Patents by Inventor Péter BUZDER-LANTOS
Péter BUZDER-LANTOS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11724979Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.Type: GrantFiled: July 15, 2021Date of Patent: August 15, 2023Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre Juhász, Irén Hortobágyi, Tamás Altsach, István Lászlófi, Ágnes Nagyné Borkó, Imre Rozsumberszki, Gábor Havasi, Zsuzsanna Kardos, Péter Buzder-Lantos
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Publication number: 20210340093Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.Type: ApplicationFiled: July 15, 2021Publication date: November 4, 2021Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre JUHÁSZ, Irén HORTOBÁGYI, Tamás ALTSACH, István LÁSZLÓFI, Ágnes NAGYNÉ BORKÓ, Imre ROZSUMBERSZKI, Gábor HAVASI, Zsuzsanna KARDOS, Péter BUZDER-LANTOS
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Patent number: 11098001Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.Type: GrantFiled: April 29, 2019Date of Patent: August 24, 2021Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre Juhász, Irén Hortobágyi, Tamás Altsach, István Lászlófi, Ágnes Nagyné Borkó, Imre Rozsumberszki, Gábor Havasi, Zsuzsanna Kardos, Péter Buzder-Lantos
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Patent number: 10501410Abstract: The subject of the invention is a process for the preparation of high purity prostaglandin acid of the general formula II wherein the bonds marked with dotted lines represent single or double bonds wherein the double bonds may be cis- or trans oriented, Y represents O or CH2, and R3 stands for a phenyl group which is optionally substituted with CF3, wherein the crude prostaglandin acid of the general formula II is purified by normal phase silicagel chromatography.Type: GrantFiled: March 11, 2015Date of Patent: December 10, 2019Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Ervin Vajda, Irén Hortobágyi, István Lászlofi, Péter Buzder-Lantos, Gábor Havasi, László Takács, Zsuzsanna Kardos
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Patent number: 10487051Abstract: The subject of the invention is a process for the preparation of Latanoprostene bunod of formula (I) with a purity higher than 95% where chromatography is used applying normal phase gravity silica gel column chromatography where the used silica gel is irregular silica gel or spherical silica gel an as eluent and eluent mixture consisting of an apolar and a polar solvent is used and if desired, contamination of the purified compound of formula I arising from the solvents are removed by silica gel filtration chromatography.Type: GrantFiled: November 11, 2016Date of Patent: November 26, 2019Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: László Takács, Ibolya Fekete, Péter Buzder-Lantos, István Lászlófi, Irén Hortobágyi, Gábor Havasi, Zsuzsanna Kardos
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Patent number: 10442762Abstract: The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are separated by gravity silica gel chromatography and the salt formation is carried out by using solid tromethamine base.Type: GrantFiled: November 10, 2016Date of Patent: October 15, 2019Assignee: CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA ZRT.Inventors: Péter Buzder-Lantos, Zsuzsanna Kardos, Irén Hortobágyi, István Lászlófi, Imre Juhász, László Fónagy, Csaba Váradi, Ágnes Nagyné Borkó
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Publication number: 20190248725Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.Type: ApplicationFiled: April 29, 2019Publication date: August 15, 2019Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre JUHÁSZ, Irén HORTOBÁGYI, Tamás ALTSACH, István LÁSZLÓFI, Ágnes NAGYNÉ BORKÓ, Imre ROZSUMBERSZKI, Gábor HAVASI, Zsuzsanna KARDOS, Péter BUZDER-LANTOS
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Patent number: 10322990Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.Type: GrantFiled: September 28, 2015Date of Patent: June 18, 2019Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre Juhász, Irén Hortobágyi, Tamás Altsach, István Lászlófi, Ágnes Nagyné Borkó, Imre Rozsumberszki, Gábor Havasi, Zsuzsanna Kardos, Péter Buzder-Lantos
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Publication number: 20190002405Abstract: The subject of the invention is a process for the preparation of Latanoprostene bunod of formula (I) with a purity higher than 95% where chromatography is used applying normal phase gravity silica gel column chromatography where the used silica gel is irregular silica gel or spherical silica gel an as eluent and eluent mixture consisting of an apolar and a polar solvent is used and if desired, contamination of the purified compound of formula I arising from the solvents are removed by silica gel filtration chromatography.Type: ApplicationFiled: November 11, 2016Publication date: January 3, 2019Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT .Inventors: László TAKÁCS, Ibolya FEKETE, Péter BUZDER-LANTOS, István LÁSZLÓFI, Irén HORTOBÁGYI, Gábor HAVASI, Zsuzsanna KARDOS
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Publication number: 20180362457Abstract: The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are separated by gravity silicagel chromatography and the salt formation is carried out by using solid tromethamine base.Type: ApplicationFiled: November 10, 2016Publication date: December 20, 2018Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT .Inventors: Péter BUZDER-LANTOS, Zsuzsanna KARDOS, Irén HORTOBÁGYI, István LÁSZLÓFI, Imre JUHÁSZ, László FÓNAGY, Csaba VÁRADI, Ágnes NAGYNÉ BORKÓ
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Publication number: 20170313643Abstract: The invention provides a new process for the preparation of treprostinil of formula (I) and its salts using several new intermediates during the building of the ring system.Type: ApplicationFiled: September 28, 2015Publication date: November 2, 2017Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre JUHÁSZ, Irén HORTOBÁGYI, Tamás ALTSACH, István LÁSZLÓFI, Ágnes NAGYNÉ BORKÓ, Imre ROZSUMBERSZKI, Gábor HAVASI, Zsuzsanna KARDOS, Péter BUZDER-LANTOS
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Publication number: 20170037002Abstract: The subject of the invention is a process for the preparation of high purity prostaglandin acid of the general formula II wherein the bonds marked with dotted lines represent single or double bonds wherein the double bonds may be cis- or trans oriented, Y represents 0 or CH2, and R3 stands for a phenyl group which is optionally substituted with CF3, wherein the crude prostaglandin acid of the general formula II is purified by normal phase silicagel chromatography.Type: ApplicationFiled: March 11, 2015Publication date: February 9, 2017Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Ervin VAJDA, Irén HORTOBÁGYI, István LÁSZLOFI, Péter BUZDER-LANTOS, Gábor HAVASI, László TAKÁCS, Zsuzsanna KARDOS
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Patent number: 9447038Abstract: The present invention relates to compounds of formula 1 that are useful for the preventive and/or therapeutic treatment of diseases caused by abnormal activation of CXCR3 chemokines. The invention relates furthermore to a process for the preparation of said compounds, to pharmaceutical compositions containing said compounds and to novel intermediates used in the preparation of said compounds.Type: GrantFiled: November 18, 2014Date of Patent: September 20, 2016Assignee: SanofiInventors: Imre Bata, Veronika Bartane Bodor, Attila Vasas, Peter Buzder-Lantos, Gyorgy Ferenczy, Zsuzsanna Tomoskozi, Gabor Szeleczky, Zsuzsanna Szamosvolgyi
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Patent number: 9073853Abstract: The present invention relates to compounds of formula 1 that are useful for the preventive or therapeutic treatment of diseases caused by abnormal activation of CXCR3 chemokines. The invention relates furthermore to a process for the preparation of said compounds, to pharmaceutical compositions containing said compounds and to novel intermediates used in the preparation of said compounds.Type: GrantFiled: June 3, 2014Date of Patent: July 7, 2015Assignee: SANOFIInventors: Imre Bata, Peter Buzder-Lantos, Attila Vasas, Veronika Bartane Bodor, Gyorgy Ferenczy, Zsuzsanna Tomoskozi, Gabor Szeleczky, Sandor Batori, Martin Smrcina, Marcel Patek, Aleksandra Weichsel, David Squire Thorpe
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Publication number: 20150073004Abstract: The present invention relates to compounds of formula 1 that are useful for the preventive and/or therapeutic treatment of diseases caused by abnormal activation of CXCR3 chemokines. The invention relates furthermore to a process for the preparation of said compounds, to pharmaceutical compositions containing said compounds and to novel intermediates used in the preparation of said compounds.Type: ApplicationFiled: November 18, 2014Publication date: March 12, 2015Inventors: Imre BATA, Veronika BARTONE BODOR, Attila VASAS, Peter BUZDER-LANTOS, Gyorgy FERENCZY, Zsuzsanna TOMOSKOZI, Gabor SZELECZKY, Zsuzsanna SZAMOSVOLGYI
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Publication number: 20140288106Abstract: The present invention relates to compounds of formula 1 that are useful for the preventive or therapeutic treatment of diseases caused by abnormal activation of CXCR3 chemokines. The invention relates furthermore to a process for the preparation of said compounds, to pharmaceutical compositions containing said compounds and to novel intermediates used in the preparation of said compounds.Type: ApplicationFiled: June 3, 2014Publication date: September 25, 2014Applicant: SanofiInventors: Imre BATA, Peter BUZDER-LANTOS, Attila VASAS, Veronika BARTANE BODOR, Gyorgy FERENCZY, Zsuzsanna TOMOSKOZI, Gabor SZELECZKY, Sandor BATORI, Martin SMRCINA, Marcel PATEK, Aleksandra WEICHSEL, David Squire Thorpe