Abstract: Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using said compositions for inducing gene expression of mammalian genes.

Abstract: A tissue grasping device for use with an endoscope may include a sheath, a control wire slidably disposed within the sheath, and a helical coil disposed over and attached to the control wire. The helical coil may include a proximal region in which adjacent windings are in contact, and a distal region in which adjacent windings are spaced apart. The helical coil may have a sharpened distal tip.

Abstract: In some implementations, a receiver may obtain a digitized output of a radio frequency (RF) analog-to-digital-converter (ADC) of the receiver. The receiver may apply a spur cancellation to the digitized output of the RF ADC to attenuate one or more continuous wave spurs from the digitized output of the RF ADC, wherein the spur cancellation is based on a frequency planning with coherent averaging.

Abstract: The present disclosure provides for, among other things, methods and systems for detecting, diagnosing, predicting, monitoring, screening for, staging, and/or providing survival prognosis for advanced adenoma and/or colorectal cancer using DNA methylation markers. For example, described herein are DNA methylation markers that enable categorization and prognosis evaluation of advanced adenoma (AA) and/or colorectal cancer (CRC) patients with high accuracy from human biospecimens.

Abstract: A novel gRNA-ligand binding complex is provided. This complex may be used to bring Type V Cas proteins and additional effectors to DNA for base editing. The design of the systems allows for the production of efficient modular components that provide flexibility when editing DNA.

Abstract: The present disclosure provides prime editors, editor systems and methods of uses thereof. Specifically, the disclosure provides methods of use of split prime editors for editing genomic DNA.

Abstract: Method for variable arbitrary resampling that allows a base station test system to correct for sampling frequency errors relative to the base station. An output time calculation module obtains the required output sample times depending on the resampling rate, which can be tuned as needed. An input sample counter module counts the last input sample loaded into a polyphase interpolator, which can calculate any of M interpolated samples between two consecutive input samples. The polyphase interpolator uses the integer part of the required output sample times to decide what interpolated samples to calculate. A sequencer module compares the calculated output times against the input sample count to control all the blocks of the variable arbitrary resampler and determine if the output of the polyphase interpolator is a valid sample. Valid samples are transferred to other subsystems, such as a digital-to-analog data converter or another signal processing module.

Abstract: Methods, systems, and computer programs are presented for searching and labeling the content of voice conversations. An Engagement Intelligence Platform (EIP) analyzes conversation transcripts to find states and information for each of the states (e.g., interest rate quoted and value of the interest rate). An annotator User Interface (IU) is provided for performing queries, such as, “Find calls were the agent asked the customer for their name and the customer did not answer;” “Find calls where the customer objected after the interest rate for the loan was quoted, “Find calls where the agent asked for consent for recording the call, but no customer confirmation was received.” The EIP analyzes the conversation and labels (e.g., “tags”) the text where the conversation associated with the label took place, such as, “An interest rate was provided.” The labels are customizable, so each client can define its own labels based on business needs.

Abstract: Methods, systems, and computer programs are presented for searching and labeling the content of voice conversations. An Engagement Intelligence Platform (EIP) analyzes conversation transcripts to find states and information for each of the states (e.g., interest rate quoted and value of the interest rate). An annotator User Interface (IU) is provided for performing queries, such as, “Find calls were the agent asked the customer for their name and the customer did not answer;” “Find calls where the customer objected after the interest rate for the loan was quoted, “Find calls where the agent asked for consent for recording the call, but no customer confirmation was received.” The EIP analyzes the conversation and labels (e.g., “tags”) the text where the conversation associated with the label took place, such as, “An interest rate was provided.” The labels are customizable, so each client can define its own labels based on business needs.

Abstract: Systems and methods detect and prevent changes in business applications that modify its state to non-secure and/or non-compliant. A system may include a processor set up to perform: defining a compliant state of a computer software configuration, monitoring a state of the computer software configuration, detecting a change in the state of the computer software configuration, wherein the change causes a changed state, and comparing the compliant state and the changed state, wherein if the changed state conflicts with the compliant state, stopping the change.

Abstract: Security can be improved in a business application or system, such as a mission-critical application, by automatically analyzing and detecting anomalies for mission-critical applications. This detection may be based on a dynamic analysis of business process logs and audit trails that includes User and Entity Behavior Analysis (“UEBA”).

Abstract: A composite panel having a plurality of carbon plies, a perforated metallic foil comprising several apertures and being directly secured to the plurality of carbon plies, and a protective layer made from resin reinforced with fibers which is secured to the metallic foil. The perforated metallic foil is embedded in the protective layer through its apertures. A free surface of the protective layer forms a top side of the composite panel. The thickness of the protective layer between the top side of the composite panel and the perforated metallic foil is at least 15 micrometers and the perforated metallic foil has a thickness of not more than 30 micrometers. The plurality of apertures in the aggregate defines an open area of not more than 40% of the surface area and a maximum distance between two opposed points in a perimeter of an aperture is equal to or less than 3 mm.

Abstract: Systems and methods detect and prevent changes in business applications that modify its state to non-secure and/or non-compliant. A system may include a processor set up to perform: defining a compliant state of a computer software configuration, monitoring a state of the computer software configuration, detecting a change in the state of the computer software configuration, wherein the change causes a changed state, and comparing the compliant state and the changed state, wherein if the changed state conflicts with the compliant state, stopping the change.

Abstract: Systems and methods detect and prevent changes in business applications that modify its state to non-secure and/or non-compliant. A system may include a processor set up to perform: defining a compliant state of a computer software configuration, monitoring a state of the computer software configuration, detecting a change in the state of the computer software configuration, wherein the change causes a changed state, and comparing the compliant state and the changed state, wherein if the changed state conflicts with the compliant state, stopping the change.

Abstract: Methods, systems, and computer programs are presented for searching and labeling the content of voice conversations. An Engagement Intelligence Platform (EIP) analyzes conversation transcripts to find states and information for each of the states (e.g., interest rate quoted and value of the interest rate). An annotator User Interface (IU) is provided for performing queries, such as, “Find calls were the agent asked the customer for their name and the customer did not answer;” “Find calls where the customer objected after the interest rate for the loan was quoted, “Find calls where the agent asked for consent for recording the call, but no customer confirmation was received.” The EIP analyzes the conversation and labels (e.g., “tags”) the text where the conversation associated with the label took place, such as, “An interest rate was provided.” The labels are customizable, so each client can define its own labels based on business needs.

Abstract: The present invention relates to the detection of malicious software in electronic documents and comprises: detecting an executable code in the electronic document provided to a client module; extracting information from the electronic document comprising the executable code and metadata of the electronic document; creating a binary vector associated with the electronic document; comparing, in a classifier module (200), the binary vector with one or more groups of vectors previously classified and stored in a database (400); classifying the vector in one of the groups, where each group has associated therewith a verdict about the presence of malicious software; and determining that the document contains malicious software depending on the verdict associated with the group in which its associated vector has been classified.

Abstract: The disclosure provides a versatile method termed CRISPR-SKIP that utilizes cytidine and/or adenine deaminase base editors to program exon skipping by mutating target DNA bases within splice acceptor sites and/or splice enhancer sites.

Abstract: A business application, such as an enterprise resource planning (“ERP”) system, may include a number of different systems. Security management of the business application may include numerous systems and products. A combination of those systems and products into an underlying platform can include a single user interface that covers multiple security functions.

Abstract: A composite panel having a plurality of carbon plies, a perforated metallic foil comprising several apertures and being secured to the plurality of carbon plies, and a protective layer made from resin secured to the metallic foil. The perforated metallic foil is embedded in the protective layer through its apertures. A free surface of the protective layer forms a top side of the composite panel. The thickness of the protective layer between the top side of the composite panel and the perforated metallic foil is at least 15 micrometers and the perforated metallic foil has a thickness of not more than 30 micrometers.

Abstract: Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.