Patents by Inventor Owen Shea

Owen Shea has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230338577
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Application
    Filed: May 2, 2023
    Publication date: October 26, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • Patent number: 11679165
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: June 20, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • Patent number: 11491228
    Abstract: Provided herein are polymers of Formula (I), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, compositions, and formulations thereof. The polymers described herein are biocompatible, non-toxic, water compatible, and operationally simple to formulate. Also provided are methods and kits involving the polymers described herein (e.g., methods of using polymers described herein for delivering agents (e.g., for therapeutic, diagnostic, prophylactic, imaging, ophthalmic, intraoperative, or cosmetic use) to a subject, cell, tissue, or biological sample, as part of materials (e.g., biodegradable materials, biocompatible materials, wound dressing (e.g., bandages), drug depots, coatings), or as scaffolds for tissue engineering. Provided are methods for synthesizing the polymers described herein, and polymers described herein synthesized by the synthetic methods described herein.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: November 8, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Robert S. Langer, Owen Shea Fenton, Jason Andresen, Marion Paolini
  • Publication number: 20210349272
    Abstract: An optical transceiver may include a circuit board, lasers, and a PLC including optical multiplexers and demultiplexers. The PLC may be coupled to fiber optic lines at a forward edge of the PLC, with a rear edge of the PLC receiving light for transmission generated by the lasers. Light received at the forward edge of the PLC may be demultiplexed into data channels and routed to a top surface of the PLC for optoelectronic conversion by photodetectors. In some embodiments each data channel is routed into a corresponding plurality of waveguides, with each of the corresponding plurality of waveguides providing light to the same photodetector. In some embodiments at least some receive side electronic circuitry, other than photodetectors, is stacked on top of the PLC.
    Type: Application
    Filed: December 17, 2020
    Publication date: November 11, 2021
    Inventors: Bardia Pezeshki, Hindrik Bulthuis, Ramsey Selim, Andrew Grant, Lucas Soldano, Owen Shea, Josef Wendland, Jamie Stokes, Suresh Rangarajan, Josh Oen, Ron Zhang, Rob Kalman, Drew Lundsten
  • Publication number: 20200386956
    Abstract: An optical transceiver may include a circuit board, lasers, and a PLC including optical multiplexers and demultiplexers. The PLC may be coupled to fiber optic lines at a forward edge of the PLC, with a rear edge of the PLC receiving light for transmission generated by the lasers. Light received at the forward edge of the PLC may be demultiplexed into data channels and routed to a top surface of the PLC for optoelectronic conversion by photodetectors. In some embodiments each data channel is routed into a corresponding plurality of waveguides, with each of the corresponding plurality of waveguides providing light to the same photodetector. In some embodiments at least some receive side electronic circuitry, other than photodetectors, is stacked on top of the PLC.
    Type: Application
    Filed: December 20, 2019
    Publication date: December 10, 2020
    Inventors: Bardia Pezeshki, Hendrick Bulthuis, Ramsey Selim, Andrew Grant, Lucas Soldano, Owen Shea, Josef Wendland, Jamie Stokes, Suresh Rangarajan, Josh Oen, Ron Zhang, Rob Kalman, Drew Lundsten
  • Publication number: 20200353099
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Application
    Filed: May 20, 2020
    Publication date: November 12, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • Patent number: 10695444
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: June 30, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • Publication number: 20200009256
    Abstract: Provided herein are polymers of Formula (I), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, compositions, and formulations thereof. The polymers described herein are biocompatible, non-toxic, water compatible, and operationally simple to formulate. Also provided are methods and kits involving the polymers described herein (e.g., methods of using polymers described herein for delivering agents (e.g., for therapeutic, diagnostic, prophylactic, imaging, ophthalmic, intraoperative, or cosmetic use) to a subject, cell, tissue, or biological sample, as part of materials (e.g., biodegradable materials, biocompatible materials, wound dressing (e.g., bandages), drug depots, coatings), or as scaffolds for tissue engineering. Provided are methods for synthesizing the polymers described herein, and polymers described herein synthesized by the synthetic methods described herein.
    Type: Application
    Filed: July 3, 2019
    Publication date: January 9, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Robert S. Langer, Owen Shea Fenton, Jason Andresen, Marion Paolini
  • Publication number: 20190278035
    Abstract: An optical transceiver may include a circuit board, lasers, and a PLC including optical multiplexers and demultiplexers. The PLC may be coupled to fiber optic lines at a forward edge of the PLC, with a rear edge of the PLC receiving light for transmission generated by the lasers. Light received at the forward edge of the PLC may be demultiplexed into data channels and routed to a top surface of the PLC for optoelectronic conversion by photodetectors. In some embodiments each data channel is routed into a corresponding plurality of waveguides, with each of the corresponding plurality of waveguides providing light to the same photodetector. In some embodiments at least some receive side electronic circuitry, other than photodetectors, is stacked on top of the PLC.
    Type: Application
    Filed: March 11, 2019
    Publication date: September 12, 2019
    Inventors: Bardia Pezeshki, Hendrick Bulthuis, Ramsey Selim, Andrew Grant, Lucas Soldano, Owen Shea, Josef Wendland, Jamie Stokes, Suresh Rangarajan, Josh Oen, Ron Zhang, Rob Kalman, Drew Lundsten
  • Publication number: 20190240349
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Application
    Filed: February 6, 2019
    Publication date: August 8, 2019
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • Patent number: 10201618
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: February 12, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • Patent number: 10054739
    Abstract: An optical transceiver may include pairs of lasers, each laser of a particular pair generating light at the same wavelength and each pair of lasers generating light at different wavelengths. The light from the lasers may be demultiplexed onto a pair of outputs, with each output receiving light from different lasers of each pair of lasers.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: August 21, 2018
    Assignee: Kaiam Corp.
    Inventors: Owen Shea, Bardia Pezeshki, Andrew Grant, Jamie Stokes, Henk Bulthuis, Dinh Ton, Ramsey Selim
  • Publication number: 20180081117
    Abstract: An optical transceiver may include pairs of lasers, each laser of a particular pair generating light at the same wavelength and each pair of lasers generating light at different wavelengths. The light from the lasers may be demultiplexed onto a pair of outputs, with each output receiving light from different lasers of each pair of lasers.
    Type: Application
    Filed: September 18, 2017
    Publication date: March 22, 2018
    Inventors: Owen Shea, Bardia Pezeshki, Andrew Grant, Jamie Stokes, Henk Bulthuis, Dinh Ton, Ramsey Selim
  • Patent number: 9840479
    Abstract: The present disclosure provides polyamine-fatty acid derived lipidoids (e.g., compounds of Formula (I) or (II)) and methods of preparing the lipidoids. A described lipidoid includes R—C(?O)—O— moieties (where R is a lipid moiety), which may be hydrolyzed into non-toxic fatty acids. Also provided are compositions including a described lipidoid and an agent (e.g., polynucleotide, small molecule, peptide, or protein). The present disclosure also provides methods, kits, and uses that involve the lipidoids or compositions for delivering an agent to a subject, tissue, or cell and/or for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases, respiratory diseases, painful conditions, psychiatric disorders, and metabolic disorders.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: December 12, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Owen Shea Fenton, Joseph Robert Dorkin, Daniel Griffith Anderson, Rebecca L. McClellan
  • Publication number: 20160367686
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Application
    Filed: June 17, 2016
    Publication date: December 22, 2016
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • Publication number: 20160002178
    Abstract: The present disclosure provides polyamine-fatty acid derived lipidoids (e.g., compounds of Formula (I) or (II)) and methods of preparing the lipidoids. A described lipidoid includes R—C(?O)—O— moieties (where R is a lipid moiety), which may be hydrolyzed into non-toxic fatty acids. Also provided are compositions including a described lipidoid and an agent (e.g., polynucleotide, small molecule, peptide, or protein). The present disclosure also provides methods, kits, and uses that involve the lipidoids or compositions for delivering an agent to a subject, tissue, or cell and/or for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases, respiratory diseases, painful conditions, psychiatric disorders, and metabolic disorders.
    Type: Application
    Filed: July 1, 2015
    Publication date: January 7, 2016
    Applicant: Massachusetts Institute of Technology
    Inventors: Owen Shea Fenton, Joseph Robert Dorkin, Daniel Griffith Anderson, Rebecca L. McClellan
  • Patent number: 4025435
    Abstract: Paint filtering apparatus for supporting a filter medium, such as foraminous cloth or the like, above a paint pail. The apparatus includes an impervious plate larger than the mouth of the paint pail and legs for supporting the plate above a surface on which the paint pail can be rested. The plate defines a circular opening having a diameter smaller than the diameter of the mouth of the paint pail. A cylindric rim that is sized to fit within the hole in the plate and having protrusions fastened thereto for bearing on the plate to retain the rim in place. Above the protrusions the rim defines an annular groove, and there is a strap that can be placed in the groove to retain the filter medium within the groove throughout the extent thereof. The rim is smaller than the diameter of a paint bucket so that a paint bucket can be rested on the rim in an inverted position to afford draining of the same without continuing attention.
    Type: Grant
    Filed: July 25, 1975
    Date of Patent: May 24, 1977
    Inventor: Dennis Owen Shea