Patents by Inventor P. Sean Walsh

P. Sean Walsh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CLINICAL CLASSIFIERS AND GENOMIC CLASSIFIERS AND USES THEREOF
    Publication number: 20240071622
    Abstract: Provided herein are methods and systems for analyzing a sample of a subject to determine whether the subject has, or is at risk of having or developing, a cancer, such as lung cancer.
    Type: Application
    Filed: June 2, 2023
    Publication date: February 29, 2024
    Inventors: Giulia C. Kennedy, Yoonha Choi, Joshua Babiarz, Jianghan Qu, Daniel Pankratz, Shuyang Wu, Jie Ding, Sangeeta Bhorade, Lori Lofaro, P. Sean Walsh, Jing Huang
  • METHODS AND COMPOSITIONS THAT UTILIZE TRANSCRIPTOME SEQUENCING DATA IN MACHINE LEARNING-BASED CLASSIFICATION
    Publication number: 20180349548
    Abstract: Provided herein are methods and systems for producing a modified biological dataset by flagging or removing a nucleic acid sequence from the biological dataset that is assigned a noise-call to produce the modified biological dataset. The noise-call may be based on comparing a gene expression level, sequence information, or a combination thereof with a nucleic acid sequence of a control sample.
    Type: Application
    Filed: March 23, 2018
    Publication date: December 6, 2018
    Inventors: P. Sean Walsh, Giulia C. Kennedy, Kevin Travers, Zhanzhi Hu, Su Yeon Kim, Jing Huang
  • METHODS AND COMPOSITIONS FOR SAMPLE IDENTIFICATION
    Publication number: 20180068058
    Abstract: Compositions and methods are provided to provide an expression signature for a sample, where an alternative splicing index and profile are determined for the sample based on variations in the splicing of messenger RNA for at least one gene in the sample.
    Type: Application
    Filed: June 9, 2017
    Publication date: March 8, 2018
    Inventors: Diana ABDUEVA, Giulia C. KENNEDY, P. Sean WALSH
  • METHODS FOR ASSESSING THE RISK OF DISEASE OCCURRENCE OR RECURRENCE USING EXPRESSION LEVEL AND SEQUENCE VARIANT INFORMATION
    Publication number: 20180016642
    Abstract: Provided herein are methods, systems and kits for stratification of risk of disease occurrence of a sample obtained from a subject by combining two or more feature spaces to improve individualization of subject management.
    Type: Application
    Filed: September 1, 2017
    Publication date: January 18, 2018
    Inventors: Giulia C. KENNEDY, Moraima PAGAN, Chu-Fang LIN, Jing HUANG, P. Sean WALSH, Hajime MATSUZAKI, Kevin TRAVERS, Su Yeon KIM
  • METHODS AND COMPOSITIONS FOR CLASSIFICATION OF SAMPLES
    Publication number: 20160068915
    Abstract: Disclosed herein are kits, compositions, and methods relating to the classification of samples. Methods disclosed herein can also be used to diagnose conditions or to support treatment-related decisions.
    Type: Application
    Filed: September 11, 2015
    Publication date: March 10, 2016
    Inventors: Giulia C. Kennedy, Jonathan I. Wilde, Darya Chudova, Daniel Pankratz, Catalin Barbacioru, P. Sean Walsh, Moraima Pagan
  • Oligonucleotide probes specific for the human alpha satellite locus
    Patent number: 5464945
    Abstract: The present invention provides methods and reagents for the estimation of the quantity of human DNA contained in a sample. Immobilized sample DNA is hybridized to a biotinylated oligonucleotide probe that hybridizes to a human genomic or mitochondria DNA sequence. The subsequent binding of streptavidin-horseradish peroxidase to the bound probe allows for chemiluminescent detection using a luminol-based reagent and X-ray film. In addition, the present invention provides methods and reagents to assess the quality of DNA contained in a sample. The sample is first size fractionated by agarose gel electrophoresis, and then immobilized, hybridized to a biotinylated oligonucleotide probe, and detected using the chemiluminescent method as used in the quantity estimation methods of the present invention.
    Type: Grant
    Filed: August 28, 1992
    Date of Patent: November 7, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Rebecca L. Reynolds, P. Sean Walsh