Patents by Inventor P. D. J. Grootenhuis

P. D. J. Grootenhuis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thrombin inhibitors
    Publication number: 20020142967
    Abstract: The invention relates to non-slow-binding thrombin inhibitors of the formula: A—B—C-Lys-D— wherein A is H, 2-hydroxy-3-cyclohexyl-proprionyl-, R1, R1—O—CO—, R1—SO2—, —(CHR2)nCOOR3, or an N-protecting group, wherein R1 is selected from -(1-6C)alkylene-COOH, (1-12C)alkyl, (2-12C)alkenyl, (6-14C)aryl, (7-15C)aralkyl and (8-16C)aralkenyl, the aryl group of which may be substituted with (1-6C)alkyl, (2-12C)alkoxy, hydroxy, or halogen; R2 is H or has the same meaning as R1, R3 is selected from H, (1-12C)alkyl, (2-12C)alkenyl, (6-14C)aryl, (7-15C)aralkyl and (8-16C)aralkenyl, the aryl group of which may be substitute with (1-6C)alkyl, (2-12C)alkoxy, hydroxy or halogen; n is an integer of 1 to 3; B is a bond, L-asp or an ester derivative thereof, Leu, norLeu, —N(benzyl)-CH2—CO—, —N(2-indane)-CH2—CO—, D-1 Piq, D-3 Piq, D-Tiq, Atc or a D-amino acid having a hydrophobic aromatic side chain; C is Azt, Pro, Pec, norLeu(cyclo)Gly, an
    Type: Application
    Filed: January 4, 2002
    Publication date: October 3, 2002
    Inventors: A.E.P. Adang, C.A.A. van Boeckel, J.A.M. Peters, P.D.J. Grootenhuis
  • Thrombin inhibitors
    Patent number: 6432921
    Abstract: The invention relates to non-slow-binding thrombin inhibitors of the formula: A—B—C-Lys-D wherein A is H, 2-hydroxy-3-cyclohexylpropionyl-, R1, R1—O—CO—, R1—CO—, R1—SO2—, —(CHR2)nCOOR3, or an N-protecting group, wherein R1 is selected from —(1-6C)alkylene-COOH, (1-12C)alkyl, (2-12C)alkenyl, (6-14C)aryl, (7-15C)aralkyl; and (8-16C)aralkenyl, the aryl group of which may be substituted with (1-6C)alkyl, (2-12C)alkoxy, hydroxy, or halogen; R2 is H or has the same meaning as R1, R3 is selected from H, (1-12C)alkyl, (2-12C)alkenyl, (6-14C)aryl, (7-15C)aralkyl and (8-16C)aralkenyl, the aryl group of which may be substituted with (1-6C)alkyl, (2-12C)alkoxy, hydroxy or halogen; n is an integer of 1 to 3; B is a bond, L-Asp or an ester derivative thereof, Leu, norLeu, —N(benzyl)-CH2—CO—, —N(2-indane)-CH2—CO—, D-1-Piq, D-3-Piq, D-Tiq, Atc or a D-amino acid having a hydrophobic aromatic side chain; C is Azt, Pro, Pec, no
    Type: Grant
    Filed: May 3, 1998
    Date of Patent: August 13, 2002
    Assignee: Akzo Nobel N.V.
    Inventors: A. E. P. Adang, C. A. A. van Boeckel, J. A. M. Peters, P. D. J. Grootenhuis
  • THROMBIN INHIBITORS
    Publication number: 20010007764
    Abstract: The invention relates to non-slow-binding thrombin inhibitors of the formula: A-B-C-Lys-D wherein A is H, 2-hydroxy-3-cyclohexyl-propionyl-, R1, R1—O—CO—, R1—SO2—, —(CHR2)nCOOR3, or an N-protecting group, wherein R1 is selected from -(1-6C)alkylene-COOH, (1-12C)alkenyl, (6-14C)aryl, (7-15C)aralkyl and (8-16C)aralkenyl, the group of which may be substituted with (1-6C)alkyl, (2-12C)alkoxy, hydroxy, or halogen; R2 is H or has the same meaning as R1, R3 is selected from H, (112C)alkyl, (2-12C)alkenyl, (6-14C)aryl, (7-15C)aralkyl and (8-16C)aralkenyl, the aryl group of which may be substituted with (1-6C)alkyl, (2-12C)alkoxy, hydroxy or halogen; n is an integer of 1 to 3; B is a bond, L-Asp or an derivative thereof, Leu,norLeu, -n(benzyl)—CH2—CO—, -N(2-indane)—CH2—CO—, D-1Piq, D-Tiq, Atc or a D-amino acid having a hydrophobic aromatic side chain; C is Azt, Pro, Pec, norLeu(cyclo)Gly, an amino acid of one of the formulae -N[(3-8C)cycloalk
    Type: Application
    Filed: May 3, 1998
    Publication date: July 12, 2001
    Inventors: A.E.P. ADANG, C.A.A. VAN BOECKEL, J.A.M. PETERS, P.D.J. GROOTENHUIS