the data processing system. Candidate participants can be determined from the context. A user interface is displayed separate from the foreground application. The user interface lists the candidate participants. Further, responsive to a user input received within the user interface, an invite to the candidate participants is sent. The invite specifies access information for the synchronous communication session.

Abstract: Organizing a synchronous communication session can include determining, using a processor of a data processing system, a context responsive to detecting a trigger event. The context specifies a foreground application executing within the data processing system. Candidate participants can be determined from the context. A user interface is displayed separate from the foreground application. The user interface lists the candidate participants. Further, responsive to a user input received within the user interface, an invite to the candidate participants is sent. The invite specifies access information for the synchronous communication session.

Abstract: Organizing a synchronous communication session can include determining, using a processor of a data processing system, a context responsive to detecting a trigger event. The context specifies a foreground application executing within the data processing system. Candidate participants can be determined from the context. A user interface is displayed separate from the foreground application. The user interface lists the candidate participants. Further, responsive to a user input received within the user interface, an invite to the candidate participants is sent. The invite specifies access information for the synchronous communication session.

Abstract: The invention relates to new compounds that reduce c-Myc expression and useful for cancer treatment, particularly hematological cancers such as aggressive B- and T-cell lymphomas. The new compounds may be combined with adjunct c-Myc inhibor agents such as a PI3K inhibitor, CK-1 inhibitor, Akt-inhibitor, proteasome inhibitor and/or mTor inhibitor. The c-Myc reducing agent may be provided as a lead-in treatment to reduce or initiate reduction of c-Myc prior to adminstration of the adjunct cancer therapeutic agent. Treatment with a c-Myc reducing agent modulates the disease state of the c-Myc overexpressing cancer making it less malignant and more susceptible to adjunctive cancer therapies.

Abstract: The invention relates to the co-administration of select proteasome and PI3K inhibitors is useful for treating c-Myc-overexpressing cancers, particularly hematological cancers such as aggressive B- and T-cell lymphomas. In exemplified embodiments, coadministration of a dual PI3K/CK-1 inhibitor with a proteasome inhibitor synergistically increases cell death of aggressive B- and T-cell lymphomas as well as multiple myeloma over the individual or additive effect of either or both agents. This synergistic effect is associated with the previously unknown inhibition of the kinase casein kinase 1 epsilon (CK-1?) by a PI3K inhibitor, such as TGR-1202. Accordingly, use of PI3K inhibitors that possess CK-1? inhibition in combination with proteasome inhibitors provides a new therapy regime for treating c-Myc-overexpressing cancers, and particularly hematological cancers.

Abstract: The present invention relates to the NQBS class of molecules. It is based, at least in part, on the discovery that a representative group of compounds have been observed to inhibit nuclear translocation of NF-?B subunits. Without being bound by any particular theory, this inhibition of nuclear translocation may be mediated by either (i) binding of the NQBS or related compound to the C-terminus of the RHD, which specifically mediates the nuclear internalization; or (ii) NQBS-mediated stabilization of the dimer/I?B complex, disallowing dissociation of the active NF-?B monomers, and thus, inhibiting the generation of the subunits necessary to enter the nucleus. The NQBS class of molecules, and related molecules, may be used in therapeutic applications where inhibition of NF-?B translocation is beneficial, including but not limited to the treatment of cancer, autoimmune disorders, and inflammatory states.

Abstract: Organizing a synchronous communication session can include determining, using a processor of a data processing system, a context responsive to detecting a trigger event. The context specifies a foreground application executing within the data processing system. Candidate participants can be determined from the context. A user interface is displayed separate from the foreground application. The user interface lists the candidate participants. Further, responsive to a user input received within the user interface, an invite to the candidate participants is sent. The invite specifies access information for the synchronous communication session.

Abstract: Organizing a synchronous communication session can include determining, using a processor of a data processing system, a context responsive to detecting a trigger event. The context specifies a foreground application executing within the data processing system. Candidate participants can be determined from the context. A user interface is displayed separate from the foreground application. The user interface lists the candidate participants. Further, responsive to a user input received within the user interface, an invite to the candidate participants is sent. The invite specifies access information for the synchronous communication session.

Abstract: A global licensing service facilitates the mapping of consumers to purchases made by the consumer in one or more stores. One or more consumer identifiers used by a consumer in various stores are stored in a central data store. The various consumer identifiers are mapped to purchases made by the consumer to provide a centralized transaction mapping. The global licensing service may enable cross-store licensing by providing a way in which a store may determine that a consumer has previously purchased a product in another store. In some implementations, if the consumer has previously purchased a product, the consumer may be offered the product for free or offered a discount price for the product.

Abstract: Methods for treating a subject with cancer using a combined therapeutic regimen comprising administering propolis or caffeic acid phenethyl ester (CAPE) in conjunction with other cancer therapeutics are described herein. More particularly, methods for treating subjects with breast cancer using the combined therapeutic regimen are embodied herein. The present methods are particularly useful for treating cancer patients (e.g., breast cancer patients) who are refractory to or who have become refractory to the cancer therapeutic/s used in combination with propolis or CAPE. Propolis or CAPE for use in a combined treatment with other cancer therapeutics for treating cancer patients and compositions comprising propolis or CAPE and other cancer therapeutics are also encompassed herein wherein the ability of propolis or CAPE to act as a histone deacetylase (HDAC) inhibitor is used to advantage.

Abstract: The present invention relates to the NQBS class of molecules. It is based, at least in part, on the discovery that a representative group of compounds have been observed to inhibit nuclear translocation of NF-?B subunits. Without being bound by any particular theory, this inhibition of nuclear translocation may be mediated by either (i) binding of the NQBS or related compound to the C-terminus of the RHD, which specifically mediates the nuclear internalization; or (ii) NQBS-mediated stabilization of the dimer/I?B complex, disallowing dissociation of the active NF-?B monomers, and thus, inhibiting the generation of the subunits necessary to enter the nucleus. The NQBS class of molecules, and related molecules, may be used in therapeutic applications where inhibition of NF-?B translocation is beneficial, including but not limited to the treatment of cancer, autoimmune disorders, and inflammatory states.

Abstract: A system for monitoring the availability of support members includes an application program (heartbeat application) that runs on a handheld device and an associated program that runs on a heartbeat server. The heartbeat application collects status information of the handheld device. The handheld device periodically transmits the status information to the heartbeat server in a digital data message that has a format adapted to an operation mode of the handheld device. Based on the status information, the availability of the data connection to the handheld device is determined.

Abstract: A system and method for automatic data mapping of a source object to a target object. Field maps can be automatically determined from the source and target objects, database platform, ETL maps, user-defined and data conversion rules, default values, or other pre-defined parameters. Where a change occurs in the source or target data structure, the present invention ensures proper mapping between the source and target data structures occurs, thus reducing the burden of exception handling on the user and preventing oversight in correcting improper mapping. The present invention can also be used by a compiler to generate SQL steps during compile-time processes to design field maps that can be stored as an application class.

Abstract: A system for monitoring the availability of support members includes an application program (heartbeat application) that runs on a handheld device and an associated program that runs on a heartbeat server. The heartbeat application collects status information of the handheld device. The handheld device periodically transmits the status information to the heartbeat server in a digital data message that has a format adapted to an operation mode of the handheld device. Based on the status information, the availability of the data connection to the handheld device is determined.

Abstract: Lymphoma is treated using therapeutic combinations of PDX and gemcitabine by administering to a patient suffering from lymphoma a therapeutically effective amount of PDX in combination with a therapeutically effective amount of gemcitabine. The two agents can be administered together or in either order, although administration of PDX followed by gemcitabine is preferred. As in the case of MTX and Ara-C, synergism is observed, but the extent of the synergism is greater. Further, test results indicate that mechanism of action for combinations of PDX and Gem is different than for MTX and Ara-C, with more emphasis on induction of apoptosis.

Abstract: A system and method for automatic data mapping of a source object to a target object. Field maps can be automatically determined from the source and target objects, database platform, ETL maps, user-defined and data conversion rules, default values, or other pre-defined parameters. Where a change occurs in the source or target data structure, the present invention ensures proper mapping between the source and target data structures occurs, thus reducing the burden of exception handling on the user and preventing oversight in correcting improper mapping. The present invention can also be used by a compiler to generate SQL steps during compile-time processes to design field maps that can be stored as an application class.

Abstract: A fuel filter includes a first filter chamber, a second filter chamber and a valve assembly disposed between the first and second filter chambers. The valve assembly includes a valve casing with a valve head connected to a flag indicator slidably disposed within the valve casing and movable between a first and second position. A port located in the valve casing allows fuel to flow from the first filter chamber to the second filter chamber when the valve head and flag indicator moves from the first position to the second position. A transparent portion of the valve casing allows the flag indicator to be visible in the second position allowing a user to determine that the fuel filter must be serviced or removed and replaced.

Abstract: T cell lymphoma is treated by administering to a patient suffering from T cell lymphoma a therapeutically effective amount of 10-propargyl-10-deazaaminopterin. Remission is observed in human patients, even with drug resistant T cell lymphoma at weekly dosages levels as low as 30 mg/m2. In general, the 10-propargyl-10-deazaaminopterin is administered in an amount of from 30 to 275 mg/m2 per dose.

Abstract: In the risk management system of the present invention, an inspector utilizes a personal digital assistant to assess the condition of inspection points on a structure, such as a steel marine structure. The inspection points are subjected to environmental conditions such as seawater, air, elevated temperatures, chemicals and operational stresses, all of which can have a direct influence on the structure's building media (steel). The PDA is pre-loaded with the risk management system which is comprised of one or more previously quantified drop down menus or boxes from which an inspector can choose defined selections. Based upon initial selections by the inspector, such as defining the location and environment of the structure, the system determines how the drop down box will be populated. The inspector selects the item in the menu box that best categorizes the status of each inspection point.

Abstract: A method and system for automatically mapping areas of poor coverage in a cellular network uses signal quality information and mobile station location information. The system constructs a visual map that notes the locations of mobile stations when poor base station-mobile station communication signal quality is reported. The visual map can be used for identifying areas of the network that may require remediation to ensure sufficient network coverage.