Abstract: A method for achieving a target joint preload can include applying a tightening torque to the second fastener element and measuring that torque as a trial tightening torque. The method can further include applying a loosening torque to the second fastener element and measuring that torque as a trial removal torque. Additionally, the method can include calculating a required tightening torque that is required to be applied to the second fastener element to achieve the target joint preload using only the thread pitch, the trial tightening torque, the trial removal torque, and the target joint preload.

Abstract: A method for achieving a target joint preload includes identifying a thread pitch of a first fastener element used to secure two components together. The first fastener element is passed through the two components and a second fastener element is threaded onto the first fastener element. A tightening torque is applied to the second fastener element, which is measured as the trial tightening torque. A loosening torque is applied to the second fastener element, which is measured as the trial removal torque. A required tightening torque that is required to be applied to the second fastener element to achieve the target joint preload is calculated using only the thread pitch, the trial tightening torque, the trial removal torque, and the target joint preload.

Abstract: Techniques for certificate authority (CA) selection are described. A certificate management service of a cloud provider network receives a first request to generate a certificate from an electronic device, the first request including an indication of an identity of a user and an identification of a domain name to associate with the certificate. A CA selection policy applicable to the first request is identified, the CA selection policy including a CA selection rule. A CA to generate the certificate is identified by evaluating the CA selection rule, the CA selection rule associates at least a portion of the domain name with the CA. A second request to generate the certificate is sent to the identified CA. The certificate or an identification of the certificate from the CA is returned to the electronic device.

Abstract: A set of consumers of a producer-consumer system includes a main consumer subset and a backstop consumer subset. A plurality of updates to message processing information are deployed to the set of consumers. Each update of the plurality of updates is first deployed to the backstop consumer sub-set and is subsequently deployed to the main consumer subset. The main consumer subset may obtain messages from producers and attempt to process the messages. By contrast, the backstop consumer subset may obtain messages only after a failed processing attempt by the main consumers. Upon obtaining a message, a main consumer may process the message successfully or may fail processing and provide the message for processing by a backstop consumer, which may be more up to date than the main consumer.

Abstract: Described herein is a first method of forming a hole in a workpiece, having a first surface and a second surface opposite the first surface. The method includes forming a first hole, having a first diameter, in the workpiece by passing a first cutter through the workpiece from the first surface to the second surface. Additionally, the method includes forming a chamfer in the second surface of the workpiece concentric with the first hole using a second cutter. The chamfer has a second diameter larger than the first diameter. The method further includes forming a second hole, having a third diameter larger than the first diameter, in the workpiece concentric with the first hole by passing a third cutter through the workpiece from the first surface to the second surface.

Abstract: A position guidance system for minimally invasive medical procedures includes a medical device having a first end configured for percutaneous insertion and a second end configured to remain exterior to a patient's skin, a hub connection provided at the second end of the medical device, at least one bubble level including a bubble configured to provide a visual indication of a deviation from a target angle for medical device insertion, and a connector configured to reversibly and repeatedly connect the bubble level to the hub connection of the medical device. When the bubble is positioned at a center of the bubble level, an actual insertion angle of the medical device is the same as the target angle. When the bubble is positioned off-center of the bubble level, the actual insertion angle of the medical device deviates from the target angle.

Abstract: Described herein is a first method of forming a hole in a workpiece, having a first surface and a second surface opposite the first surface. The method includes forming a first hole, having a first diameter, in the workpiece by passing a first cutter through the workpiece from the first surface to the second surface. Additionally, the method includes forming a chamfer in the second surface of the workpiece concentric with the first hole using a second cutter. The chamfer has a second diameter larger than the first diameter. The method further includes forming a second hole, having a third diameter larger than the first diameter, in the workpiece concentric with the first hole by passing a third cutter through the workpiece from the first surface to the second surface.

Abstract: A position guidance system for minimally invasive medical procedures includes a medical device having a first end configured for percutaneous insertion and a second end configured to remain exterior to a patient's skin, a hub connection provided at the second end of the medical device, at least one bubble level including a bubble configured to provide a visual indication of a deviation from a target angle for medical device insertion, and a connector configured to reversibly and repeatedly connect the bubble level to the hub connection of the medical device. When the bubble is positioned at a center of the bubble level, an actual insertion angle of the medical device is the same as the target angle. When the bubble is positioned off-center of the bubble level, the actual insertion angle of the medical device deviates from the target angle.

Abstract: The present invention relates to methods of treating or preventing drug poisoning and drug addiction in a subject. These methods involve administering to a subject in need of said treatment or prevention a ligand which binds to a regulatory site on the nicotinic acetylcholine receptor.

Abstract: Disclosed are various embodiments for discovery of public points of interest. Data identifying points of interest is obtained. Each point of interest is associated with a respective user and specifies a respective name and a respective geographic location. A public point of interest is determined based at least in part on a similarity of the respective names of a subset of the points of interest, a proximity of the respective geographic locations of the subset of the points of interest, and a number of different users associated with the subset of the points of interest.

Abstract: The present invention relates to methods of using cocaine-binding-site ligands and cocaine-binding-site RNA aptamers to treat or prevent Alzheimer's Disease and to reduce or prevent aggregation of beta-amyloid peptides in a subject.

Abstract: Disclosed is a method for modifying the frequency response of a wood panel within an acoustical structure such as a studio or concert hall. The modification is imparted by exciting the wood paneling with acoustic energy. Frequency response is the measure of a system's spectrum response at the output to a signal of varying frequency (but constant amplitude) at its input. The acoustic energy includes at least one excitation frequency, which is preferably in the audible spectrum (20 to 20,000 Hz). The use of acoustic energy from the remote source provides non-contact excitation of the wood paneling. In one embodiment, the acoustic energy is at least one sound wave which comprises at least one resonant frequency of the wood paneling, at least one acoustic mode of the wood paneling, at least one discrete broadband frequency, a composite frequency (including multiple broadband frequencies, white noise and pink noise) or any combination thereof.

Abstract: Disclosed are various embodiments for discovery of public points of interest. Data identifying points of interest is obtained. Each point of interest is associated with a respective user and specifies a respective name and a respective geographic location. A public point of interest is determined based at least in part on a similarity of the respective names of a subset of the points of interest, a proximity of the respective geographic locations of the subset of the points of interest, and a number of different users associated with the subset of the points of interest.

Abstract: The present invention relates to a photolabile compound including a coumarin family caging group covalently bound to an organic moiety containing a carboxyl group, an amino group, a sulfhydryl group, and/or a hydroxyl group. The photolabile compound, upon absorbing visible light, releases the organic moiety. Also disclosed is a method of making a photolabile compound that releases a biologically active compound upon absorbing visible light by providing an organic moiety and binding a coumarin family caging group to the organic moiety under conditions effective to make the photolabile compound. The present invention also relates to a method of obtaining a biologically active compound in a sample. The method involves adding to a sample a photolabile compound including a coumarin family caging group covalently bound to an organic moiety. The sample is then illuminated with visible light under conditions effective to obtain a biologically active compound including the organic moiety.

Abstract: Disclosed is a method for modifying the frequency response of a wooden article by exciting the article with acoustic energy. Frequency response is the measure of a system's spectrum response at the output due to a signal of varying frequency (but constant amplitude) at its input. The acoustic energy includes at least one excitation frequency, a composite broadband frequency component, or a combination thereof, which is preferably in the audible spectrum (20 to 20,000 Hz). The use of acoustic energy from the remote source provides non-contact excitation of the wooden article. In one embodiment, the acoustic energy is at least one sound wave which comprises at least one resonant frequency of the wooden article, at least one acoustic mode of the wooden article, at least one discrete frequency, a broadband frequency component, or any combination thereof.

Abstract: A method of artificially aging a musical instrument is provided by placing the instrument in an enclosure, providing at least one electromechanical transducer proximate to the instrument and providing an electrical signal to the transducer. The transducer is a three-way speaker in a preferred embodiment. The method has particular utility wherein the instrument is a wooden, stringed instrument.

Abstract: The present invention relates to methods of using cocaine-binding-site ligands and cocaine-binding-site RNA aptamers to treat or prevent Alzheimer's Disease and to reduce or prevent aggregation of beta-amyloid peptides in a subject.

Abstract: Disclosed is a method for modifying the frequency response of a wooden article by exciting the article with acoustic energy. Frequency response is the measure of a system's spectrum response at the output due to a signal of varying frequency (but constant amplitude) at its input. The acoustic energy includes at least one excitation frequency, a composite broadband frequency component, or a combination thereof, which is preferably in the audible spectrum (20 to 20,000 Hz). The use of acoustic energy from the remote source provides non-contact excitation of the wooden article. In one embodiment, the acoustic energy is at least one sound wave which comprises at least one resonant frequency of the wooden article, at least one acoustic mode of the wooden article, at least one discrete frequency, a broadband frequency component, or any combination thereof.

Abstract: A method of artificially aging a musical instrument is provided by placing the instrument in an enclosure, providing at least one electromechanical transducer proximate to the instrument and providing an electrical signal to the transducer. The transducer is a three-way speaker in a preferred embodiment. The method has particular utility wherein the instrument is a wooden, stringed instrument.