Patents by Inventor P. James Scrivens

P. James Scrivens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tyrosine hydroxylase variants and methods of use thereof
    Patent number: 10457918
    Abstract: The present disclosure provides a variant tyrosine hydroxylase that provides for increased production of L-DOPA in a host cell that expresses the tyrosine hydroxylase. The present disclosure provides nucleic acids encoding the variant tyrosine hydroxylase, and host cells genetically modified with the nucleic acids. The present disclosure provides methods of making L-DOPA in a host cell. The present disclosure provides methods of making a benzylisoquinoline alkaloid (BIA), or a BIA precursor. The present disclosure provides methods of detecting L-DOPA level in a cell. The present disclosure provides methods of identifying tyrosine hydroxylase variants that provide for increased L-DOPA production; and methods of identifying gene products that provide for increased tyrosine production.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: October 29, 2019
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, VALORBEC S.E.C.
    Inventors: Vincent J. J. Martin, Lauren Narcross, John E. Dueber, William C. DeLoache, Zachary N. Russ, P. James Scrivens
  • TYROSINE HYDROXYLASE VARIANTS AND METHODS OF USE THEREOF
    Publication number: 20170306301
    Abstract: The present disclosure provides a variant tyrosine hydroxylase that provides for increased production of L-DOPA in a host cell that expresses the tyrosine hydroxylase. The present disclosure provides nucleic acids encoding the variant tyrosine hydroxylase, and host cells genetically modified with the nucleic acids. The present disclosure provides methods of making L-DOPA in a host cell. The present disclosure provides methods of making a benzylisoquinoline alkaloid (BIA), or a BIA precursor. The present disclosure provides methods of detecting L-DOPA level in a cell. The present disclosure provides methods of identifying tyrosine hydroxylase variants that provide for increased L-DOPA production; and methods of identifying gene products that provide for increased tyrosine production.
    Type: Application
    Filed: September 24, 2015
    Publication date: October 26, 2017
    Applicant: The Regents of the University of California
    Inventors: Vincent J. J. Martin, Lauren Narcross, John E. Dueber, William C. DeLoache, Zachary N. Russ, P. James Scrivens