Patents by Inventor Pablo Perez-Pinera

Pablo Perez-Pinera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPLIT PRIME EDITING PLATFORMS
    Publication number: 20240026381
    Abstract: The present disclosure provides prime editors, editor systems and methods of uses thereof. Specifically, the disclosure provides methods of use of split prime editors for editing genomic DNA.
    Type: Application
    Filed: November 3, 2021
    Publication date: January 25, 2024
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Pablo Perez-Pinera, Wendy Woods, Jackson Winter, Michael Gapinske
  • METHODS FOR EXON SKIPPING AND GENE KNOCKOUT USING BASE EDITORS
    Publication number: 20210309986
    Abstract: The disclosure provides a versatile method termed CRISPR-SKIP that utilizes cytidine and/or adenine deaminase base editors to program exon skipping by mutating target DNA bases within splice acceptor sites and/or splice enhancer sites.
    Type: Application
    Filed: July 19, 2019
    Publication date: October 7, 2021
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Pablo PEREZ-PINERA, Michael P. GAPINSKE, Jackson Scott WINTER
  • RNA-GUIDED GENE EDITING AND GENE REGULATION
    Publication number: 20210032654
    Abstract: Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
    Type: Application
    Filed: July 13, 2020
    Publication date: February 4, 2021
    Inventors: Charles A. Gersbach, Isaac B. Hilton, Pablo Perez-Pinera, Ami M. Kabadi, Pratiksha I. Thakore, David G. Ousterout, Joshua B. Black
  • RNA-GUIDED GENE EDITING AND GENE REGULATION
    Publication number: 20210002665
    Abstract: Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
    Type: Application
    Filed: April 26, 2020
    Publication date: January 7, 2021
    Inventors: Charles A. Gersbach, Isaac B. Hilton, Pablo Perez-Pinera, Ami M. Kabadi, Pratiksha I. Thakore, David G. Ousterout, Joshua B. Black
  • RNA-guided gene editing and gene regulation
    Patent number: 10745714
    Abstract: Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: August 18, 2020
    Assignee: Duke University
    Inventors: Charles A. Gersbach, Isaac B. Hilton, Pablo Perez-Pinera, Ami M. Kabadi, Pratiksha I. Thakore, David G. Ousterout, Joshua B. Black
  • RNA-guided gene editing and gene regulation
    Patent number: 10704060
    Abstract: Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: July 7, 2020
    Assignee: Duke University
    Inventors: Charles A. Gersbach, Isaac B. Hilton, Pablo Perez-Pinera, Ami M. Kabadi, Pratiksha I. Thakore, David G. Ousterout, Joshua B. Black
  • RNA-GUIDED GENE EDITING AND GENE REGULATION
    Publication number: 20180320197
    Abstract: Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
    Type: Application
    Filed: May 29, 2018
    Publication date: November 8, 2018
    Inventors: Charles A. Gersbach, Isaac B. Hilton, Pablo Perez-Pinera, Ami M. Kabadi, Pratiksha I. Thakore, David G. Ousterout, Joshua B. Black
  • Vectors For Integration Of DNA Into Genomes And Methods For Altering Gene Expression And Interrogating Gene Function
    Publication number: 20180305719
    Abstract: The present disclosure provides vectors and methods for rapid and efficient integration of DNA at target sites in genomes with high efficiency. The present disclosure also provides methods for creating cell lines to model human diseases, for activating gene expression to correct genetic diseases or even for performing genetic screenings.
    Type: Application
    Filed: April 19, 2018
    Publication date: October 25, 2018
    Inventors: Pablo Perez-Pinera, Alexander Brown, Wendy S. Woods
  • COMPOSITIONS AND METHODS FOR THE INDUCTION AND TUNING OF GENE EXPRESSION
    Publication number: 20180094238
    Abstract: Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using said compositions for inducing gene expression of mammalian genes.
    Type: Application
    Filed: October 20, 2017
    Publication date: April 5, 2018
    Inventors: Pablo Perez-Pinera, Charles A. Gersbach
  • Compositions and methods for the induction and tuning of gene expression
    Patent number: 9828582
    Abstract: Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using said compositions for inducing gene expression of mammalian genes.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: November 28, 2017
    Assignee: Duke University
    Inventors: Pablo Perez-Pinera, Charles Gersbach
  • RNA-GUIDED GENE EDITING AND GENE REGULATION
    Publication number: 20160201089
    Abstract: Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
    Type: Application
    Filed: June 5, 2014
    Publication date: July 14, 2016
    Inventors: Charles A. Gersbach, Isaac B. Hilton, Pablo Perez-Pinera, Ami M. Kabadi, Pratiksha I. Thakore, David G. Ousterout, Joshua B. Black
  • COMPOSITIONS AND METHODS FOR THE INDUCTION AND TUNING OF GENE EXPRESSION
    Publication number: 20140309177
    Abstract: Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using said compositions for inducing gene expression of mammalian genes.
    Type: Application
    Filed: March 19, 2014
    Publication date: October 16, 2014
    Applicant: Duke University
    Inventors: Pablo Perez-Pinera, Charles Gersbach