Abstract: The present invention relates to a new inhibitor chemotype 3-(4-methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl) isoxazol-5-amine (BO-264) targeting TACC3 protein with high potency as a mitotic blocker for the treatment of breast and potentially other cancers.

Abstract: In one aspect, the present disclosure relates to compounds and compositions capable of inhibiting TACC3. In another aspect, the present disclosure relates to methods of treating TACC3 mediated diseases and disorders.

Abstract: The present disclosure relates to 3-(4-methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl) isoxazol-5-amine and methods of use thereof.

Abstract: An admixture including at least one copolymer having a backbone. The backbone including at least one electrically charged monomer. The at least one copolymer is a grafted copolymer having mean molecular weight within a range between 600 g/mol and 3000 g/mol on side chains of the grafted copolymer. An additive manufacturing ink, Filament of the additive manufacturing ink, and inkjet printing ink including the admixture.

Abstract: A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase, three-phase, four-phase, five-phase, or six-phase systems are disclosed. Using the disclosed multi-phase polymer systems, particles, or other analyte of interest can be separated based on their different densities or affinities.

Abstract: An admixture including at least one copolymer having a backbone. The backbone including at least one electrically charged monomer. The at least one copolymer is a grafted copolymer having mean molecular weight within a range between 600 g/mol and 3000 g/mol on side chains of the grafted copolymer. An additive manufacturing ink, Filament of the additive manufacturing ink, and inkjet printing ink including the admixture.

Abstract: The present invention proposes a polycarboxylate ether-based additive having the general formula (I) for use as flow modifier in suspensions. The present invention further proposes a method for obtainment of such additive, wherein the method comprises the sequential steps of esterification of polyethylene glycol (PEG) with maleic anhydride (MA) and thus obtainment of a chemical product (PEGMA); and free radical polymerization in a mixture comprising acrylic acid (AA), 2-acrylamido-2 methylpropanesulfonic acid (AMPS) and PEGMA as reactants, further comprising water and an initiator, initial pH value of said mixture is within the range between 7.5 and 8.5, and any free oxygen is removed from the mixture throughout the free radical polymerization.

Abstract: A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase, three-phase, four-phase, five-phase, or six-phase systems are disclosed. Using the disclosed multi-phase polymer systems, particles, or other analyte of interest can be separated based on their different densities or affinities.

Abstract: A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase, three-phase, four-phase, five-phase, or six-phase systems are disclosed. Using the disclosed multi-phase polymer systems, particles, or other analyte of interest can be separated based on their different densities or affinities.

Abstract: The present invention proposes a polyczuboxylate ether-based additive having the general formula (I) for use as flow modifier in suspensions. The present invention further proposes a method for obtainment of such additive, wherein the method comprises the sequential steps of esterification of polyethylene glycol (PEG) with maleic anhydride (MA) and thus obtainment of a chemical product (PEGMA) and free radical polymerization in a mixture comprising acrylic acid (AA), 2-acrylamido-2 methylpropanesulfonic acid (AMPS) and PEGMA as reactants, further comprising water and an initiator, initial pH value of said mixture is within the range between 7.5 and 8.5, and any free oxygen is removed from the mixture throughout the free radical polymerization.

Abstract: A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase, three-phase, four-phase, five-phase, or six-phase systems are disclosed. Using the disclosed multi-phase polymer systems, particles, or other analyte of interest can be separated based on their different densities or affinities.