Patents by Inventor Pál Berzsenyi
Pál Berzsenyi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080269202Abstract: Disclosed are novel 2,3-benzodiazepine derivatives and methods of making the same.Type: ApplicationFiled: April 2, 2008Publication date: October 30, 2008Applicant: Teva Pharmaceutical Industries Ltd.Inventors: Emese Csuzdi, Sandor Solyom, Pal Berzsenyi, Ferenc Andrasi, Istvan Sziraki, Katalin Horvath, Zoltan Nagy
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Patent number: 6858605Abstract: The invention relates to new 2,3-benzodiazepine derivatives of formula (I), isomers and acid addition salts thereof and to pharmaceutical compositions containing the same, as well as to pharmaceutical compositions and methods of using the same suitable for treating conditions associated with muscle spasms, epilepsy, acute and chronic forms of neurodegenerative diseases as well as preventing, treating or alleviating the symptoms of acute and chronic inflammatory disorders.Type: GrantFiled: February 4, 2003Date of Patent: February 22, 2005Assignee: IVAX Drug Research Institute, Ltd.Inventors: Sándor Sólyom, Gizella Ábrahám, Tamás Hámori, Pál Berzsenyi, Ferenc Andrási, István Kurucz
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Publication number: 20040152693Abstract: The invention relates to new 2,3-benzodiazepine derivatives of formula (I), isomers and acid addition salts thereof and to pharmaceutical compositions containing the same, as well as to pharmaceutical compositions and methods of using the same suitable for treating conditions associated with muscle spasms, epilepsy, acute and chronic forms of neurodegenerative diseases as well as preventing, treating or alleviating the symptoms of acute and chronic inflammatory disorders.Type: ApplicationFiled: February 4, 2003Publication date: August 5, 2004Inventors: Sandor Solyom, Gizella Abraham, Tamas Hamori, Pal Berzsenyi, Ferenc Andrasi, Istvan Kurucz
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Patent number: 6602865Abstract: Pyridazino(4,5-b)(1,5)oxazepinone, thiazepinone and diazepinone compounds of formula(I) and their tautomers and the acid-addition salts of all these compounds show memory-enhancing and neuroprotective properties.Type: GrantFiled: November 15, 1999Date of Patent: August 5, 2003Assignee: IVAX Drug Research Institute, Ltd.Inventors: Ferenc Andrasi, Agnes Angyal nee Pataky, Pal Berzsenyi, Sandor Boros, Laszlo Harsing, Katalin Horvath, Peter Matyus, Imre Moravcsik, Agnes Papp nee Behr, Antal Simay, Erzsebet Szabo nee Bagdy, Katalin Szabo nee Pusztai, Istvan Tarnawa, Ildiko Varga
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Patent number: 6600036Abstract: Compounds of formula I are described, their production and use in pharmaceutical agents.Type: GrantFiled: November 27, 2001Date of Patent: July 29, 2003Assignee: Schering AktiengesellschaftInventors: Ernese Csuzdi, Tamas Hamori, Gizella Abraham, Sandor Solyom, Istvan Tarnawa, Pal Berzsenyi, Ferenc Andrasi, Istvan Ling, Antal Simay, Melinda Gal, Katalin Horvath, Eszter Szentkuti, Marta Szollosy, Istvan Pallagi
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Patent number: 6482819Abstract: 2,3-Benzodiazepines of formula (I), their stereoisomers and acid addition salts, wherein the variables have the meaning given in the specification, and pharmaceutical compositions containing them which are suitable for treating conditions associated with muscle spasms, epilepsy as well as acute and chronic forms of neurodegenerative diseases are disclosed.Type: GrantFiled: April 10, 2000Date of Patent: November 19, 2002Assignee: Gyogyszerkutato Intezet Kft.Inventors: Gizella Ábrahám, Emese Csuzdi, Sándor Sólyom, Pál Berzsenyi, István Tarnawa, Ferenc Andrási, István Ling, Tamás Hámori, Katalin Horváth, Imre Moravcsik, István Pallagi, Antal Simay
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Patent number: 6323197Abstract: The invention concerns compounds of formula (I), in which R1, R2, R3 and R4 mean hydrogen or different substituents; X means hydrogen or halogen; Y means C1-6 alkoxy or X and Y together mean —O—(CH2)n—O—; n means 1, 2 or 3; and A together with nitrogen forms a saturated or unsaturated five-member heterocycle which can contain between 1 and 3 nitrogen atoms and/or an oxygen atom and/or one or two carbonyl groups. Owing to their non-competitive inhibiting of the AMPA receptors, these compounds can be used as medicaments for treating diseases of the central nervous system.Type: GrantFiled: November 5, 1998Date of Patent: November 27, 2001Assignee: Schering AktiengesellschaftInventors: Ernese Csuzdi, Tamas Hámori, Gizella Ábrahám, Sändor Sólyom, István Tarnawa, Pál Berzsenyi, Ferenc Andrási, István Ling, Antal Simay, Melinda Gál, Katalin Horváth, Eszter Szentkuti, Márta Szöllosy, István Pallagi
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Patent number: 6265445Abstract: The present invention relates to novel, antiarrhythmically active phenoxyalkylamine derivatives possessing a double point of attack. More particularly, the present invention relates to new phenoxyalkylamine derivatives of the formula (1) wherein R1 and R2, independently from each other, mean hydrogen, halogen or C1-4 alkyl group; R3, R4 and R5, independently from each other, stand for hydrogen or C1-4 alkyl group; R6 represents hydrogen, C1-4 alkyl or benzyl group; R7 means nitro group or amino group optionally monosubstituted by C1-4 alkyl, benzoyl, C1-4 alkylcarbonyl, C1-4 alkylsulfonyl, C1-4 alkylcarbamoyl or C1-4 alkylthiocarbamoyl group; both n and m are 0 or 1, with the proviso that R2 is different from hydrogen, when R1 is hydrogen, as well as stereoisomers or mixtures of stereoisomers thereof, acid addition salts thereof and hydrates, prodrugs and metabolites of all these compounds.Type: GrantFiled: July 28, 2000Date of Patent: July 24, 2001Assignees: Gyogyszerkutato Intezet Kft, Szent-Gyorgyi Albert Orvostudomanyi EgyetemInventors: Gyula Papp, András Varró, Péter Mátyus, Ildikó Varga, Tivadar Rettegi, Alice Druga, Antal Simay, Imre Moravcsik, Pál Berzsenyi, Daniella Barlocco, Giorgio Cignarella, Márta Pátfalusi
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Patent number: 6200970Abstract: A compound of formula I in which X means hydrogen or halogen, Y means —NR3— or —N═, R1 and R2 are the same or different and mean hydrogen, C1-C6 alkyl, nitro, halogen, the group —NR8R9, —O—C1-4 alkyl, —CF3, OH or C1-6 alkanoyloxy, R3 means hydrogen, the group —CO—R10, C1-6 alkyl or C3-7 cycloalkyl, R4 means optionally substituted C1-C6 alkyl, R5 means hydrogen or R4 and R5 together mean oxygen, R6 means C1-4 alkyl, R8 and R9 are the same or different and mean hydrogen, C1-C6 alkyl or —CO—C1-6 alkyl, R10 means hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C6-10 aryl, the group —NR11R12, —O—C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or —O—C3-7 cycloalkyl, R11 and R12 are the same or different and mean hydrogen, optionally substituted C1-C6 alkyl or optionally substituted C6-10 aryl and —C...C...Type: GrantFiled: November 5, 1998Date of Patent: March 13, 2001Assignee: Schering AktiengesellschaftInventors: István Ling, Gizella Ábrahám, Sándor Sólyom, Tamás Hámori, István Tarnawa, Pál Berzsenyi, Ferenc Andrási, Emese Csuzdi, Márta Szöllósy, Antal Simay, István Lagi, Katalin Horváth
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Patent number: 6075018Abstract: The invention relates to new 1-[2-(substituted vinyl)]-3,4-dihydro-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof and pharmaceutical compositions comprising them. The new 1-[2-(substituted vinyl)]-3,4-dihidro-5H-2,3-benzodiazepine derivatives according to the invention correspond to the general formula (I), ##STR1## wherein the variables are hereinbelow defined: The new compounds according to the invention affect the central nervous system and can be used to advantage in the therapy.Type: GrantFiled: February 9, 1996Date of Patent: June 13, 2000Assignee: Egis Gyogyszergyar Rt.Inventors: Pal Vago, Jozsef Reiter, Istvan Gyertyan, Gabor Gigler, Ferenc Andrasi, Anna Bakonyi, Pal Berzsenyi, Peter Botka, deceased, Erszebet Birkas, Tamas Hamori, Edit Horvath, Katalin Horvath, Jeno Korosi, deceased, Gyorgyne Mate, Imre Moravcsik, Gyorgy Somogyi, Eszter Szentkuti, Gabor Zolyomi
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Patent number: 5942506Abstract: This invention relates to new 1-?2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said benzodiazepine derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The compounds according to the invention correspond to the general formula (I), ##STR1## wherein the variables are herein below defined, and the compounds possess central nervous activities.Type: GrantFiled: February 9, 1996Date of Patent: August 24, 1999Assignee: GIS Gyogyszergyar Rt.Inventors: Pal Vago, Jozsef Reiter, Istvan Gyertyan, Istvan Gacsalyi, Andras Bilkei-Gorzo, Andras Egyed, Ferenc Andrasi, Anna Bakonyi, Pal Berzsenyi, Hilda Botka, Tamas Hamori, Cecilia Salamon Haskane, Edit Horvath, Katalin Horvath, Peter Korosi, Gyorgyne Mate, Imre Moravcsik, Eszter Szentkuti, Gabor Zolyomi, Gabor Blasko, Klara Daroczi Kazone, Gyula Simig, Karoly Tihanyi, Judit Bajnogel
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Patent number: 5807851Abstract: Derivatives of 2,3-benzodiazepine are substituted by one or two halogen atom(s) and have the general formula ##STR1## These derivatives are non-competitive AMPA antagonists and are used in pharmaceutical compositions.Type: GrantFiled: April 4, 1997Date of Patent: September 15, 1998Assignee: Egis Gyogyszergyar Rt.Inventors: Istvan Ling, Gizella Abraham, Pal Berzsenyi, Istvan Tarnawa, Sandor Solyom, Ferenc Andrasi, Tamas Hamori, Emese Csuzdi, Katalin Horvath, Melinda Gal, Imre Moravcsik, Marta Szollosy
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Patent number: 5756495Abstract: New 3-substituted 3H-2,3-benzodiazepine derivatives of general formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and n have the meanings indicated in the description, their production as well as their use as pharmaceutical agents are described.Type: GrantFiled: January 31, 1997Date of Patent: May 26, 1998Assignee: Schering AktiengesellschaftInventors: Tamas Hamori, Istvan Tarnawa, Sandor Solyom, Pal Berzsenyi, Erzsebet Birkas, Ferenc Andrasi, Istvan Ling, Tibor Hasko, Gabor Kapus, Emese Csuzdl, Marta Szollosy, Franciska Erdo, Antal Simay, Gabor Zolyomi
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Patent number: 5639751Abstract: The invention relates to novel N-acyl-2,3-benzodiezapine derivatives of the general formula (I), their stereoisomers and acid-addition salts, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I)R stands for a C.sub.1-6 alkanoyl group optionally substituted by a methoxy, cyano, carboxyl, amino, C.sub.1-4 alkylamino, di(C.sub.1-4 alkyl)amino, pyrrolidino, phthalimido or phenyl group, or by one or more halogen(s); or R is a benzoyl, cyclopropanecarbonyl, C.sub.1-5 alkylcarbamoyl or phenylcarbamoyl group; or R is absent when a double bond exists between the N(3) and C(4) atoms;R.sup.1 means hydrogen; or R.sup.1 is absent when a double bond exists between the N(3) and C(4) atoms;R.sup.2 means a C.sub.1-3 alkyl group; orR.sup.1 and R.sup.2 together stand for a methylene group and no double bond is present between the N(3) and C(4) atoms;R.sup.3 means hydrogen or a C.sub.1-4 alkanoyl group;R.sup.4 represents hydrogen; a C.sub.Type: GrantFiled: June 7, 1995Date of Patent: June 17, 1997Assignee: Cyogyszerkutato Intezet KFTInventors: Ferenc Andrasi, Pal Berzsenyi, Peter Botka, Sandor Farkas, Katalin Goldschmidt, Tamas Hamori, Jeno Korosi, Imre Moravcsik, Istvan Tarnawa
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Patent number: 5536832Abstract: The invention relates to novel N-acyl-2,3-benzodiezapine derivatives of the general formula (I), their stereoisomers and acid-addition salts, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I)R stands for a C.sub.1-6 alkanoyl group optionally substituted by a methoxy, cyano, carboxyl, amino, C.sub.1-4 alkylamino, di(C.sub.1-4 alkyl)amino, pyrrolidino, phthalimido or phenyl group, or by one or more halogen(s); or R is a benzoyl, cyclopropanecarbonyl, C.sub.1-5 alkylcarbamoyl or phenylcarbamoyl group; or R is absent when a double bond exists between the N(3) and C(4) atoms;R.sup.1 means hydrogen; or R.sup.1 is absent when a double bond exists between the N(3) and C(4) atoms;R.sup.2 means a C.sub.1-3 alkyl group; orR.sup.1 and R.sup.2 together stand for a methylene group and no double bond is present between the N(3) and C(4) atoms;R.sup.3 means hydrogen or a C.sub.1-4 alkanoyl group;R.sup.4 represents hydrogen; a C.sub.Type: GrantFiled: April 17, 1995Date of Patent: July 16, 1996Assignee: Gyogyszerkutato Intezet KFTInventors: Ferenc Andrasi, Pal Berzsenyi, Peter Botka, Sandor Farkas, Katalin Goldschmidt, Tamas Hamori, Jeno Korosi, Imre Moravcsik, Istvan Tarnawa
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Patent number: 5521174Abstract: The invention relates to novel N-acyl-2,3-benzodiezapine derivatives and a method of treating spasms of the skeletal musculature therewith.Type: GrantFiled: June 7, 1995Date of Patent: May 28, 1996Assignee: Gyogyszerkutato Intezet Kv.Inventors: Ferenc Andrasi, Pal Berzsenyi, Peter Botka, Sandor Farkas, Katalin Goldschmidt, Tamas Hamori, Jeno Korosi, Imre Moravcsik, Istvan Tarnawa
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Patent number: 5519019Abstract: The invention relates to novel N-acyl-2,3-benzodiezapine derivatives of the general formula (I), their stereoisomers and acid-addition salts, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I)R stands for a C.sub.1-6 alkanoyl group optionally substituted by a methoxy, cyano, carboxyl, amino, C.sub.1-4 alkylamino, di(C.sub.1-4 alkyl)amino, pyrrolidino, phthalimido or phenyl group, or by one or more halogen(s); or R is a benzoyl, cyclopropanecarbonyl, C.sub.1-5 alkylcarbamoyl or phenylcarbamoyl group; or R is absent when a double bond exists between the N(3) and C(4) atoms;R.sup.1 means hydrogen; or R.sup.1 is absent when a double bond exists between the N(3) and C(4) atoms;R.sup.2 means a C.sub.1-3 alkyl group; orR.sup.1 and R.sup.2 together stand for a methylene group and no double bond is present between the N(3) and C(4) atoms;R.sup.3 means hydrogen or a C.sub.1-4 alkanoyl group;R.sup.4 represents hydrogen; a C.sub.Type: GrantFiled: June 7, 1995Date of Patent: May 21, 1996Assignee: Gyogyszerkutato IntezetInventors: Ferenc Andrasi, Pal Berzsenyi, Peter Botka, Sandor Farkas, Katalin Goldschmidt, Tamas Hamori, Jeno Korosi, Imre Moravcsik, Istvan Tarnawa
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Patent number: 5459137Abstract: The invention relates to novel N-acyl-2,3-benzodiezapine derivatives of the general formula (I), their stereoisomers and acid-addition salts, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I), defined in the specification, a more complete description of the compounds may be found.The compounds of the general formula (I) possess valuable central nervous system effects, particularly muscle-relaxant, anticonvulsive and neuroprotective action. Thus, they may be useful for the treatment of various diseases of central nervous system origin.Type: GrantFiled: June 21, 1993Date of Patent: October 17, 1995Assignee: Gyogyszerku-tato Intezet KftInventors: Ferenc Andrasi, Pal Berzsenyi, Peter Botka, Sandor Farkas, Katalin Goldschmidt, Tamas Hamori, Jeno Korosi, Imre Moravcsik, Istvan Tarnawa
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Patent number: 5037830Abstract: The present invention relates to novel compounds of the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 stand independently from each other, for hydrogen, C.sub.1-4 alkyl, phenyl, phenyl-C.sub.1-4 alkyl, piridyl or piridyl-C.sub.1-4 alkyl group;E means a straight or branched, saturated hydrocarbon chain containing 1 to 6 carbon atoms;R.sub.3 represents: a phenyl group ortho-substituted by a C.sub.2-5 alkanoylamino, N-C.sub.2-5 alkanoyl-N-C.sub.1-4 alkylamino or di(C.sub.1-4 alkyl)amino group and optionally further substituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.2-5 alkanoyloxy group; or a pyridyl group optionally mono- or polysubstituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.2-5 alkanoyloxy or phenyl-C.sub.1-4 alkoxy groupas well as their acid addition salts and tautomeric forms of these compounds.Type: GrantFiled: March 29, 1990Date of Patent: August 6, 1991Assignee: Richter Gedeon Vegyeszeti Gyar RTInventors: Gabor Zolyomi, Ferenc Andrasi, Pal Berzsenyi, Elemer Ezer, Tibor Hasko, Erzsebet F. Birkas, Erno Koltai, Judit Matuz, Lajos Toldy, Laszlo Sebestyen, Zsuzsanna Fittler, Katalin Saghy, Laszlo Szporny, Peter Aranyi
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Patent number: 4835152Abstract: The invention relates to new 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiaz epi ne of formula (1), optically active isomers and acid addition salts thereof as well as to pharmaceutical compositions containing these compounds. ##STR1## The new compounds of formula (I) can be prepared by reducing 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine of formula (II) with an inorganic or organic-inorganic and/or complex metal hydride and, if desired, separating the optically active forms of the compound of formula (I) thus-obtained and, if desired, converting the base or bases into acid addition salts or converting the salts into the free bases(s). ##STR2## The new compound of formula (I) possesses significant central nervous effects and can advantageously be used in the therapy.Type: GrantFiled: August 20, 1987Date of Patent: May 30, 1989Assignee: Biogal GyogyszergyarInventors: Jeno Korosi, Tibor Lang, Ferenc Andrasi, Pal Berzsenyi, Peter Botka, Tamas Hamori, Katalin G. Horvath, Jozsef Borsi, Istvan Elekes, Zsuzsanna L. Rihmer