Abstract: The present invention relates generally to a method of modulating cellular functioning. More particularly, the present invention relates to a method of modulating B cell functioning, for example B cell proliferation, utilising an IDO-mediated tryptophan metabolite as herein defined (particular examples of such IDO-mediated tryptophan metabolites include 3-hydroxykynurenic acid, 3-hydroxyanthranilic acid, picolinic acid, quinolinic acid and tranilast). The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate B cell functioning such as antibody production, autoimmune conditions and B cell proliferation and neoplasias. In a related aspect, the present invention is directed to a method of therapeutically and/or prophylactically treating rheumatoid arthritis via the administration of the above-mentioned compounds.

Abstract: The present invention relates generally to the area of pain management and more particularly, to a method of analgesia and agents useful for same. More particularly, the present invention relates to a method of analgesia utilising a compound of formula (I). The method of the present invention is useful, inter alia, in the therapeutic or prophylactic treatment of pain, including acute pain, chronic non-malignant pain and chronic malignant pain. Also provided are compounds for use in the method of the invention.

Abstract: A method for reducing the odors of an anaerobically digested dewatered biosolids or other biosolids or sludge may include separating first anaerobically digested dewatered biosolids into first and second portions, storing second anaerobically digested dewatered biosolids, removing a portion of the second biosolids, and mixing the removed second biosolids portion with the first portion of the first biosolids. The method may be implemented in a system including a separation device, first, second and third transporters, a storage area, and a mixer. The separation device may separate the first biosolids into first and second portions. The first transporter may transport the first portion to the mixer. The second transporter may transport the second portion to the storage area. The storage area may store the second portion for a select time period. The third transporter may transport a portion of the stored first biosolids to the mixer for blending.

Abstract: Various embodiments of the present invention provide for enhanced calendaring functionality in a collaboration suite application. A mini-calendar display in different views of the collaboration suite application provide for an easy way to view, edit and/or add appointments without needing to open of the calendar in the collaboration suite application. Email messages can be dragged onto days in the mini-calendar to create meeting proposals. Enhanced UI allows for different meetings being having different appearances based on whether they have been accepted, rejected, etc. Multiple calendars can be viewed simultaneously and their cumulative availability for any time slot can be easily seen via a calendar thermometer. Requests for sharing of calendars can be communicated via email messages, and they can be seamlessly responded to within the email message itself.

Abstract: A method for reducing the odors of an anaerobically digested dewatered biosolids or other biosolids or sludge may include separating first anaerobically digested dewatered biosolids into first and second portions, storing second anaerobically digested dewatered biosolids, removing a portion of the second biosolids, and mixing the removed second biosolids portion with the first portion of the first biosolids. The method may be implemented in a system including a separation device, first, second and third transporters, a storage area, and a mixer. The separation device may separate the first biosolids into first and second portions. The first transporter may transport the first portion to the mixer. The second transporter may transport the second portion to the storage area. The storage area may store the second portion for a select time period. The third transporter may transport a portion of the stored first biosolids to the mixer for blending.

Abstract: A wireless adaptor for a portable electronic device enables the electronic device to communicate over wireless networks with remote devices. The wireless adapter includes a communication circuit configured to communicate data with a remote device over a wireless network. The wireless adaptor may further include a battery and a power control circuit operatively connected to the battery and the communication circuit. The power control circuit is configured to provide at least supplemental power from the battery to the communication circuit.

Abstract: A logic circuit for generating a control voltage includes a ramp DAC and a main DAC. When the control voltage is needed, such as when an associated crystal oscillator is being “turned on,” an input reference voltage is supplied to both the ramp DAC and the main DAC. The ramp DAC generates an output based on the input reference voltage and L supplied control bits for a (preferably short) ramp time period. The output from the ramp DAC is fed to a filter circuit that includes a capacitor to charge the capacitor and the control voltage is generated at least in part from the ramp DAC output as filtered by the capacitor. When the ramp period ends, the state of the input reference voltage is changed and the output from the main DAC, based on the changed input reference voltage and N control bits, is input to the filter.