Abstract: The present disclosure provides materials and methods for mapping specific protein-DNA interactions genome-wide, including highly repetitive areas of the genome, by performing targeted modifications of base-pairs at or near the genomic site where a protein of interest is interacting, followed by direct detection of those modified base-pairs using long-read DNA sequencing.

Abstract: A system for supporting a user's repetitive motion activity operates to manage cadence-based playlists identifying one or more media content items having a tempo corresponding to a user's cadence. The cadence-based playlists can be categorized by different tempi or tempo ranges that cover all likely cadences during the user's activities. A media-playback device is provided to acquire a user's cadence and retrieve a cadence-based playlist associated with a tempo or a tempo range corresponding to the cadence.

Abstract: A carriage includes an elongated body having a first end and an opposing second end and a flange coupled to the first end of the elongated body. The flange includes a first portion having a first face and an opposing second face. The first portion defines a first aperture having a first diameter. The first portion includes (i) at least two first retainers protruding outward from the first face and extending at least partially over the first aperture and (ii) at least two second retainers protruding outward from the opposing second face and extending at least partially over the first aperture. The first retainers and the second retainers define a second diameter that is less than the first diameter. The first aperture, the first retainers, and the second retainers are configured to accommodate ball bearings having diameters between about 4.6 mm and about 5.4 mm.

Abstract: A system for supporting a user’s repetitive motion activity operates to manage cadence-based playlists identifying one or more media content items having a tempo corresponding to a user’s cadence. The cadence-based playlists can be categorized by different tempi or tempo ranges that cover all likely cadences during the user’s activities. A media-playback device is provided to acquire a user’s cadence and retrieve a cadence-based playlist associated with a tempo or a tempo range corresponding to the cadence.

Abstract: A system for supporting a user's repetitive motion activity operates to manage cadence-based playlists identifying one or more media content items having a tempo corresponding to a user's cadence. The cadence-based playlists can be categorized by different tempi or tempo ranges that cover all likely cadences during the user's activities. A media-playback device is provided to acquire a user's cadence and retrieve a cadence-based playlist associated with a tempo or a tempo range corresponding to the cadence.

Abstract: Systems, devices, apparatuses, components, methods, and techniques for repetitive-motion activity enhancement based upon media content selection are provided. An example media-playback device for enhancement of a repetitive-motion activity includes a media-output device that plays media content items, a plurality of media content selection engines, and a repetitive-activity enhancement mode selection engine. The plurality of media content selection engines includes a cadence-based media content selection engine and an enhancement program engine. The cadence-based media content selection engine is configured to select media content items based on a cadence associated with the repetitive-motion activity. The enhancement program engine is configured to select a media content items according to an enhancement program for the repetitive-motion activity.

Abstract: A media-playback device includes: a media-output device that plays media content items; a physiological measurement device programmed to measure at least one physiological measurement of a user of the media-output device; and a physiological control engine configured to: identify a current physiological measurement for the user; and cause the media-output device to modify playback of the media content items based upon the current physiological measurement.

Abstract: Systems, devices, apparatuses, components, methods, and techniques for repetitive-motion activity enhancement based upon media content selection are provided. An example media-playback device for enhancement of a repetitive-motion activity includes a media-output device that plays media content items, a plurality of media content selection engines, and a repetitive-activity enhancement mode selection engine. The plurality of media content selection engines includes a cadence-based media content selection engine and an enhancement program engine. The cadence-based media content selection engine is configured to select media content items based on a cadence associated with the repetitive-motion activity. The enhancement program engine is configured to select a media content items according to an enhancement program for the repetitive-motion activity.

Abstract: Systems, devices, apparatuses, components, methods, and techniques for cadence determination and media content selection are provided. An example media-playback device comprises a media-output device that plays media content items, a cadence-acquiring device, and a cadence-based media content selection engine. The cadence-acquiring device includes an accelerometer and a cadence-determination engine configured to determine a cadence based on acceleration data captured by the accelerometer. The cadence-based media content selection engine is configured to identify a media content item based on the cadence determined by the cadence-determining engine and cause the media-output device to playback the identified media content item.

Abstract: Systems, devices, apparatuses, components, methods, and techniques for repetitive-motion activity enhancement based upon media content selection are provided. An example media-playback device for enhancement of a repetitive-motion activity includes a media-output device that plays media content items, a plurality of media content selection engines, and a repetitive-activity enhancement mode selection engine. The plurality of media content selection engines includes a cadence-based media content selection engine and an enhancement program engine. The cadence-based media content selection engine is configured to select media content items based on a cadence associated with the repetitive-motion activity. The enhancement program engine is configured to select a media content items according to an enhancement program for the repetitive-motion activity.

Abstract: A system for supporting a user's repetitive motion activity operates to manage cadence-based playlists identifying one or more media content items having a tempo corresponding to a user's cadence. The cadence-based playlists can be categorized by different tempi or tempo ranges that cover all likely cadences during the user's activities. A media-playback device is provided to acquire a user's cadence and retrieve a cadence-based playlist associated with a tempo or a tempo range corresponding to the cadence.

Abstract: A media-playback device includes: a media-output device that plays media content items; a physiological measurement device programmed to measure at least one physiological measurement of a user of the media-output device; and a physiological control engine configured to: identify a current physiological measurement for the user; and cause the media-output device to modify playback of the media content items based upon the current physiological measurement.

Abstract: Systems, devices, apparatuses, components, methods, and techniques for repetitive-motion activity enhancement based upon media content selection are provided. An example media-playback device for enhancement of a repetitive-motion activity includes a media-output device that plays media content items, a plurality of media content selection engines, and a repetitive-activity enhancement mode selection engine. The plurality of media content selection engines includes a cadence-based media content selection engine and an enhancement program engine. The cadence-based media content selection engine is configured to select media content items based on a cadence associated with the repetitive-motion activity. The enhancement program engine is configured to select a media content items according to an enhancement program for the repetitive-motion activity.

Abstract: A media-playback device includes: a media-output device that plays media content items; a physiological measurement device programmed to measure at least one physiological measurement of a user of the media-output device; and a physiological control engine configured to: identify a current physiological measurement for the user; and cause the media-output device to modify playback of the media content items based upon the current physiological measurement.

Abstract: A system for supporting a user's repetitive motion activity operates to manage cadence-based playlists identifying one or more media content items having a tempo corresponding to a user's cadence. The cadence-based playlists can be categorized by different tempi or tempo ranges that cover all likely cadences during the user's activities. A media-playback device is provided to acquire a user's cadence and retrieve a cadence-based playlist associated with a tempo or a tempo range corresponding to the cadence.

Abstract: A media-playback device includes: a media-output device that plays media content items; a physiological measurement device programmed to measure at least one physiological measurement of a user of the media-output device; and a physiological control engine configured to: identify a current physiological measurement for the user; and cause the media-output device to modify playback of the media content items based upon the current physiological measurement.

Abstract: Systems, devices, apparatuses, components, methods, and techniques for cadence determination and media content selection are provided. An example media-playback device comprises a media-output device that plays media content items, a cadence-acquiring device, and a cadence-based media content selection engine. The cadence-acquiring device includes an accelerometer and a cadence-determination engine configured to determine a cadence based on acceleration data captured by the accelerometer. The cadence-based media content selection engine is configured to identify a media content item based on the cadence determined by the cadence-determining engine and cause the media-output device to playback the identified media content item.

Abstract: Systems, devices, apparatuses, components, methods, and techniques for cadence determination and media content selection are provided. An example media-playback device comprises a media-output device that plays media content items, a cadence-acquiring device, and a cadence-based media content selection engine. The cadence-acquiring device includes an accelerometer and a cadence-determination engine configured to determine a cadence based on acceleration data captured by the accelerometer. The cadence-based media content selection engine is configured to identify a media content item based on the cadence determined by the cadence-determining engine and cause the media-output device to playback the identified media content item.

Abstract: A media-playback device includes: a media-output device that plays media content items; a physiological measurement device programmed to measure at least one physiological measurement of a user of the media-output device; and a physiological control engine configured to: identify a current physiological measurement for the user; and cause the media-output device to modify playback of the media content items based upon the current physiological measurement.

Abstract: Systems, devices, apparatuses, components, methods, and techniques for repetitive-motion activity enhancement based upon media content selection are provided. An example media-playback device for enhancement of a repetitive-motion activity includes a media-output device that plays media content items, a plurality of media content selection engines, and a repetitive-activity enhancement mode selection engine. The plurality of media content selection engines includes a cadence-based media content selection engine and an enhancement program engine. The cadence-based media content selection engine is configured to select media content items based on a cadence associated with the repetitive-motion activity. The enhancement program engine is configured to select a media content items according to an enhancement program for the repetitive-motion activity.