Abstract: Methods for isolating patched genes, particularly mammalian patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated 15 physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like.

Abstract: A resilient mat system has at least one mat with a mat thickness T, an upper layer with an upper layer thickness t, and a plurality of supporting resilient substructure columns, each column having a relatively uniform height h, such that T=t+h, wherein the ratio of h:t>3.5 for values of T> about 0.9 inch. Each column wall surrounds a central void in the column, the void opening at a bottom of the column. The column has in a bottom region of the column wall a lower zone that is a more compressible, relatively collapsible zone, and in an upper region of the column wall above the lower zone an upper zone that is a less compressible, relatively uncollapsible zone. The resilient mat system optionally has a relatively rigid ramp structure bordering at least one mat on at least two sides, and the ramp structure is preferably attached to a floor base to retain the mat, whereby the mat is removable from the border of the ramp.

Abstract: Invertebrate and vertebrate patched genes are provided, including the mouse and human patched genes, as well as methods for isolation of related genes, where the genes may be of different species or in the same family. Having the ability to regulate the expression of the patched gene, allows for the elucidation of embryonic development, cellular regulation associated with signal transduction by the patched gene, the identification of agonist and antagonist to signal transduction, identification of ligands for binding to patched,isolation of the ligands, and assaying for levels of transcription and expression of the patched gene.

Abstract: A one-part adhesive composition for bonding glass including: (a) a cyanoacrylate monomer; (b) 15 to 60% w/w of at least one plasticizer by weight of the composition; (c) 0.01% to 5.0% w/w of at least one silane by weight of the composition.

Abstract: Invertebrate and vertebrate patched genes are provided, including the mouse and human patched genes, as well as methods for isolation of related genes, where the genes may be of different species or in the same family. Having the ability to regulate the expression of the patched gene, allows for the elucidation of embryonic development, cellular regulation associated with signal transduction by the patched gene, the identification of agonist and antagonist to signal transduction, identification of ligands for binding to patched, isolation of the ligands, and assaying for levels of transcription and expression of the patched gene.

Abstract: A phosphinimine catalyst for olefin polymerization is supported on a directly fluorided metal oxide with an aluminoxane. This catalyst is highly active for olefin polymerization in comparison to prior art catalysts which use non-fluorided metal oxide supports. The directly fluorided metal oxide may be conveniently prepared by contacting the precursor metal oxide with a simple alkali metal salt (such as NaF) in an aqueous slurry.

Abstract: A differential assembly including a rotatable casing, first and second axially moveable side gears disposed within the casing, at least one pinion gear disposed within the casing and intermeshed with the side gears, a cone clutch operatively coupled to the first side gear, the cone clutch being frictionally coupled to the casing in response to being exposed to a magnetic field, and a disc clutch having at least one clutch disc operatively coupled to the second side gear in response to axial movement of the second side gear.

Abstract: Novel compounds isolated from the bile of male sea lampreys are described, in particular, 7&agr;,12&agr;,24-trihydroxy-5&agr;-cholan-3-one-24-sulfate and 7&agr;,12&agr;-dihydroxy-5&agr;-cholan-3-one-24-oic acid and an ELISA for detecting the compounds. The bile compounds act as pheromones which attract female sea lampreys in water to the point in the water where the compounds had been introduced. The bile compounds are useful in lamprey population management programs where it is desirable to control the locomotion and distribution of lampreys and in food operations where it enhances the efficiency of catching lampreys for food.

Abstract: A supported catalyst for olefin polymerization comprises a combination of a novel metal oxide support and an activator which is an aluminoxane or a boron activator. The novel metal oxide support of this invention is a conventional particulate metal oxide support material (such as silica or alumina) which has been treated with a halosulfonic acid. A catalyst system which contains this novel catalyst support and a transition metal catalyst is highly active for olefin polymerization (in comparison to prior art catalyst systems which use a conventional metal oxide support).

Abstract: A supported catalyst for olefin polymerization comprises a combination of a sulfated metal oxide support, an aluminoxane and an organometallic complex of a group 4 metal. The sulfated metal oxide may be quickly and conveniently prepared by, for example, contacting the precursor metal oxide with a sulfuric acid. The supported catalyst of this invention is highly active for olefin polymerization in comparison to conventional catalysts which are prepared with non-sulfated supports.

Abstract: Methods for isolating patched genes, particularly mammalian patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated 15 physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like.

Abstract: A method of patterning a metal layer that cleans the residue from a metal etch process without removing a photoresist etch mask. The method is particularly useful for the fabrication of micromirror devices, or other MEMS devices that use photoresist spacer layers. A photoresist layer is spun on to the mirror metal layer in step 906. The photoresist is patterned and developed in step 908 to form openings to the metal layer. The openings define areas where the mirror metal layer will be removed. The patterned photoresist is inspected in step 910. The mirror metal layer is etched in step 912 using the patterned photoresist layer as an etch mask. After the mirror metal has been etched, the webbing and other residues are removed in a clean up process 914 that uses photoresist developer as a solvent to remove the webbing. After the developer clean up process, the mirrors are inspected in step 916 to verify the proper gaps have been etched between the mirrors and the removal of the mirror etch residue.

Abstract: This invention is method of recovering gas from a gas-bearing subterranean formation in which gas is produced from an upper portion of the formation and a waste gas is injected into a lower portion of the formation to dispose of the waste gas. The waste gas is injected within a 3000 foot (914 m) radial distance from the production of the gas. The injection and production can be carried out using one well or a plurality of wells.

Abstract: A bi-modal network connection device provides a high level of adaptability to changing connection-level loading patterns without sacrificing speed and configurability. The device can function in both a static mode and a traffic-adaptive mode. Benefits include the ability to provide high buffer utilization and throughput in ATM networks which either have very dynamic connection-level statistics or have poorly understood traffic characterization, plus the ability to assure users of minimal latency delays if desired.

Abstract: Invertebrate and vertebrate patched genes are provided, including the mouse and human patched genes, as well as methods for isolation of related genes, where the genes may be of different species or in the same family. Having the ability to regulate the expression of the patched gene, allows for the elucidation of embryonic development, cellular regulation associated with signal transduction by the patched gene, the identification of agonist and antagonist to signal transduction, identification of ligands for binding to patched, isolation of the ligands, and assaying for levels of transcription and expression of the patched gene.

Abstract: A multi-layer film includes a structural layer of water-soluble film, and a barrier layer. The barrier layer is affixed to spaced apart discrete areas of the structural layer. The barrier layer has insufficient structural integrity and strength to contain a bag's contents once the structural layer has been dissolved. A bag is formed by overlapping areas of the multi-layer film which do not include the barrier layer, and sealing the overlapping areas to one another.

Abstract: This invention provides improved methods of protein engineering, reagents useful therewith, and combinatorial libraries of chimeric proteins produced independent of amino acid or nucleotide sequence homology.

Abstract: The present invention is an apparatus for monocular head displays, which enables a compact, light in weight, sturdy apparatus that has a wide angle of viewing, a bright and sharp image display that operates on low voltage in a wide range of temperatures. The image is bright and high in contrast. Due to the compactiveness and wide viewing angle, it is readily useable inside helmets and goggles and visors. The signals that can be used include data, maps, graphics or video images including infrared or other images. Because of the wide viewing angle, the module may be placed and adjusted for multiple users and field installation.

Abstract: A bi-modal network connection device provides a high level of adaptability to changing connection-level loading patterns without sacrificing speed and configurability. The device can function in both a static mode and a traffic-adaptive mode. Benefits include the ability to provide high buffer utilization and throughput in ATM networks which either have very dynamic connection-level statistics or have poorly understood traffic characterization, plus the ability to assure users of minimal latency delays if desired.

Abstract: A differential assembly including a rotatable casing, first and second axially moveable side gears disposed within the casing, at least one pinion gear disposed within the casing and intermeshed with the side gears, a cone clutch operatively coupled to the first side gear, the cone clutch being frictionally coupled to the casing in response to being exposed to a magnetic field, and a disc clutch having at least one clutch disc operatively coupled to the second side gear in response to axial movement of the second side gear.