Abstract: In an aspect, disclosed herein are physiological devices and systems, and components thereof, used to evaluate cardiac parameters and arrhythmogenic mechanisms. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A hand-held power tool, in particular an angle grinder, includes a tool housing that includes a handle casing for holding the power tool as well as a drive casing, in particular arranged on the handle casing, for accommodating a drive unit operable in particular by means of a rechargeable battery unit. The drive unit has an input shaft, which is in particular mounted to be rotatable about an input axis, and an output shaft, which is in particular mounted to be rotatable about an output axis.

Abstract: A safety operating device for operating a machine tool, in particular a hand-held machine tool, is disclosed. The device includes at least one operating unit, in particular a dead-man unit, for actuating the machine tool. The operating unit is designed to be moved in a sequence of at least two mutually different actuating movements. The device further includes a pre-activation unit that is designed to enable activation of the machine tool by way of an actuation by the operating unit.

Abstract: In an aspect, disclosed herein are physiological devices and systems, and components thereof, used to evaluate cardiac parameters and arrhythmogenic mechanisms. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: In an aspect, disclosed herein are physiological devices and systems, and components thereof, used to evaluate cardiac parameters and arrhythmogenic mechanisms. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A method is disclosed for moving a robot arm for an ultrasound examination, an ultrasound probe being attached to the robot arm. An associated ultrasound system is also disclosed. In an embodiment, the method includes providing a trained artificial neural network recording a medical issue; determining a motion dataset containing a motion sequence of the robot arm by applying the trained artificial neural network to the medical issue; transferring the motion dataset to a controller of the robot arm; and moving the robot arm in accordance with the motion sequence of the motion dataset. An associated second computing unit, and an associated computer program product are also disclosed.

Abstract: A method is disclosed for moving a robot arm for an ultrasound examination, an ultrasound probe being attached to the robot arm. An associated ultrasound system is also disclosed. In an embodiment, the method includes providing a trained artificial neural network recording a medical issue; determining a motion dataset containing a motion sequence of the robot arm by applying the trained artificial neural network to the medical issue; transferring the motion dataset to a controller of the robot arm; and moving the robot arm in accordance with the motion sequence of the motion dataset. An associated second computing unit, and an associated computer program product are also disclosed.

Abstract: The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.

Abstract: The invention provides a culture of patterned cardiomyocytes, the culture including a support substrate bearing a multielectrode array, a negative surface resistant to cell attachment and deposited on the support substrate covering the multi-electrode array, a pattern ablated on the negative surface, a positive surface promoting cell attachment deposited on the pattern ablated on the negative surface; and cardiomyocytes adherent to the positive surface and growing aligned along the pattern ablated on the negative surface. The invention also includes a method of making the culture of patterned cardiomyocytes and a method of in vitro method of testing the effect of a compound on cardiac function by measuring electrical output from the patterned cardiomyocytes.

Abstract: The invention provides a culture of patterned cardiomyocytes, the culture including a support substrate bearing a multielectrode array, a negative surface resistant to cell attachment and deposited on the support substrate covering the multi-electrode array, a pattern ablated on the negative surface, a positive surface promoting cell attachment deposited on the pattern ablated on the negative surface; and cardiomyocytes adherent to the positive surface and growing aligned along the pattern ablated on the negative surface. The invention also includes a method of making the culture of patterned cardiomyocytes and a method of in vitro method of testing the effect of a compound on cardiac function by measuring electrical output from the patterned cardiomyocytes.

Abstract: In an aspect, disclosed herein are physiological devices and systems, and components thereof, used to evaluate cardiac parameters and arrhythmogenic mechanisms. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A method and apparatus to enable data integrity checking of a block of data while the block of data is being transferred from a volatile memory to a non-volatile storage device is provided. The data integrity checking is performed in conjunction with Direct Memory Access operations and Redundant Array of Independent Disk (RAID) operations. In addition, data integrity checking of syndrome blocks in the RAID is performed during transfers to/from the storage devices in the RAID system and during RAID update and RAID data reconstruction operations.

Abstract: The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.

Abstract: A method and apparatus to enable data integrity checking of a block of data while the block of data is being transferred from a volatile memory to a non-volatile storage device is provided. The data integrity checking is performed in conjunction with Direct Memory Access operations and Redundant Array of Independent Disk (RAID) operations. In addition, data integrity checking of syndrome blocks in the RAID is performed during transfers to/from the storage devices in the RAID system and during RAID update and RAID data reconstruction operations.

Abstract: A method of screening a compound for effectiveness in treating amyloid beta neurotoxicity comprises culturing mammalian neurons in serum-free defined medium until the neurons are electrically functional, exposing the electrically stable neurons to amyloid beta, monitoring the exposed neurons for impairment of electrical functionality, and treating the exposed neurons with the candidate drug while monitoring their electrical activity for reversal of impairment.

Abstract: An automotive cleaning compound for a plastic lens having a cleaning compound, hydrocarbons, water, ammonia, stabilizing material, and waxy material.

Abstract: A communication system is dynamically configured to use some or all of the communication channel bandwidth. Regions of the communication channel are prioritized, and bandwidth is allocated in accordance with priorities and requested data rate.

Abstract: The subject of the invention is method and device system for entering and retrieving information in the surface layer of objects made of solid matters. The information is entered with a (concentrated) beam directed to the surface and having a power density selected to induce permanent change at least in the surface layer of the material's structure in a way that the power density of the beam is smaller that the power density of the beam causing visible deformation, but bigger than that of the beam that causes (within the order of magnitude of the beam's diameter) inhomogeneities commensurable with the structural inhomogeneities generally present in the material. The invention can be used for all materials, the structure or internal stress of which can be modified with high energy density surface treatment (at the location of the treatment) (specially with the local laser treatment of ferromagnetic material).

Abstract: The present invention relates to new prolylendopeptidase inhibitors of general formula (I).

Abstract: A method for determining the longitudinal loading acting on a beam, such as a rail of a railway track subjected to longitudinal loading and, in particular, for determining the neutral temperature of railway tracks. The beam is energized longitudinally in the acoustic frequency range, and the level of magnetic Barkhausen noise at the surface of the energized region is measured. Measurements of the magnetic Barkhausen noise are taken for different longitudinal stress states and used for plotting the calibration curve of the magnetic Barkhausen noise as a function of longitudinal stress, the Barkhausen noise being measured at least at three points on the face of the built-in beam, and the calibration curve is used for determining the longitudinal loading on the cross-section in question using weighted averaging. The neutral temperature of the railway track is then calculated considering the modulus of elasticity, coefficient of thermal expansion and temperature of the rail.