Patents by Inventor Ozgur Sahin
Ozgur Sahin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240141878Abstract: Systems and methods for developing a composite material are disclosed. The system can include a plurality of particles and a plurality of polymers. The plurality of particles can generate mechanical force in response to changing relative humidity, and the plurality of filaments can transfer the mechanical force throughout the composite material, such that the mechanical force changes a shape of the composite material reversibly and repeatedly.Type: ApplicationFiled: November 2, 2023Publication date: May 2, 2024Applicant: THE TRUSTEES OF COLUMBIA UNIVRTSITY IN THE CITY OF NEW YORKInventors: Ozgur SAHIN, Eran SCHENKER, Yocheved UNGAR, Onur Cakmak
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Publication number: 20240075015Abstract: Described herein are compounds that block the activity of LOX family members having good IC50 values, no cellular toxicity below 10 ?M, induce sensitization of the cells to doxorubicin, strong activity in a recombinant LOX/LOXL2 activity, and a chemical structure that is drug-like and does not have a PAINS flag, as well as, methods of treatment using the compounds with respect to cancer, organ fibrosis, neurodegenerative and cardiovascular diseases.Type: ApplicationFiled: June 12, 2023Publication date: March 7, 2024Inventors: Ozgur Sahin, Campbell McInnes, Ozge Saatci, Chad Beneker, Abdol-Hossein Rezaeian, Metin Cetin
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Publication number: 20230243343Abstract: Water-responsive actuators and methods for creating water responsive actuators are disclosed. In some embodiments, the disclosed subject matter includes a first layer, for example a plastic tape, and a second layer, for example bacterial spores and cured adhesive. The second layer can be created in a pattern. The pattern can include joints, which can contract when exposed to dry air and can thereby bend the actuator, and can expand when exposed to humid air and thereby return the actuator its original position.Type: ApplicationFiled: February 10, 2023Publication date: August 3, 2023Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Ozgur SAHIN, Onur CAKMAK, Xi CHEN
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Patent number: 11712437Abstract: Described herein are novel compounds that block the activity of LOX family members having good IC50 values, no cellular toxicity below 10 ?M, induce sensitization of the cells to doxorubicin, strong activity in a recombinant LOX/LOXL2 activity, and a chemical structure that is drug-like and does not have a PAINS flag, as well as, methods of treatment using the compounds with respect to cancer, organ fibrosis, neurodegenerative and cardiovascular diseases.Type: GrantFiled: March 13, 2022Date of Patent: August 1, 2023Assignee: University of South CarolinaInventors: Ozgur Sahin, Campbell McInnes, Ozge Saatci, Chad Beneker, Abdol-Hossein Rezaeian, Metin Cetin
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Patent number: 11622966Abstract: The present invention relates to a new inhibitor chemotype 3-(4-methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl) isoxazol-5-amine (BO-264) targeting TACC3 protein with high potency as a mitotic blocker for the treatment of breast and potentially other cancers.Type: GrantFiled: March 14, 2019Date of Patent: April 11, 2023Assignees: A2A Pharmaceuticals, Inc., OncoCube Therapeutics LLCInventors: Erden Banoglu, Burcu Caliskan, Ozgur Sahin, Deniz Lengerli, Ozge Akbulut
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Patent number: 11603827Abstract: Water-responsive actuators and methods for creating water responsive actuators are disclosed. In some embodiments, the disclosed subject matter includes a first layer, for example a plastic tape, and a second layer, for example bacterial spores and cured adhesive. The second layer can be created in a pattern. The pattern can include joints, which can contract when exposed to dry air and can thereby bend the actuator, and can expand when exposed to humid air and thereby return the actuator its original position.Type: GrantFiled: May 10, 2019Date of Patent: March 14, 2023Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Ozgur Sahin, Onur Cakmak, Xi Chen
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Publication number: 20230058338Abstract: Water-responsive actuators and methods for creating water responsive actuators are disclosed. In some embodiments, the disclosed subject matter includes a first layer, for example a plastic tape, and a second layer, for example bacterial spores and cured adhesive. The second layer can be created in a pattern. The pattern can include joints, which can contract when exposed to dry air and can thereby bend the actuator, and can expand when exposed to humid air and thereby return the actuator its original position.Type: ApplicationFiled: May 10, 2019Publication date: February 23, 2023Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Ozgur Sahin, Onur Cakmak, Xi Chen
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Publication number: 20230027854Abstract: In one aspect, the present disclosure relates to compounds and compositions capable of inhibiting TACC3. In another aspect, the present disclosure relates to methods of treating TACC3 mediated diseases and disorders.Type: ApplicationFiled: November 13, 2020Publication date: January 26, 2023Inventors: Erden Banoglu, Burcu Caliskan, Ozgur Sahin, Deniz Lengerli, Ozge Akbulut, Chaemin Lim, Emmanuel Cruz, Sridhar Vempati, Kubra Ibis
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Publication number: 20220378753Abstract: Described herein are novel compounds that block the activity of LOX family members having good IC50 values, no cellular toxicity below 10 ?M, induce sensitization of the cells to doxorubicin, strong activity in a recombinant LOX/LOXL2 activity, and a chemical structure that is drug-like and does not have a PAINS flag, as well as, methods of treatment using the compounds with respect to cancer, organ fibrosis, neurodegenerative and cardiovascular diseases.Type: ApplicationFiled: March 13, 2022Publication date: December 1, 2022Applicant: University of South CarolinaInventors: Ozgur Sahin, Campbell Mclnnes, Ozge Saatci, Chad Beneker, Abdol-Hossein Rezaeian, Metin Cetin
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Patent number: 11156633Abstract: An AFM that suppress parasitic deflection signals is described. In particular, the AFM may use a cantilever with a probe tip that is offset along a lateral direction from a longitudinal axis of torsion of the cantilever. During AFM measurements, an actuator may vary a distance between the sample and the probe tip along a direction approximately perpendicular to a plane of the sample stage in an intermittent contact mode. Then, a measurement circuit may measure a lateral signal associated with a torsional mode of the cantilever during the AFM measurements. This lateral signal may correspond to a force between the sample and the probe tip. Moreover, a feedback circuit may maintain, relative to a threshold value: the force between the sample and the probe tip; and/or a deflection of the cantilever corresponding to the force. Next, the AFM may determine information about the sample based on the lateral signal.Type: GrantFiled: August 12, 2020Date of Patent: October 26, 2021Inventor: Ozgur Sahin
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Publication number: 20210220369Abstract: The present disclosure relates to 3-(4-methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl) isoxazol-5-amine and methods of use thereof.Type: ApplicationFiled: March 14, 2019Publication date: July 22, 2021Applicants: A2A Pharmaceuticals, Inc., OncoCube Therapeutics LLCInventors: Erden Banoglu, Burcu Caliskan, Ozgur Sahin, Deniz Lengerli, Ozge Akbulut
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Publication number: 20210197498Abstract: Systems and methods for developing a composite material are disclosed. The system can include a plurality of particles and a plurality of filaments. The plurality of particles can generate mechanical force in response to changing relative humidity, and the plurality of filaments can transfer the mechanical force throughout the composite material.Type: ApplicationFiled: February 26, 2021Publication date: July 1, 2021Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Ozgur SAHIN, Eran SCHENKER, Yocheved UNGAR, Onur CAKMAK
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Publication number: 20210030958Abstract: Aspects provide fluid responsive actuators and methods of using fluid responsive actuators capable of generating a power-to-volume ratio sufficient to inject a drug from a syringe within an injection period from about 1 to about 60 seconds after exposure of the fluid responsive elements to a fluid. The fluid responsive actuators can be used to inject viscous drugs to a patient.Type: ApplicationFiled: October 20, 2020Publication date: February 4, 2021Applicant: The Trustees of Columbia University in the City of New YorkInventor: Ozgur SAHIN
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Publication number: 20200371134Abstract: An AFM that suppress parasitic deflection signals is described. In particular, the AFM may use a cantilever with a probe tip that is offset along a lateral direction from a longitudinal axis of torsion of the cantilever. During AFM measurements, an actuator may vary a distance between the sample and the probe tip along a direction approximately perpendicular to a plane of the sample stage in an intermittent contact mode. Then, a measurement circuit may measure a lateral signal associated with a torsional mode of the cantilever during the AFM measurements. This lateral signal may correspond to a force between the sample and the probe tip. Moreover, a feedback circuit may maintain, relative to a threshold value: the force between the sample and the probe tip; and/or a deflection of the cantilever corresponding to the force. Next, the AFM may determine information about the sample based on the lateral signal.Type: ApplicationFiled: August 12, 2020Publication date: November 26, 2020Inventor: Ozgur Sahin
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Patent number: 10794930Abstract: An AFM that suppress parasitic deflection signals is described. In particular, the AFM may use a cantilever with a probe tip that is offset along a lateral direction from a longitudinal axis of torsion of the cantilever. During AFM measurements, an actuator may vary a distance between the sample and the probe tip along a direction approximately perpendicular to a plane of the sample stage in an intermittent contact mode. Then, a measurement circuit may measure a lateral signal associated with a torsional mode of the cantilever during the AFM measurements. This lateral signal may correspond to a force between the sample and the probe tip. Moreover, a feedback circuit may maintain, relative to a threshold value: the force between the sample and the probe tip; and/or a deflection of the cantilever corresponding to the force. Next, the AFM may determine information about the sample based on the lateral signal.Type: GrantFiled: January 26, 2017Date of Patent: October 6, 2020Inventor: Ozgur Sahin
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Publication number: 20190302105Abstract: A method of determining the structure of a molecule can include labeling a first location on the molecule with a first DNA strand, and measuring a force-time waveform using the twisting of a T-shaped atomic force microscope cantilever scanning across the molecule. The cantilever can include a DNA probe having a first region that is complimentary to the first DNA strand.Type: ApplicationFiled: November 15, 2018Publication date: October 3, 2019Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Ozgur Sahin, Duckhoe Kim
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Patent number: 10415550Abstract: Evaporation-driven engines are disclosed herein. An example engine can include a water source having a high humidity zone proximate the surface of the water source, a supporting structure, and a hygroscopic material disposed on the supporting structure and configured to generate mechanical force in response to a changing relative humidity. The hygroscopic material can be repeatedly exposed to the high humidity zone and removed from the high humidity zone thereby causing the hygroscopic material to generate mechanical force.Type: GrantFiled: May 8, 2015Date of Patent: September 17, 2019Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Xi Chen, Davis W. Goodnight, Ozgur Sahin
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Publication number: 20190178233Abstract: A method and system for providing an engine for producing mechanical energy through the absorption and evaporation of moisture uses a hygroscopic material in one or more configurations to do mechanical work. The hygroscopic material can include microbial spores, plant cells and cell materials, silk and hydrogel materials that absorb moisture and expand or swell when exposed to high relative humidity environments and shrink or return to nearly their original size or shape when exposed to low relative humidity environments wherein the moisture evaporates and is released. By exposing the hygroscopic material to a cycle of high relative humidity environments and low relative humidity environments, useful work can be done. One or more transmission elements can be used to couple the hygroscopic material to a generator that converts the mechanical energy to, for example, electrical energy.Type: ApplicationFiled: November 9, 2018Publication date: June 13, 2019Inventor: Ozgur SAHIN
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Publication number: 20190094265Abstract: An AFM that suppress parasitic deflection signals is described. In particular, the AFM may use a cantilever with a probe tip that is offset along a lateral direction from a longitudinal axis of torsion of the cantilever. During AFM measurements, an actuator may vary a distance between the sample and the probe tip along a direction approximately perpendicular to a plane of the sample stage in an intermittent contact mode. Then, a measurement circuit may measure a lateral signal associated with a torsional mode of the cantilever during the AFM measurements. This lateral signal may correspond to a force between the sample and the probe tip. Moreover, a feedback circuit may maintain, relative to a threshold value: the force between the sample and the probe tip; and/or a deflection of the cantilever corresponding to the force. Next, the AFM may determine information about the sample based on the lateral signal.Type: ApplicationFiled: January 26, 2017Publication date: March 28, 2019Inventor: Ozgur Sahin
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Patent number: 10151748Abstract: A method of determining the structure of a molecule can include labeling a first location on the molecule with a first DNA strand, and measuring a force-time waveform using the twisting of a T-shaped atomic force microscope cantilever scanning across the molecule. The cantilever can include a DNA probe having a first region that is complimentary to the first DNA strand.Type: GrantFiled: April 15, 2016Date of Patent: December 11, 2018Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Ozgur Sahin, Duckhoe Kim