Patents by Inventor Pablo GARCÍA DE LA RIVA MESTRE

Pablo GARCÍA DE LA RIVA MESTRE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell therapy with polarized macrophages for tissue regeneration
    Patent number: 10724004
    Abstract: The invention provides an in vitro method for inducing macrophage polarization to an M2 phenotype. The method comprises the in vitro exposure of macrophages to repeated series of hypoxia-reoxygenation. Activated M2 macrophages obtained by this method overexpress molecules important for tissue remodeling and amelioration of inflammation, thus they are useful as cell therapy for tissue regeneration. The invention also provides pharmaceutical compositions and kits comprising the M2 macrophages obtained by the method, as well as a device for inducing hypoxia and re-oxygenation conditions on isolated macrophages according to the method.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: July 28, 2020
    Assignee: XCELL MEDICAL SOLUTIONS, S.L.
    Inventors: María Georgina Hotter Corripio, Ana Maria Sola Martínez, Jorge Vicente Martín Cordero, Pablo García De La Riva Mestre, Rubén Domínguez Sánchez, Jaime Sánchez Moreno, Xavier Ginesta Buch, Anna Rodríguez García, Adrián Castillo García
  • CELL THERAPY WITH POLARIZED MACROPHAGES FOR TISSUE REGENERATION
    Publication number: 20180087031
    Abstract: The invention provides an in vitro method for inducing macrophage polarization to an M2 phenotype useful for tissue repair. The method described in the present invention comprises the in vitro exposure of macrophages to repeated series of hypoxia-reoxygenation. Activated M2 macrophages obtained by this method overexpress molecules important for tissue remodeling and amelioration of inflammation, such as NGAL and anti-inflammatory cytokines (IL-10). Thus, M2 macrophages obtained by this method are useful as cell therapy for tissue regeneration. The invention also provides pharmaceutical compositions and kits comprising the M2 macrophages obtained by the described method. The invention further refers to a device for inducing hypoxia and re-oxygenation conditions on isolated macrophages according to the described method.
    Type: Application
    Filed: September 25, 2017
    Publication date: March 29, 2018
    Inventors: María Georgina HOTTER CORRIPIO, Ana Maria SOLA MARTÍNEZ, Jorge Vicente MARTÍN CORDERO, Pablo GARCÍA DE LA RIVA MESTRE, Rubén DOMÍNGUEZ SÁNCHEZ, Jaime SÁNCHEZ MORENO, Xavier GINESTA BUCH, Anna RODRÌGUEZ GARCIA, Adrián CASTILLO GARCÍA