Abstract: Apparatus and a concomitant method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate.

Abstract: In one aspect, the present invention provides an inhaler apparatus comprising interior surfaces having contact with a medicament for inhalation, the interior surfaces including an interior surface of a mouthpiece and a substrate with medicament deposited thereon, at least one of such interior surfaces comprising indentations or raised areas therein, the raised areas having valleys therebetween. In certain preferred embodiments, the interior surface is a surface on a substrate having medicament deposited thereon, and in other preferred embodiments, the interior surface is an interior surface of the mouthpiece of the inhaler. In addition to providing surface topology for minimizing the area of contact between the medicament and the surfaces of the inhaler, the surfaces are preferably made of a material having a low surface energy, and more preferably, also having, when uncharged, no substantial van der Waals or electrostatic interaction with the medicament.

Abstract: Apparatus and a concomitant method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate.

Abstract: In accordance with the present invention, a method of electrophotographically manufacturing a luminescent screen assembly on an interior surface of a faceplate panel 17 of a color CRT 10 includes the steps of: coating the surface of the panel with a conductive solution to form a volatilizable organic conductive layer 32, and overcoating the organic conductive layer 32 with a photoconductive solution to form a volatilizable photoconductive layer 34. The conductive solution comprises the organic polymer 3,4-polyethylene dioxythiophene polystyrene sulphonate (PEDT/PSS); a methanol-soluble polymer or co-polymer selected from the group consisting of polyvinylpyrrolidone (PVP), poly (vinyl pyridine-co-vinyl acetate) (PVPy-VAc), polymethacrylic acid (PMAA), poly (hydroxyethylacrylate-co-methacrylic acid) (PHEA-MAA) and poly (hydroxyethyl methacrylate) (PHEMA) to reduce organic residue; and a solvent.

Abstract: A method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, an apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate.

Abstract: In one aspect, the present invention provides an inhaler apparatus comprising interior surfaces having contact with a medicament for inhalation, the interior surfaces including an interior surface of a mouthpiece and a substrate with medicament deposited thereon, at least one of such interior surfaces comprising indentations or raised areas therein, the raised areas having valleys therebetween. In certain preferred embodiments, the interior surface is a surface on a substrate having medicament deposited thereon, and in other preferred embodiments, the interior surface is an interior surface of the mouthpiece of the inhaler. In addition to providing surface topology for minimizing the area of contact between the medicament and the surfaces of the inhaler, the surfaces are preferably made of a material having a low surface energy, and more preferably, also having, when uncharged, no substantial van der Waals or electrostatic interaction with the medicament.

Abstract: In one aspect, the present invention provides an inhaler apparatus comprising interior surfaces having contact with a medicament for inhalation, the interior surfaces including an interior surface of a mouthpiece and a substrate with medicament deposited thereon, at least one of such interior surfaces comprising indentations or raised areas therein, the raised areas having valleys therebetween. In certain preferred embodiments, the interior surface is a surface on a substrate having medicament deposited thereon, and in other preferred embodiments, the interior surface is an interior surface of the mouthpiece of the inhaler. In addition to providing surface topology for minimizing the area of contact between the medicament and the surfaces of the inhaler, the surfaces are preferably made of a material having a low surface energy, and more preferably, also having, when uncharged, no substantial van der Waals or electrostatic interaction with the medicament.

Abstract: Method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate.

Abstract: A light-absorbing matrix 23, having openings therein, is formed on an interior surface of a faceplate panel 12 of a cathode-ray tube 10 by providing a photoreceptor thereon, electrostatically charging the photoreceptor 72 to a substantially uniform level of charge, and exposing the photoreceptor to light through openings 33 in a color selection electrode 24 to selectively discharge the more intensely illuminated areas of the photoreceptor, without substantially discharging the less intensely illuminated areas. The photoreceptor 72 comprises a plurality of layers including a photoresist layer 56, a conductive layer 62, and a photoconductive layer 66. The openings 33 in the color selection electrode 24 have a dimension substantially greater than the dimension of the openings in the resultant matrix 23.The photoreceptor 72 is contacted with a liquid toner having charged pigment particles which form toner lines 84 on the less intensely illuminated areas of the photoreceptor.

Abstract: Apparatus and a concomitant method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate.

Abstract: In one aspect, the present invention provides an inhaler apparatus comprising interior surfaces having contact with a medicament for inhalation, the interior surfaces including an interior surface of a mouthpiece and a substrate with medicament deposited thereon at least one of such interior surfaces comprising indentations or raised areas therein, the raised areas having valleys therebetween. In certain preferred embodiments, the interior surface is a surface on a substrate having medicament deposited thereon, and in other preferred embodiments, the interior surface is an interior surface of the mouthpiece of the inhaler. In addition to providing surface topology for minimizing the area of contact between the medicament and the surfaces of the inhaler, the surfaces are preferably made of a material having a low surface energy, and more preferably, also having, when uncharged, no substantial van der Waals or electrostatic interaction with the medicament.

Abstract: The present invention is directed, in part, to an inhaler apparatus with a substrate having medicament deposited thereon, the substrate being configured for electronic release of the medicament. In preferred embodiments, the inhaler comprises a conductive layer and a dielectric layer thereon. In preferred embodiments, the inhaler further comprises a second conductive layer positioned above the substrate without having contact with the substrate. In certain preferred embodiments, the voltage source is connected to the conductive layer in the substrate and the second conductive layer above the substrate.

Abstract: The present invention provides an acoustic dispenser for propelling objects toward a substrate, together with methods of use of the dispenser. The acoustic dispenser uses a source of acoustic vibration and a membrane for the application of acoustic vibration wherein the objects are propelled from the membrane to a substrate. The acoustic dispenser and the methods of the invention can be used with numerous types of objects. In some embodiments, the objects are particles in a dry powder, which can include, for example, a pharmaceutically active ingredient. In other embodiments, the objects are beads, which preferably have an average diameter of about 100 to about 300 microns. Additionally, the acoustic dispenser can be used with more than one type of object, for example, two types of objects such as beads and dry powder.

Abstract: Apparatus and a concomitant method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate.

Abstract: A tribo-inhaler having a container portion for electrostatically retaining a predefined dose of medicament powder, where the medicament is tribo-electrically charged; and apparatus, attached to the container portion, for extracting said medicament powder from the container portion. The container portion contains a plurality of polymeric beads that have diameters of approximately 50 to 200 microns. Each of the polymeric beads has a specific quantity of dry powder medicament electrostatically adhered to its surface. To remove the medicament from the cavity, a patient merely inhales air through the container portion. The air flow forcefully moves the beads within the container portion causing the medicament to dislodge from the beads and be carried by the air flow into the lungs of the patient.

Abstract: In accordance with the present invention, a method of electro-photographically manufacturing a luminescent screen assembly on an interior surface of a faceplate panel 12 for a color CRT 10 includes the steps of coating the interior surface of the faceplate panel with a volatilizable, organic conductive solution to form an organic conductive (OC) layer 32, and overcoating the OC layer with a volatilizable, organic photoconductive solution to form an organic photoconductive (OPC) layer 34. The step of overcoating the OC layer to form the OPC layer is improved by the substeps of: grounding the OC layer; providing an organic photoconductive (OPC) solution comprising a resin, an electron donor material and electron acceptor material, and a suitable solvent; and spraying electrostatically-charged droplets of the OPC solution onto the OC layer, with at least one electrostatic spray gun 47, to provide an OPC layer, having uniform thickness, overlying the OC layer.

Abstract: A method of manufacturing a luminescent screen assembly on an interior surface of a faceplate panel 12 for a color CRT 10 includes the steps of uniformly applying a solution of a material to form an organic conductive (OC) layer and overcoating the OC layer with a solution to form an organic photoconductive (OPC) layer, on the interior surface of the faceplate panel. The OPC layer 34 is conditioned by directing a stream of dry gas thereon to warm the OPC layer to a preheat temperature, while maintaining the panel at a panel temperature less than the preheat temperature. The OPC layer is exposed to IR radiation to rapidly increase the temperature of the OPC layer to a curing temperature, greater than the preheat temperature, to remove some of the volatilizable constituents from the OPC layer, without substantially increasing the temperature of the panel.

Abstract: In accordance with the present invention, an apparatus for developing a latent image formed on a photoreceptor, which is deposited on an interior surface of an output window of a display device, is disclosed. The developing apparatus includes a developing chamber, having a support surface for supporting the output window, a screen structure material reservoir for storing, deagglomerating and feeding the screen structure material, and a triboelectric gun assembly communicating with the reservoir. The gun assembly triboelectric charges and imparts a desired charge polarity to the screen structure material. The gun assembly further includes at least one material dispersing nozzle spaced from the support surface for distributing the charged material for deposition onto the latent image.

Abstract: In accordance with the present invention, a method of electrophotographically manufacturing a luminescent screen assembly for a color CRT 10 on an interior surface of a faceplate panel 12 is described. A volatilizable organic conductive (OC) layer 32 is provided on the interior surface of the panel and a volatilizable organic photoconductive (OPC) layer 34 overlies the OC layer 32.

Abstract: The method of electrophotographically manufacturing a screen assembly on an interior surface of a faceplate panel for a color CRT, according to the present invention includes the step of forming a photoreceptor by sequentially coating the surface of the panel with a conductive solution to form a volatilizable conductive layer and then overcoating the conductive layer with an organic photoconductive solution comprising a suitable resin, an electron donor material, an electron acceptor material, a surfactant and an organic solvent to form a volatilizable photoconductive layer.