Patents by Inventor P. Dan Cook
P. Dan Cook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6828434Abstract: Novel amine compounds are provided by the present invention. Methods of preparing and using said novel amine compounds are also provided.Type: GrantFiled: July 10, 2002Date of Patent: December 7, 2004Assignee: ISIS Pharmaceuticals, Inc.Inventors: Muthiah Manoharan, P. Dan Cook
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Patent number: 6624294Abstract: Methods for the regioselective alkylation at the 2′-hydroxy position over the 3′-hydroxy position of nucleosides and nucleoside analogs, forming 2′-O-ester modified compounds, are disclosed. Reduction and derivatization of the 2′-O-ester provides 2′-O-modified nucleosides and nucleoside analogs useful for the synthesis of oligomeric compounds having improved hybridization affinity and nuclease resistance.Type: GrantFiled: April 16, 2002Date of Patent: September 23, 2003Assignee: ISIS Pharmaceuticals, Inc.Inventors: Andrew M. Kawasaki, Allister S. Fraser, Muthiah Manoharan, P. Dan Cook, Thazha P. Prakash
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Publication number: 20030153737Abstract: Novel amine compounds are provided by the present invention. Methods of preparing and using said novel amine compounds are also provided.Type: ApplicationFiled: July 10, 2002Publication date: August 14, 2003Applicant: ISIS Pharmaceuticals, Inc.Inventors: Muthiah Manoharan, P. Dan Cook
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Publication number: 20030078415Abstract: Methods for the regioselective alkylation at the 2′-hydroxy position over the 3′-hydroxy position of nucleosides and nucleoside analogs, forming 2′-O-ester modified compounds, are disclosed. Reduction and derivatization of the 2′-O-ester provides 2′-O-modified nucleosides and nucleoside analogs useful for the synthesis of oligomeric compounds having improved hybridization affinity and nuclease resistance.Type: ApplicationFiled: April 16, 2002Publication date: April 24, 2003Inventors: Andrew M. Kawasaki, Allister S. Fraser, Muthiah Manoharan, P. Dan Cook, Thazha P. Prakash
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Patent number: 6495671Abstract: Novel amine compounds are provided by the present invention. Methods of preparing and using said novel amine compounds are also provided.Type: GrantFiled: October 12, 2000Date of Patent: December 17, 2002Assignee: ISIS Pharmaceuticals, Inc.Inventors: Muthiah Manoharan, P. Dan Cook
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Patent number: 6403779Abstract: Methods for the regioselective alkylation at the 2′-hydroxy position over the 3′-hydroxy position of nucleosides and nucleoside analogs, forming 2′-O-ester modified compounds, are disclosed. Reduction and derivatization of the 2′-O-ester provides 2′-O-modified nucleosides and nucleoside analogs useful for the synthesis of oligomeric compounds having improved hybridization affinity and nuclease resistance.Type: GrantFiled: January 8, 1999Date of Patent: June 11, 2002Assignee: ISIS Pharmaceuticals, Inc.Inventors: Andrew M. Kawasaki, Allister S. Fraser, Muthiah Manoharan, P. Dan Cook, Thazha P. Prakash
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Patent number: 6399757Abstract: Novel amine compounds are provided by the present invention. Methods of preparing and using said novel amine compounds are also provided.Type: GrantFiled: October 12, 2000Date of Patent: June 4, 2002Assignee: ISIS Pharmaceuticals, Inc.Inventors: Muthiah Manoharan, P. Dan Cook
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Patent number: 6235886Abstract: Oligonucleotide and nucleotide amine analogs and methods of preparing and using these compounds are provided by the present invention.Type: GrantFiled: March 9, 1995Date of Patent: May 22, 2001Assignee: Isis Pharmaceuticals, Inc.Inventors: Muthiah Manoharan, P. Dan Cook
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Patent number: 6197965Abstract: Novel compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring system. Attached to the central ring system are two linear groups having nitrogenous moieties that are derivatized with chemical functional groups. The ring system can include further nitrogenous moieties, either as ring atoms or on pendant groups attached to the ring, that may also be derivatized with chemical functional groups. The totality of the chemical functional groups imparts certain conformational and other properties to the these compounds. In accordance with certain embodiments of the invention, libraries of such compounds are prepared utilizing permutations and combinations of the chemical functional groups and the nitrogenous moieties to build complexity into the libraries.Type: GrantFiled: May 17, 1999Date of Patent: March 6, 2001Assignee: ISIS Pharmaceuticals, Inc.Inventors: P. Dan Cook, Haoyun An
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Patent number: 6077954Abstract: Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring system. Attached to the central ring system are two linear groups having nitrogenous moieties that are derivatized with chemical functional groups. The ring system can include further nitrogenous moieties, either as ring atoms or on pendant groups attached to the ring, that may also be derivatized with chemical functional groups. The totality of the chemical functional groups imparts certain conformational and other properties to the these compounds. In accordance with certain embodiments of the invention, libraries of such compounds are prepared utilizing permutations and combinations of the chemical functional groups and the nitrogenous moieties to build complexity into the libraries.Type: GrantFiled: August 1, 1996Date of Patent: June 20, 2000Assignee: ISIS Pharmaceuticals, Inc.Inventors: P. Dan Cook, Haoyun An
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Patent number: 5948903Abstract: This invention relates to compounds based on the 3-deazapurines ring system and to methods for making such compounds. The invention also generally relates to the field of "antisense" agents, agents that are capable of specific hybridization with a nucleotide sequence of an RNA. The 3-deazapurine-containing compounds of this invention can be useful for modulating the activity of RNA when incorporated into oligonucleotides. Oligonucleotides and their analogs are used for a variety of therapeutic and diagnostic purposes, such as treating diseases, regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of antisense interactions with such RNA, diagnosing diseases, modulating the production of proteins and cleaving RNA in site specific fashions.Type: GrantFiled: May 8, 1998Date of Patent: September 7, 1999Assignee: ISIS Pharmaceuticals, Inc.Inventors: P. Dan Cook, Oscar L. Acevedo, Robert S. Andrews
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Patent number: 5834607Abstract: Novel amine compounds are provided by the present invention. Methods of preparing and using said novel amine compounds are also provided.Type: GrantFiled: December 22, 1994Date of Patent: November 10, 1998Assignee: ISIS Pharmaceuticals, Inc.Inventors: Muthiah Manoharan, P. Dan Cook
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Patent number: 5750692Abstract: This invention relates to compounds based on the 3-deazapurines ring system and to methods for making such compounds. The invention also generally relates to the field of "antisense" agents, agents that are capable of specific hybridization with a nucleotide sequence of an RNA. The 3-deazapurine-containing compounds of this invention can be useful for modulating the activity of RNA when incorporated into oligonucleotides. Oligonucleotides and their analogs are used for a variety of therapeutic and diagnostic purposes, such as treating diseases, regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of antisense interactions with such RNA, diagnosing diseases, modulating the production of proteins and cleaving RNA in site specific fashions.Type: GrantFiled: December 10, 1996Date of Patent: May 12, 1998Assignee: ISIS Pharmaceuticals, Inc.Inventors: P. Dan Cook, Oscar L. Acevedo, Robert S. Andrews
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Patent number: 5587470Abstract: This invention relates to compounds based on the 3-deazapurines ring system and to methods for making such compounds. The invention also generally relates to the field of "antisense" agents, agents that are capable of specific hybridization with a nucleotide sequence of an RNA. The 3- deazapurine-containing compounds of this invention can be useful for modulating the activity of RNA when incorporated into oligonucleotides. Oligonucleotides and their analogs are used for a variety of therapeutic and diagnostic purposes, such as treating diseases, regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of antisense interactions with such RNA, diagnosing diseases, modulating the production of proteins and cleaving RNA in site specific fashions.Type: GrantFiled: August 14, 1995Date of Patent: December 24, 1996Assignee: ISIS Pharmaceuticals, Inc.Inventors: P. Dan Cook, Oscar L. Acevedo, Robert S. Andrews
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Patent number: 5459255Abstract: This invention presents novel purine-based compounds for inclusion into oligonucleotides. The compounds of the invention, when incorporated into oligonucleotides are especially useful as agents that are capable of specific hybridization with a nucleotide sequence of an RNA. Oligonucleotides are used for a variety of purposes, such as regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of interactions with such RNA, diagnosing diseases, modulating the production of proteins, and cleaving RNA in site specific fashions. The compounds of the invention include novel heterocyclic bases, nucleosides, and nucleotides. When incorporated into oligonucleotides, the compounds of the invention can be useful for modulating the activity of RNA.Type: GrantFiled: November 29, 1993Date of Patent: October 17, 1995Assignee: Isis Pharmaceuticals, Inc.Inventors: P. Dan Cook, Kanda S. Ramasamy, Muthiah Manoharan
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Patent number: 5457191Abstract: This invention relates to compounds based on the 3-deazapurines ring system and to methods for making such compounds. The invention also generally relates to the field of "antisense" agents, agents that are capable of specific hybridization with a nucleotide sequence of an RNA. The 3-deazapurine-containing compounds of this invention can be useful for modulating the activity of RNA when incorporated into oligonucleotides. Oligonucleotides and their analogs are used for a variety of therapeutic and diagnostic purposes, such as treating diseases, regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of antisense interactions with such RNA, diagnosing diseases, modulating the production of proteins and cleaving RNA in site specific fashions.Type: GrantFiled: March 5, 1993Date of Patent: October 10, 1995Assignee: ISIS Pharmaceuticals, Inc.Inventors: P. Dan Cook, Oscar L. Acevedo, Robert S. Andrews
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Patent number: 4619996Abstract: A chemical process for preparing 2-.beta.-D-ribofuranosylselenazole-4-carboxamide, comprises reacting 2,3,5-tri-O-benzoyl-.beta.-D-ribofuranosyl-1-carbonitrile with gaseous hydrogen selenide in a polar organic solvent.Type: GrantFiled: July 9, 1984Date of Patent: October 28, 1986Assignee: Warner-Lambert CompanyInventors: P. Dan Cook, Dennis J. McNamara
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Patent number: 4439604Abstract: Hydroxy, amino and sulfhydryl derivatives of 7-.beta.-D-arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine, their corresponding esters and non-toxic pharmaceutically acceptable salts are produced by arabinofuranosylation of the requisite heterocycles with 2,3,5-tri-O-benzyl-.alpha.-D-arabinofuranosyl halide and further reaction to obtain the desired compounds. These water soluble compounds are resistant to adenosine deaminase and exhibit antiviral activity.Type: GrantFiled: June 24, 1982Date of Patent: March 27, 1984Assignee: Warner-Lambert CompanyInventor: P. Dan Cook
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Patent number: 4352795Abstract: Hydroxy, amino and sulfhydryl derivatives of 7-.beta.-D-arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine, their corresponding esters and non-toxic pharmaceutically acceptable salts are produced by arabinofuranosylation of the requisite heterocycles with 2,3,5-tri-O-benzyl-.alpha.-D-arabinofuranosyl halide and further reaction to obtain the desireexhibit antiviral activity.Type: GrantFiled: January 29, 1981Date of Patent: October 5, 1982Assignee: Warner-Lambert CompanyInventor: P. Dan Cook
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Patent number: 4315000Abstract: Hydroxy, amino and sulfhydryl derivatives of 1-.beta.-D-arabinofuranosyl-1H-imidazo[4,5-c]pyridine, their corresponding esters and non-toxic pharmaceutically acceptable salts are produced by arabinofuranosylation of the requisite heterocycles with 2,3,5-tri-O-benzyl-.alpha.-D-arabinofuranosyl halide and further reaction to obtain the desired compounds. These water soluble compounds are resistant to adenosine deaminase and exhibit antiviral activity.Type: GrantFiled: July 7, 1980Date of Patent: February 9, 1982Assignee: Warner-Lambert CompanyInventor: P. Dan Cook