Patents by Inventor Oxana A. Malakhova

Oxana A. Malakhova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for protein expression and purification
    Patent number: 7820384
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: October 26, 2010
    Assignee: Lifesensors, Inc.
    Inventors: Tauseef R. Butt, Steven D. Weeks, Hiep T. Tran, Míchael P. Malakhov, Oxana A. Malakhova
  • Methods and compositions for enhanced protein expression and purification
    Patent number: 7655413
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: February 2, 2010
    Assignee: Lifesensors, Inc.
    Inventors: Tauseef R. Butt, Oxana A. Malakhova, Michael P. Malakhov
  • Methods and Compositions for Protein Expression and Purification
    Publication number: 20070259414
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Application
    Filed: May 21, 2007
    Publication date: November 8, 2007
    Inventors: Tauseef Butt, Stephen Weeks, Hiep Tran, Michael Malakhov, Oxana Malakhova
  • Methods and compositions for protein expression and purification
    Patent number: 7220576
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Grant
    Filed: March 14, 2003
    Date of Patent: May 22, 2007
    Assignee: Lifesensors, Inc.
    Inventors: Tauseef R. Butt, Steven D. Weeks, Hiep T. Tran, Michael P. Malakhov, Oxana A. Malakhova
  • Methods and compositions for enhanced protein expression and purification
    Publication number: 20070037246
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Application
    Filed: June 28, 2004
    Publication date: February 15, 2007
    Inventors: Tauseef Butt, Oxana Malakhova, Michael Malakhov
  • Methods and compositions for protein expression and purification
    Publication number: 20060216785
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Application
    Filed: February 28, 2006
    Publication date: September 28, 2006
    Inventors: Tauseef Butt, Steven Weeks, Hiep Tran, Michael Malakhov, Oxana Malakhova
  • Methods and compositions for protein expression and purification
    Patent number: 7060461
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: June 13, 2006
    Assignee: Lifesensors, Inc.
    Inventors: Tauseef R. Butt, Steven D. Weeks, Hiep T. Tran, Michael P. Malakhov, Oxana A. Malakhova
  • ISG15-conjugated proteins
    Publication number: 20050019847
    Abstract: The present invention provides methods to identify ISG15 target proteins, methods to identify compounds that alter the conjugation of ISG15 with target proteins, methods for altering the level of ISG15-conjugated protein in a patient or a sample, methods to diagnose a patient having a malcondition characterized by an altered level of ISG15-conjugated protein, ISG15-conjugates, methods to treat cancer by promoting conjugation of a target protein to ISG15, and antibodies that selectively bind to ISG15-conjugates.
    Type: Application
    Filed: February 3, 2004
    Publication date: January 27, 2005
    Inventors: Dong-Er Zhang, Mikhail Malakhov, Oxana Malakhova
  • Methods to identify agents that increase or decrease UBP43 activity and methods for use of such agents
    Publication number: 20040209315
    Abstract: The present invention is directed to identification of agents that modulate UBP43 activity as well as associated methods, uses, processes, compositions and agents. In particular, the invention is directed to in vivo and in vitro methods to identify an agent that inhibits or stimulates UBP43 activity within a cell, a method for inducing cellular apoptosis, a method for affecting cellular reaction to interferon, a method for treating disease associated with cellular proliferation by causing apoptosis, and a method for treating both acute and chronic diseases in which interferon exerts a beneficial effect. The invention is also directed to modified ISG15-conjugates that have lowered or no susceptibility to UBP43 cleavage, pharmaceutical compositions of the agents, conjugates, and additional modified ISG15-conjugates.
    Type: Application
    Filed: February 3, 2004
    Publication date: October 21, 2004
    Inventors: Dong-Er Zhang, Ming Yan, Oxana A. Malakhova
  • Methods and compositions for protein expression and purification
    Publication number: 20040018591
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Application
    Filed: March 14, 2003
    Publication date: January 29, 2004
    Inventors: Tauseef R. Butt, Stephen D. Weeks, Hiep T. Tran, Michael P. Malakhov, Oxana A. Malakhova
  • Methods and compositions for protein expression and purification
    Publication number: 20030153045
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Application
    Filed: January 7, 2003
    Publication date: August 14, 2003
    Inventors: Tauseef R. Butt, Steven D. Weeks, Hiep T. Tran, Michael P. Malakhov, Oxana A. Malakhova