Patents by Inventor P. Frederick Sparling

P. Frederick Sparling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transferrin-binding proteins from
    Patent number: 7582730
    Abstract: Iron-regulated, outer membrane proteins found in Neisseria gonorrhoeae and Neisseria meningitidis are important in transferrin receptor function. The proteins, which are isolatable by means of a transferrin affinity column, bind specifically to antisera raised against an iron-regulated outer membrane protein having a molecular weight of approximately 100 kD found in Neisseria gonorrhoeae.
    Type: Grant
    Filed: August 30, 2004
    Date of Patent: September 1, 2009
    Assignee: University of North Carolina at Chapel Hill
    Inventors: P. Frederick Sparling, Cynthia Nau Cornelissen
  • Antigenic iron repressible proteins from N. meningitidis related to the hemolysin family of toxins
    Patent number: 6887482
    Abstract: An isolated, antigenic polypeptide comprises a segment having at least fifty amino acid residues. The amino acid sequence of the segment is present in N. meningitidis, and is different from, but substantially homologous with, the amino acid sequence of a segment of a member of the hemolysin family of toxins.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: May 3, 2005
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: P. Frederick Sparling, Stuart Thompson
  • Antigenic iron repressible proteins from N. meningitidis related to the hemolysin family of toxins
    Publication number: 20030104002
    Abstract: An isolated, antigenic polypeptide comprises a segment having at least fifty amino acid residues. The amino acid sequence of the segment is present in N. meningitidis, and is different from, but substantially homologous with, the amino acid sequence of a segment of a member of the hemolysin family of toxins.
    Type: Application
    Filed: July 10, 2002
    Publication date: June 5, 2003
    Inventors: P. Frederick Sparling, Stuart Thompson
  • Isolated FrpB nucleic acid molecule and vaccine
    Publication number: 20030096368
    Abstract: The present invention provides an isolated nucleic acid molecule that encodes an amino acid sequence comprising a FrpB protein. The invention also provides vaccine compositions capable of protecting a mammal against infection by N. gonorrhoeae or N. meningitidis comprising the FrpB protein encoded by the isolated nucleic acid of the invention and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: March 8, 2001
    Publication date: May 22, 2003
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: P. Frederick Sparling, Margaret Beucher
  • DNA molecule encoding gonorrhoeal hybrid PIA/PIB protein
    Patent number: 6348332
    Abstract: The present invention relates to a gene sequence coding for hybrid Protein I of Neisseria gonorrhoeae, and cloning vector and host organisms containing same. Also disclosed are oligonucleotides useful as diagnostic probes for the detection of N. gonorrhoeae infection.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: February 19, 2002
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Nicholas H. Carbonetti, P. Frederick Sparling
  • Isolated FrpB nucleic acid molecule
    Patent number: 6265567
    Abstract: The present invention provides an isolated nucleic acid molecule that encodes an amino acid sequence comprising a FrpB protein. The invention also provides vaccine compositions capable of protecting a mammal against infection by N. gonorrhoeae or N. meningitidis comprising the FrpB protein encoded by the isolated nucleic acid of the invention and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: April 5, 1996
    Date of Patent: July 24, 2001
    Assignee: University of North Carolina at Chapel Hill
    Inventors: P. Frederick Sparling, Margaret Beucher
  • Antigenic iron repressible protein from N. meningitidis related to the hemolysin family of toxins
    Patent number: 6086896
    Abstract: An isolated, antigenic polypeptide comprises a segment having at least fifty amino acid residues. The amino acid sequence of the segment is present in N. meningitidis, and is different from, but substantially homologous with, the amino acid sequence of a segment of a member of the hemolysin family of toxins.
    Type: Grant
    Filed: October 14, 1994
    Date of Patent: July 11, 2000
    Assignee: ImClone Systems Incorporated
    Inventors: P. Frederick Sparling, Stuart Thompson
  • Production of gonorrheal PI proteins and vaccines
    Patent number: 6068992
    Abstract: The present invention relates to a gene sequence coding for Protein I of Neisseria gonorrhoeae, and cloning vector and host organisms containing same. Also disclosed are oligonucleotides useful as diagnostic probes for the detection of N. gonorrhoeae infection.
    Type: Grant
    Filed: November 6, 1997
    Date of Patent: May 30, 2000
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Nicholas H. Carbonetti, P. Frederick Sparling
  • Isolated nucleic acid molecules encoding transferrin binding proteins from Neisseria gonorrhoeae and Neisseria meningitidis
    Patent number: 5912336
    Abstract: Iron-regulated, outer membrane proteins found in Neisseria gonorrhoeae and Neisseria meningitidis are important in transferrin receptor function. The proteins, which are isolatable by means of a transferrin affinity column, bind specifically to antisera raised against an iron-regulated outer membrane protein having a molecular weight of approximately 100 kD found in Neisseria gonorrhoeae.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: June 15, 1999
    Assignee: University of North Carolina at Chapel Hill
    Inventors: P. Frederick Sparling, Cynthia Nau Cornelissen
  • Production of gonorrheal PI proteins
    Patent number: 5736361
    Abstract: The present invention relates to a gene sequence coding for Protein I of Neisseria gonorrhoea, and cloning vector and host organisms containing same. Also disclosed are oligonucleotides useful as diagnostic probes for the detection of N. gonorrhoea infection.
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: April 7, 1998
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Nicholas H. Carbonetti, P. Frederick Sparling